Long-Term Follow-Up on Health-Related Quality of Life After Mechanical Circulatory Support in Children

Abstract

Long-term survivors' health-related quality of life as reported by their parents is lower than that of healthy children. However, the self-assessed health-related quality of life of the patients older than 12 years in our group is comparable to a healthy control population.

Neonatal respiratory and cardiac ECMO in Europe

“…There are considerable data regarding survival to hospital discharge of neonates receiving ECMO for cardiac failure; however, limited data exist on intermediate-and long-term outcomes. Among survivors, 40-60% reported new neurologic deficits and low health-related quality of life than healthy controls [188][189][190]. Neurologic complications may have variable features (language acquisition delay, motor development stages delay, behavioral problems) and represent a source of significant morbidity and long-term care requirements [190].…”

“…Among survivors, 40-60% reported new neurologic deficits and low health-related quality of life than healthy controls [188][189][190]. Neurologic complications may have variable features (language acquisition delay, motor development stages delay, behavioral problems) and represent a source of significant morbidity and long-term care requirements [190]. Due to the cohorts' heterogeneity, which includes different age groups and different ECMO indications (ECPR, low cardiac output syndrome, septic shock, myocarditis), a robust conclusion cannot be achieved.…”

Psychosocial outcomes in pediatric patients with ventricular assist devices and their families: A systematic review

“…The majority of studies established inclusion criteria and consistent selection procedures (n = 12; 75%), [20][21][22][23][24][25][26][27][28][29][30][31] defined the study population, including time period and geographical location of recruitment (n = 11; 69%), 20,21,[23][24][25][26][27][28][29][30][31] and utilized defined outcomes with validated measures (n = 11; 69%). 20,21,23,24,26,27,29,[31][32][33][34] Ten studies (63%) reported a participation rate of greater than 50%, [20][21][22][23][24][25][26][27]29,31 though the remaining six studies did not report participation or attrition results. Notably, few studies justified sample size or utilized effect sizes (n = 4; 25%), 21,29,30,…”

“…Notably, few studies justified sample size or utilized effect sizes (n = 4; 25%), 21,29,30,35 and few statistically considered potential confounding variables in analyses (n = 4; 25%), 21,23,26,29 though six studies utilized qualitative data and thematic analyses, and thus statistical assessment of confounding variables was rated NA. 22,25,28,30,33,35 Based on the results of this quality assessment, 50% of included studies were rated as "good" quality (n = 8) 20,21,23,24,26,27,29,31 and 50% of included studies were rated as "fair" quality (n = 8). 22,25,28,30,[32][33][34][35] No studies were excluded from the current literature reviewed based on the quality assessment.…”

Improvement in patient-reported outcomes after lung transplantation is not impacted by the use of extracorporeal membrane oxygenation as a bridge to transplantation

“…For example, survivors of general critical illness have poorer physical functioning than healthy controls and have a high incidence of depressive symptoms 19,20 . Furthermore, those who survived critical illness with the assistance of ECMO report poor subsequent HRQL and persistent physical and emotional health limitations 21–23 . Since surviving to lung transplant through ECMO might be similar to surviving critical illness, it is plausible that the impact of lung transplant on HRQL benefit could be attenuated in this group.…”