Long-term exposure to outdoor light at night and mild cognitive impairment: A nationwide study in Chinese veterans

Chen, Yan; Tan, Jiping; Liu, Yuewei; Dong, Guang‐Hui; Yang, Bo‐Yi; Li, Nan; Wang, Luning; Chen, Gongbo; Li, Shanshan; Lee, Hyewon

doi:10.1016/j.scitotenv.2022.157441

Cited by 14 publications

(10 citation statements)

References 40 publications

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“…Amish communities have a lower prevalence of cognitive impairment in individuals of advanced age compared to the general population (Johnson et al 1997; Holder and Warren 1998; Pericak-Vance et al 1996). Numerous factors other than light exposure may contribute to this phenomenon (e.g., emphasis on family / community, traditional farming, genetics), but that being said, exposure of Drosophila to dim light during the dark period promotes neurodegeneration (Kim et al 2018), and data from mice demonstrate that dim light during the dark period alters neuronal dendrites in AD-relevant brain regions (cortex, hippocampus) (Delorme et al 2022), and long-term exposure to outdoor light at night is associated with increased risk of cognitive impairment in humans (Chen et al 2022), and there is a positive correlation between light pollution and Parkinson’s disease (another neurodegenerative disease) (Romeo et al 2013). Additional studies carefully evaluating indoor and outdoor light exposure and mechanistic evaluations are needed to fully understand the impact of nighttime light exposure and light pollution on AD.…”

Section: Discussionmentioning

confidence: 99%

“…Incidence and prevalence of AD have increased in recent decades which parallels the increase in light pollution. Evidence suggests that exposure to light at night may promote neurodegeneration, neuroinflammation, dementia, and AD (Kim et al 2018; Delorme et al 2022; Walker et al 2020; Chen et al 2022; Mazzoleni et al 2023; Romeo et al 2013), but this possibility has not been carefully examined.…”

Section: Introductionmentioning

confidence: 99%

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Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer’s Disease

Voigt,

Ouyang,

Keshavarzian

2024

Preprint

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Alzheimer disease (AD) prevalence has increased in the last century which can be attributed to increased lifespan, but environment is also important. This study evaluated the relationship between outdoor nighttime light exposure and AD prevalence in the United States. Higher outdoor nighttime light was associated with higher prevalence of AD. While atrial fibrillation, diabetes, hyperlipidemia, hypertension, and stroke were associated more strongly with AD prevalence than nighttime light intensity, nighttime light was more strongly associated with AD prevalence than alcohol abuse, chronic kidney disease, depression, heart failure, and obesity. Startlingly, nighttime light exposure more strongly associated with AD prevalence in those under the age of 65 than any other disease factor examined. These data indicate a need to investigate how nighttime light exposure influences AD pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer’s Disease

Voigt,

Ouyang,

Keshavarzian

2024

Preprint

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“…First, this was an observational study, and although multiple potential confounding factors were adjusted, causality could not be inferred. Second, although the use of satellite night-time light data as a surrogate indicator for nocturnal light exposure was a common practice in many previous epidemiological studies, [26][27][28][29] this approach does indeed have limitations. Factors such as household curtains, residential location (proximity to streets, orientation, floor level, etc.…”

Section: Quartiles Of Lanmentioning

confidence: 99%

Association between outdoor light at night and hypertension and high‐normal blood pressure: A nationwide cross‐sectional study among Chinese adults

Wang,

Hu,

et al. 2024

J of Clinical Hypertension

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The authors aimed to investigate the association between outdoor light at night (LAN) intensity and blood pressure. The study included 13 507 participants aged 45 and above from the 2011–2012 China Health and Retirement Longitudinal Study baseline survey. Blood pressure measurements were obtained by averaging the last two readings recorded (three measurements with an interval of 45–60 s between each measurement) during the survey. Outdoor LAN intensity was assessed using Defense Meteorological Satellite Program data. The study categorized participants based on quartiles of outdoor LAN intensity and employed statistical methods like linear regression, restricted cubic splines, and logistic models to analyze the connections. After adjusting for potential confounding factors, higher levels of outdoor LAN intensity were associated with increase in systolic blood pressure (0.592 mmHg/interquartile range [IQR], 95% confidence interval [CI]: 0.027,1.157), diastolic blood pressure (0.853 mmHg/IQR, 95% CI: 0.525,1.180) and mean arterial pressure (0.766 mmHg/IQR, 95% CI: 0.385,1.147). Interestingly, the relationship between LAN intensity and odds of hypertension followed a non‐linear pattern, resembling a reverse “L” shape on cubic splines. Participants with the highest quartile of outdoor LAN intensity had 1.31‐fold increased odds of hypertension (95% CI: 1.08–1.58) compared to the lowest quartile. Additionally, there was an observable trend of rising odds for high‐normal blood pressure with higher levels of LAN intensity in the crude model, but no statistically significant differences were observed after adjusting for confounding factors. In conclusion, this study underscores a significant connection between outdoor LAN intensity and the prevalence of hypertension.

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“…The latter shows the possible association with triggering neurodegeneration since sleep is essential for neurons to regenerate their plasticity and remove toxic compounds. In light pollution and its impact on neurodegeneration, the role of outdoor and indoor dim artificial light at night (dLAN) is noted [ 7 , 8 ]. The dLAN strength is usually 5–10 lux which is also said to be the minimum quantity of light pollution in many countries [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The dLAN strength is usually 5–10 lux which is also said to be the minimum quantity of light pollution in many countries [ 9 ]. It is discussed whether Alzheimer’s disease (AD) as a neurodegenerative disease may be induced by inappropriate artificial light [ 7 , 8 ]. AD is one of the most common types of dementia and neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%

Artificial light and neurodegeneration: does light pollution impact the development of Alzheimer’s disease?

Karska,

Kowalski,

Gładka

et al. 2023

GeroScience

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Two multidimensional problems of recent times — Alzheimer’s disease and light pollution — seem to be more interrelated than previously expected. A series of studies in years explore the pathogenesis and the course of Alzheimer’s disease, yet the mechanisms underlying this pathology remain not fully discovered and understood. Artificial lights which accompany civilization on a daily basis appear to have more detrimental effects on both environment and human health than previously anticipated. Circadian rhythm is affected by inappropriate lighting conditions in particular. The consequences are dysregulation of the sleep-wake cycle, gene expression, neuronal restructuring, brain’s electricity, blood flow, metabolites’ turnover, and gut microbiota as well. All these phenomena may contribute to neurodegeneration and consequently Alzheimer’s disease. There is an increasing number of research underlining the complexity of the correlation between light pollution and Alzheimer’s disease; however, additional studies to enhance the key tenets are required for a better understanding of this relationship.

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Long-term exposure to outdoor light at night and mild cognitive impairment: A nationwide study in Chinese veterans

Cited by 14 publications

References 40 publications

Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer’s Disease

Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer’s Disease

Association between outdoor light at night and hypertension and high‐normal blood pressure: A nationwide cross‐sectional study among Chinese adults

Artificial light and neurodegeneration: does light pollution impact the development of Alzheimer’s disease?

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