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“…Most of the balneotherapeutic studies abroad have never used a placebo control (15,16,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37), despite the fact that this would be one of the most important steps in proving the beneficial effects of medicinal waters. In Hungarian studies, it is more common to use a placebo control (4,7,(38)(39)(40).…”
Section: Discussionmentioning
confidence: 99%
“…Most of the balneotherapeutic studies abroad have never used a placebo control (15,16,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37), despite the fact that this would be one of the most important steps in proving the beneficial effects of medicinal waters. In Hungarian studies, it is more common to use a placebo control (4,7,(38)(39)(40).…”
Section: Discussionmentioning
confidence: 99%
“…(11). The randomized controlled crossover study performed by the same study group showed the beneficial effects of spa therapy applied to patients with rheumatoid arthritis in addition to pharmacotherapy (19). Studies on AS have shown that mud treatments and thermal baths are useful in AS and other spondyloarthritis (11,17,(21)(22)(23)(24).…”
Section: Discussionmentioning
confidence: 99%
“…Balneotherapy traditionally refers to using thermal mineral waters (also mud/peloid) in different combinations (Fioravanti et al 2017;Karagülle et al 2018). This therapy method is a clinically effective complementary approach in the treatment of stress-related pathologies, because it is leading to antiinflammatory, analgesic, antioxidant, chondroprotective and anabolic effects together with neuroendocrineimmune regulation (Kerdes et al 2017;Galvez et al, 2018).…”
Section: Introductionmentioning
confidence: 99%