Long-Term Health-Related Quality of Life, Growth, and Spiritual Well-Being After Hematopoietic Stem-Cell Transplantation

Andrykowski, Michael A.; Bishop, Michelle; Hahn, Elizabeth A.; Cella, David; Beaumont, Jennifer L.; Brady, Marianne J.; Horowitz, Mary M.; Sobocinski, Kathleen A.; Rizzo, J. Douglas; Wingard, John R.

doi:10.1200/jco.2005.03.189

Cited by 287 publications

(283 citation statements)

References 61 publications

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“…Relative to healthy controls, HSCT survivors reported poorer physical, psychological and social functioning that persists many years after HSCT. 111 Moreover, allo-HSCT patients are exposed to late complications, including infections, chronic GvHD, second cancers, iron overload and liver, endocrine, ocular, musculoskeletal, vascular, renal and neurologic disorders responsible for substantial morbidity. 112 The psychosocial aspect and quality of life is a major issue for these patients, with depression, anxiety, fatigue and sexual dysfunction being 34 Platelet count 35,37 Bilirubin level 13,24 Urea or creatinine level 24,37,38 Time between HSCT and ICU admission 13 Bacterial infections 25 ICU admission for neurological dysfunction 34 Abbreviations: APACHE II = Acute Physiology And Chronic Health Evaluation II; HCT-CI = hematopoietic cell transplantation comorbidity index; HSCT = hematopoietic stem cell transplantation; ICU = intensive care unit; MAC = myeloablative conditioning; MV = mechanical ventilation; RIC = reduced-intensity conditioning; RRT = renal replacement therapy; SAPS II = Simplified Acute Physiology Score II; SOFA = Sepsis Related Organ Failure Assessment.…”

Section: Limitations Of the Published Experiences And Unresolved Issuesmentioning

confidence: 99%

Critically ill allogeneic hematopoietic stem cell transplantation patients in the intensive care unit: reappraisal of actual prognosis

Saillard

Blaise

Mokart

2016

Bone Marrow Transplant

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The outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients has significantly improved over the past decade. Still, a significant number of patients require intensive care unit (ICU) management because of life-threatening complications. Literature from the 1990s reported extremely poor prognosis for critically ill allo-HSCT patients requiring ICU management. Recent data justify the use of ICU resources in hematologic patients. Yet, allo-HSCT remains an independent variable associated with mortality. However, outcomes in allo-HSCT patients have improved over time and many classic determinants of mortality have become irrelevant. The main actual prognostic factors are the need for mechanical ventilation, the presence of GvHD and the number of organ failures at ICU admission. Recently, the development of reduced-intensity conditioning regimens, early ICU admission and the increased use of noninvasive ventilation, combined with time effect and general advances in hematology, in allo-HSCT procedures and in ICU management have contributed to improve general outcome. A rational policy of ICU admission triage in these patients is very hard to define, as each decision for ICU admission is a case-by-case decision at patient bedside. The collaboration between hematologists and intensivists is crucial in this context.

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Section: Limitations Of the Published Experiences And Unresolved Issuesmentioning

confidence: 99%

Critically ill allogeneic hematopoietic stem cell transplantation patients in the intensive care unit: reappraisal of actual prognosis

Saillard

Blaise

Mokart

2016

Bone Marrow Transplant

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“…Most HRQoL research in SCT patients has been conducted with adults. In the majority of the studies, a negative impact on the HRQoL evaluation in a proportion of adults has been found [9,11,40], often due to functional limitations and somatic symptoms [9] and to concerns about relapsing [2,4].…”

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confidence: 99%

“…The current study was designed to assess the (1) selfand proxy-reported HRQoL compared to a norm group, (2) levels of parenting stress compared to a norm group, (3) differences in HRQoL and parenting stress pre-and post-SCT, and (4) effect of child age and parenting stress on selfand proxy-reported HRQOL pre-and post-SCT.…”

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confidence: 99%

Child and parental adaptation to pediatric stem cell transplantation

Vrijmoet-Wiersma

Kolk

Grootenhuis

et al. 2008

Support Care Cancer

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Goals of work Allogeneic pediatric stem cell transplantation (SCT) is a very intensive treatment with a high mortality and morbidity. The objectives of this study were to assess the (1) self-and proxy-reported health-related quality of life (HRQoL) compared to a norm group, (2) levels of parenting stress compared to a norm group, (3) differences in HRQoL and parenting stress pre-and post-SCT, and (4) effect of child age and parenting stress on selfand proxy-reported HRQoL pre-and post-SCT. Materials and methods Pre-and on average 10 months post-SCT, 21 children and adolescents and their parent(s) completed questionnaires on HRQoL and the mothers completed a measure of parenting stress. Main results Post-SCT, home functioning, physical functioning, and total HRQoL scores were lower than the norm group. We found stable HRQoL scores over time with the exception of the domain home functioning, which was rated lower post-SCT than pre-SCT. Parents reported lower HRQoL scores than the children pre-and post-SCT and younger children experienced better HRQoL than older children. Parenting stress was higher post-SCT than pre-SCT and high levels of parenting stress were predictive of poor parental ratings of child HRQoL post-SCT. Conclusions Ongoing psychosocial assessment post-SCT is necessary to target children with a lowered HRQoL and parents who experience elevated parenting stress who may be in greater need of more supportive care.

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“…The studies note that the proportion of patients with good sleep varies about 55-80%, but that observed sleep difficulties are significantly worse compared with a healthy comparison group. [12][13][14] Andrykowski et al 15 analyzed the sleep quality of patients who received BMT 12-124 months ago. They found that approximately half of the participants had mild sleep difficulties.…”

Section: Introductionmentioning

confidence: 99%

Sleep disturbances and emotional distress in the acute course of hematopoietic stem cell transplantation

Rischer

Scherwath

Zander

et al. 2009

Bone Marrow Transplant

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Recent research has shown that patients undergoing hematopoietic SCT (HSCT) experience multiple symptoms that can affect the sleep quality adversely. This study investigated the sleep quality of patient in the acute course of HSCT, and measured the impact of sociodemographic, medical, physical and psychological factors. Fifty patients were assessed before admission, 44 participated during inpatient treatment and 32 on day 100 ( ± 20) posttransplantation. Measuring instruments included the Pittsburgh Sleep Quality Index (PSQI) and a sleep diary (sleep quality), the European Organization for Research and Treatment of Cancer Quality of Life QuestionnaireCore 30 (health-related quality of life), the Hospital Anxiety and Depression Scale -German version (anxiety/depression) and the German version of the Cancer and Treatment Distress Scale (treatment-specific distress). The prevalence of sleep disturbances was 32% before admission, 77% during the hospital stay and 28% after discharge. Difficulty in maintaining sleep was the most intense sleep problem during the inpatient phase. This was mainly caused by disturbing noises and need to use the bathroom frequently. Sleep problems were significantly worse during the hospital stay compared with the other measurement points in time (Po0.001). A significant interaction was seen between the time course of sleep disturbances and the type of transplantation (P ¼ 0.001). The findings suggest that sleep disturbances after HSCT are particularly associated with physical functioning, fatigue and treatment-specific distress, and factors that contribute to sleep difficulties in the general population seem to be less important.

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Long-Term Health-Related Quality of Life, Growth, and Spiritual Well-Being After Hematopoietic Stem-Cell Transplantation

Cited by 287 publications

References 61 publications

Critically ill allogeneic hematopoietic stem cell transplantation patients in the intensive care unit: reappraisal of actual prognosis

Critically ill allogeneic hematopoietic stem cell transplantation patients in the intensive care unit: reappraisal of actual prognosis

Child and parental adaptation to pediatric stem cell transplantation

Sleep disturbances and emotional distress in the acute course of hematopoietic stem cell transplantation

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