volume 6, issue 5, P369-379 2014
DOI: 10.18632/aging.100663
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Yuyani Xiong, Michael Forbiteh Fru, Yi Yu, Jean-Pierre Montani, Xiu-Fen Ming, Zhihong Yang

Abstract: L-arginine supplementation is proposed to improve health status or as adjunct therapy for diseases including cardiovascular diseases. However, controversial results and even detrimental effects of L-arginine supplementation are reported. We investigate potential mechanisms of L-arginine-induced detrimental effects on vascular endothelial cells. Human endothelial cells were exposed to a physiological (0.1 mmol/L) or pharmacological (0.5 mmol/L) concentration of L-arginine for 30 minutes (acute) or 7 days (chron…

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