Long-term Effects of Nasal Continuous Positive Airway Pressure Therapy on Cardiovascular Outcomes in Sleep Apnea Syndrome

Doherty, Liam S.; Kiely, John; Swan, Valerie; McNicholas, Walter T.

doi:10.1378/chest.127.6.2076

Cited by 432 publications

(301 citation statements)

References 37 publications

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“…2 A growing body of literature suggests that OSA has been implicated in the development of cardiorespiratory diseases. [3][4][5][6][7][8][9][10] OSA also has a significant impact on both acute and chronic cardiorespiratory function. 11 Although no large epidemiologic studies have been undertaken to determine the prevalence of OSA in the general surgical population, reports of several studies suggest that the prevalence of OSA in the surgical population might be higher than in the general population, with variability among different surgical populations.…”

Section: Résumémentioning

confidence: 99%

Postoperative complications in patients with obstructive sleep apnea: a retrospective matched cohort study

Liao

Yegneswaran

Vairavanathan

et al. 2009

Can J Anesth/J Can Anesth

276

149

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Purpose Obstructive sleep apnea (OSA) is presumed to be a risk factor for postoperative morbidity and mortality, but the current evidence is incomplete. This retrospective matched cohort study tested the hypothesis that OSA is a risk factor for the development of postoperative complications. Methods Hospital ethics approval was obtained for the conduct of this study. The patients who were selected for the study were [18 yr of age, diagnosed preoperatively with OSA, and scheduled to undergo elective surgery. A cohort of surgical patients without OSA was used as a comparator group based on a one-to-one match. Matching criteria included gender, age difference \5 yr, type of surgery, and a \5 yr difference between two surgery dates. Summary data are presented and conditional logistic regression was used to identify risk factors for postoperative complications.Results The 240 pairs of study subjects aged 57 ± 13 yr included 184 (77%) males and 56 (23%) females. The OSA patients had a higher mean body mass index relative to their non-OSA counterparts (35 ± 9 vs 28 ± 6 kg Á m -2 , respectively) and a higher frequency of co-morbidities, including hypertension (48% vs 36%, respectively) and obesity (61% vs 23%, respectively). Also, the incidence of postoperative complications in the OSA patients was significantly greater (44% OSA group vs 28% non-OSA

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Section: Résumémentioning

confidence: 99%

Postoperative complications in patients with obstructive sleep apnea: a retrospective matched cohort study

Liao

Yegneswaran

Vairavanathan

et al. 2009

Can J Anesth/J Can Anesth

276

149

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“…However, although OSAS is relatively prevalent in middleaged adults ( Young et al 1993) and pre-school children (Gislason & Benediktsdottir 1995), only 10-15 per cent have been diagnosed (Young et al 1997). Diagnosis and treatment are important as effective therapy leads to significant reductions in cardiovascular mortality and non-fatal cardiovascular events (Doherty et al 2005;Marin et al 2005). The standard for OSAS diagnosis is overnight attended polysomnography (PSG; Kushida et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Multimodal detection of sleep apnoea using electrocardiogram and oximetry signals

Chazal

Heneghan

McNicholas

2008

Phil. Trans. R. Soc. A.

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A method for the detection of sleep apnoea, suitable for use in the home environment, is presented. The method automatically analyses night-time electrocardiogram (ECG) and oximetry recordings and identifies periods of normal and sleep-disordered breathing (SDB). The SDB is classified into one of six classes: obstructive, mixed and central apnoeas, and obstructive, mixed and central hypopnoeas. It also provides an estimated apnoea, hypopnoea and apnoea-hypopnoea index. The basis of the method is a pattern recognition system that identifies episodes of apnoea by analysing the heart variability, an ECG-derived respiration signal and blood oximetry values. The method has been tested on 183 subjects with a range of apnoea severities who have undergone a full overnight polysomnogram study. The results show that the method separates control subjects from subjects with clinically significant sleep apnoea with a specificity of 83 per cent and sensitivity of 95 per cent. These results demonstrate that home-based screening for sleep apnoea is a viable alternative to hospital-based tests with the added benefit of low cost and minimal waiting times.

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“…118 Another observational cohort study examined the impact of CPAP on long-term cardiovascular outcomes in patients with sleep apnea and showed that CPAP therapy reduces fatal and nonfatal cardiovascular events and protected against death from cardiovascular disease. 44,119,120 Short-term randomized trials have been studying systemic blood pressure as the outcome. Although the results have been different with respect to the magnitude of blood pressure reduction, it seems to be a clinically important blood pressure reduction.…”

Section: Early Treatment Of Obstructive Sleep Apnea In Cardiovascularmentioning

confidence: 99%

Rehabilitation of Cardiovascular Disorders and Sleep Apnea

Jafari

2017

Sleep Medicine Clinics

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Long-term Effects of Nasal Continuous Positive Airway Pressure Therapy on Cardiovascular Outcomes in Sleep Apnea Syndrome

Cited by 432 publications

References 37 publications

Postoperative complications in patients with obstructive sleep apnea: a retrospective matched cohort study

Postoperative complications in patients with obstructive sleep apnea: a retrospective matched cohort study

Multimodal detection of sleep apnoea using electrocardiogram and oximetry signals

Rehabilitation of Cardiovascular Disorders and Sleep Apnea

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