Long-term dwarfing effects of corticosteroid treatment for childhood nephrosis.

Lam, CW; Arneil, Gavin C.

doi:10.1136/adc.43.231.589

Cited by 65 publications

(33 citation statements)

References 21 publications

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“…The glucocorticoid hormones inhibit epiphyseal cartilage growth and decrease the metabolic activity of cartilage cells (9,10). The somatomedins, on the other hand, are growth-promoting polypeptides which stimulate epiphyseal cartilage growth and increase the svnthesis of a number of functional and structural proteins (6).…”

Section: Speculationmentioning

confidence: 99%

Alteration of Cartilage Glycosaminoglycan Protein Acceptor by Somatomedin and Cortisol

et al. 1979

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SummaryThe effect of somatomedin and cortisol on embryonic chick cartilage in vitro indicates that somatomedin stimulates 35S01 uptake while cortisol decreases it with no effect on glycosaminoglycan turnover. Xylosyltransferase activity is increased in crude fractions of somatomedin-treated cartilage but decreased in cortisol-treated cartilage. By using a Smith-degraded proteoglycan as an exogenous acceptor, xylosyltransferase activities from both treatments were equivalent, suggesting that the enzyme was not rate limiting. The results of xylosyltransferase assays conducted by mixing enzyme and endogenous acceptor from control, cortisoltreated, and somatomedin-treated cartilage, suggest both effects to be at the level of the acceptor protein.

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Section: Speculationmentioning

confidence: 99%

Alteration of Cartilage Glycosaminoglycan Protein Acceptor by Somatomedin and Cortisol

et al. 1979

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“…Lam and Arneil noted that children treated with high dose steroids for up to 6 months did not appear to have significant effects on height 5 to 10 years later. However, when corticosteroid therapy was extended to 18 months, an ultimate loss in height percentiles was observed (3). On the other hand, in long-term studies where children were treated with intermittent courses of corticosteroids as well as alternate day regimens, no effect on ultimate height attainment was noted generally (4,5).…”

mentioning

confidence: 99%

“…Growth retardation is a significant problem in children receiving long-term corticosteroid treatment for frequent-relapsing nephrotic syndrome (1,2). This effect of corticosteroids on growth appears to depend on both dosage and on the duration of therapy.…”

mentioning

confidence: 99%

Can Growth Hormone Treatment Improve the Growth Retardation in Children Associated with Steroid Dependent Nephrotic Syndrome

Yap

Loke

Lee

1997

Clin Pediatr Endocrinol

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“…Growth retardation is a potential side effect of corticosteroids, especially in steroid-dependent children. The degree of growth retardation in children with nephrotic syndrome depends mainly on dosage, duration and type of steroid application [4][5][6]. Only a few studies have analyzed the long-term outcome of children with frequently relapsing steroid-dependent nephrotic syndrome [1,2,[7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Influence of Prolonged Corticosteroid Therapy on the Outcome of Steroid-Responsive Nephrotic Syndrome

Matsukura

Inaba²,

Shinozaki³

et al. 2001

Am J Nephrol

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Eighty-six patients (59 males and 27 females) diagnosed with steroid-responsive nephrotic syndrome during childhood were identified. The patients were 20–40 years of age (mean 27.0 ± 5.0) with a mean follow-up period of 19.5 ± 5.9 years. All patients had been treated with a long-term tapering corticosteroid therapy. Thirty patients had also received a course of cyclophosphamide (2 mg/kg/day for 12 weeks). Sixty-six had achieved sustained remission off corticosteroids, while 20 were still receiving corticosteroids to maintain remission. None of the 86 patients had proteinuria or renal insufficiency at the time of the study. Mean final heights in males and females were similar (–0.51 ± 1.21 and –0.23 ± 1.16 standard deviation score). Mean final height of 20 steroid-dependent patients was significantly less than that of 66 in remission off corticosteroids (p < 0.005). Ten cyclophosphamide-treated patients got married and 9 had at least 1 healthy child. In children with steroid-responsive nephrotic syndrome, the need for corticosteroid therapy to maintain remission may be associated with decreased adult height. Patients who received a 12-week course of cyclophosphamide are likely to be normally fertile as adults.

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Long-term dwarfing effects of corticosteroid treatment for childhood nephrosis.

Cited by 65 publications

References 21 publications

Alteration of Cartilage Glycosaminoglycan Protein Acceptor by Somatomedin and Cortisol

Alteration of Cartilage Glycosaminoglycan Protein Acceptor by Somatomedin and Cortisol

Can Growth Hormone Treatment Improve the Growth Retardation in Children Associated with Steroid Dependent Nephrotic Syndrome

Influence of Prolonged Corticosteroid Therapy on the Outcome of Steroid-Responsive Nephrotic Syndrome

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