Long-term growth hormone treatment in growth hormone deficient adults

Jørgensen, Jens O. L.; Pedersen, Søren Anker; Thuesen, Leif; Jørgensen, Jørgen; Møller, Jens Kjølseth; Müller, Jørn; Skakkebæk, Niels E.; Christiansen, Jens Sandahl

doi:10.1530/acta.0.1250449

Cited by 142 publications

(81 citation statements)

References 17 publications

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“…These hormones are indispensable for life. Currently, other hormonal replacement therapy, such as for sex steroids or GH [25,26], still under clinical research, can be tried. These hormones are not indispensable for life, but their appropriate administration may improve the quality of life.…”

Section: Discussionmentioning

confidence: 99%

Anterior Pituitary Function in Patients with Nonfunctioning Pituitary Adenoma: Results of Longitudinal Follow-up.

et al. 1995

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Abstract.Studies of anterior pituitary function in patients treated for nonfunctioning pituitary adenomas have been limited by their short duration. The purpose of the present study was to examine pituitary function longitudinally among three types of patients: those with complete tumor removal (group A); those with subtotal or partial adenomectomy (group B); and those in group B who underwent additional radiation therapy (group C). The subjects were 33 patients whose anterior pituitary function was evaluated by provocative tests such as insulin induced hypoglycemia, thyrotropin releasing hormone administration test and luteinizing hormone releasing hormone administration test. They underwent preoperative evaluation and postoperative reevaluations at 2 weeks, 3 months, 6 months and annually thereafter, for over 10 years. Anterior pituitary function was restored within a year after surgery, if at all. No additional function was restored after one year from treatment. In group A, no one developed impairment of anterior pituitary function after one year from surgery. In group B, however, new impairment was noted at intervals, due to tumor regrowth. In Group C, deficiencies developed after one year, irrespective of tumor regrowth. In conclusion, lifelong endocrinological follow-up is recommended for patients receiving postoperative irradiation, and for patients with potential for tumor regrowth.On the other hand, patients with total adenomectomy may be exempted from periodic endocrinological follow-up if they do not need postoperative hormonal replacement therapy.

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Section: Discussionmentioning

confidence: 99%

Anterior Pituitary Function in Patients with Nonfunctioning Pituitary Adenoma: Results of Longitudinal Follow-up.

et al. 1995

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“…Although the existence of GH deficiency syndrome in normal elderly subjects is still not generally recognized, several investigators have initiated GH treatment for elderly patients with relative hyposomatotropinemia, with improvements observed in all these conditions (4). GH administration to non-elderly adults and older persons increases lean body mass and reduces fat mass substantially, increases basal metabolic rate, nitrogen and phosphate retention, spinal bone density, and significantly decreases fasting cholesterol levels (4,6,7).…”

Section: Introductionmentioning

confidence: 99%

Sensitivity to exogenous GH and reversibility of the reduced IGF-I gene expression in aging rats

Velasco

Cacicedo

Melián

et al. 2001

European Journal of Endocrinology

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Background: IGF-I gene expression and IGF-I plasma concentration decline with age. A decreased sensitivity to GH has been suggested to be a contributory mechanism to this, in addition to attenuated GH secretion. Objective: This study focuses on the sensitivity to exogenous GH and the reversibility of the reduced IGF-I gene expression in aging male rats. Design: Three groups of male Wistar rats aged 3 months (young adult), 11 months (middle-aged) and 27 months (old), received recombinant human GH (rhGH) (150 mg/12 h s.c.) for seven consecutive days.Results: This rhGH treatment completely reversed plasma immunoreactive IGF-I (IR-IGF-I) and hepatic IGF-I mRNA levels in 11-month-old and 27-month-old animals to the levels of the young group of animals. The sensitivity in the old group (percentage of increment after the same or lower dose of rhGH per body weight) was increased for both parameters; serum IGF-I increment: 15% in 3-month-old, 42.6% in 11-month-old and 119.1% in 27-month-old rats; and hepatic IGF-Ib mRNA increase: 45% in 3-month-old, 27.8% in 11-month-old and 64.3% in 27-month-old rats. IGF binding protein-3 (IGFBP-3) mRNA level in the liver was significantly decreased in the old group and only a partial reversion occurred in this group after rhGH treatment; the percentage of increment was also higher in the old group of rats. In extrahepatic tissues IGF-I mRNA was not significantly different in the kidney and the testis of the three groups, and the rhGH treatment produced a significant and similar increase of IGF-I mRNA level in the kidney of the three groups of rats and in the testis of the 27-month-old animals. The GHr/GHBP mRNA remained unchanged in the liver and in the kidney or the testis of the three groups, and was not influenced by the rhGH treatment. Exogenous rhGH decreased pituitary GH mRNA accumulation in a more intense manner in the old group versus control of each group: young adult, 25%; middle-aged, 41.2%; and old rats, 55%. The action of rhGH on pituitary immunoreactive GH (IR-GH) content was only significantly evident in the young group. Conclusions: These results establish that exogenous rhGH recovers the attenuated liver IGF-I gene expression and the diminished plasma IR-IGF-I in old rats to the levels of young adult animals. They also indicate that the hepatic and extrahepatic (kidney and testis) sensitivity to one established dose per weight of exogenous rhGH is not altered in old animals, or could be potentially increased in some tissues.

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“…GH-deficient patients display improvement in their exercise capacity (17,32) and maximum oxygen uptake (17) Interestingly, a decrease in total body bone mineral density was seen after both 6 and 12 months. Thus it seems that rhGH treatment during the initial phase increases bone resorption, causing an expansion of the "remodelling space" (51).…”

Section: Effects On Cardiac and Pulmonary Functionmentioning

confidence: 99%

Consequences of Growth Hormone Deficiency (GHD) in Adults and the Effects of Replacement Therapy with Recombinant Human Growth Hormone (rhGH)

Bengtsson

Rosén

Johannsson

et al. 1994

Clin Pediatr Endocrinol

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Long-term growth hormone treatment in growth hormone deficient adults

Abstract: Growth hormone treatment in GH-deficient adults has proved beneficial in recent short-term trials, but long-term results have not yet been reported. Thirteen GH-deficient adults (4 females, 9 males; mean (sem)

Cited by 142 publications

References 17 publications

Anterior Pituitary Function in Patients with Nonfunctioning Pituitary Adenoma: Results of Longitudinal Follow-up.

Anterior Pituitary Function in Patients with Nonfunctioning Pituitary Adenoma: Results of Longitudinal Follow-up.

Sensitivity to exogenous GH and reversibility of the reduced IGF-I gene expression in aging rats

Consequences of Growth Hormone Deficiency (GHD) in Adults and the Effects of Replacement Therapy with Recombinant Human Growth Hormone (rhGH)

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