2010
DOI: 10.1002/jbm.b.31649
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Abstract: Objectives To characterize the interaction of 1-Ethyl-3-[3-dimethylaminopropyl] carbodiimide Hydrochloride (EDC) with dentin matrix and its effect on the resin-dentin bond. Methods Changes to the stiffness of demineralized dentin fragments treated with EDC/N-hydroxysuccinimide (NHS) in different solutions were evaluated at different time points. The resistance against enzymatic degradation was indirectly evaluated by ultimate tensile strength (UTS) test of demineralized dentin treated or not with EDC/NHS and… Show more

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Cited by 87 publications
(145 citation statements)
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“…196 Carbodiimide hydrochloride (EDC) has also been proposed as an effective collagen cross-linker as it has been shown to improve the durability and structural integrity of the adhesive interface, thus preserving its bond strength over time, and this through the formation of inter-and intra-molecular cross-links. 199,200,201,202 Moreover, EDC is one of the least cytotoxic and most stable cross linkers. 58 EDC also seems to be capable of inactivating dentinal gelatinases.…”
Section: Cross-linkersmentioning
confidence: 99%
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“…196 Carbodiimide hydrochloride (EDC) has also been proposed as an effective collagen cross-linker as it has been shown to improve the durability and structural integrity of the adhesive interface, thus preserving its bond strength over time, and this through the formation of inter-and intra-molecular cross-links. 199,200,201,202 Moreover, EDC is one of the least cytotoxic and most stable cross linkers. 58 EDC also seems to be capable of inactivating dentinal gelatinases.…”
Section: Cross-linkersmentioning
confidence: 99%
“…58 EDC also seems to be capable of inactivating dentinal gelatinases. 200,201,202 It should be considered, however, that it is currently designed to be used just after acid-etching, in etch-and-rinse adhesives. 58 Genipin is a natural cross-linking agent that can react with the amino groups of lysine, hydroxylysine or arginine to form intra or inter-molecular cross-links within collagen molecule or between adjacent collagen molecules.…”
Section: Cross-linkersmentioning
confidence: 99%
“…The treatment of demineralized dentin with EDC (1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride) or glutaraldehyde (GA) increases the mechanical properties of dentin collagen 18 and inhibits MMPs 19,20 by creating new cross-links among protein peptide chains. EDC is capable of forming covalent peptide bonds between peptide chains by activating the free carboxyl group of glutamic and aspartic acids, 21,22 while GA reacts with the e-amino groups of lysyl or hydroxylysyl residues to induce the formation of intra-and intermolecular cross-links.…”
Section: Introductionmentioning
confidence: 99%
“…EDC is capable of forming covalent peptide bonds between peptide chains by activating the free carboxyl group of glutamic and aspartic acids, 21,22 while GA reacts with the e-amino groups of lysyl or hydroxylysyl residues to induce the formation of intra-and intermolecular cross-links. 23,24 Although the effects of EDC and GA have been demonstrated on collagen biomodification, 18,25 rendering collagen more resistant to degradation by improving its mechanical properties, such as elastic modulus and ultimate tensile strength, and MMP inhibiton, 19,20 there is little information available about their cytotoxicity. The carbodiimides have shown better results than has GA in terms of the biocompatibility on U937 macrophage-like cells, 26 rat ocular cells/tissue, 27 and corneal endothelial cells.…”
Section: Introductionmentioning
confidence: 99%
“…Oldukça düşük sitotoksisitesi vardır ve dentin kollajen yıkımının azalmasında umut vadeden sonuçları vardır. 43 Çapraz bağlanma özelliği ile dentine bağlanma stabilitesini arttırmaktadır. 44 Seseogullari-Dirihan ve ark.…”
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