Long-Term Clinical Follow-Up After Successful Repeat Percutaneous Intervention for Stent Restenosis

Reimers, Bernhard; Moussa, Issam; Akiyama, Tatsuro; Tucci, G; Ferraro, Massimo; Martini, G.; Blengino, Simonetta; Mario, Carlo Di; Colombo, Antonio

doi:10.1016/s0735-1097(97)00142-3

Cited by 167 publications

(84 citation statements)

References 30 publications

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“…These results suggested that the intrinsic apoptotic pathway was induced in VSMCs that were exposed to ultrasound. The proliferation and apoptosis of VSMCs play important roles in the pathologic restenosis of blood vessels after percutaneous transluminal angioplasty and stenting (Reimers et al, 1997). Therefore, ultrasound treatment may potentially be considered as a new therapeutic tool for intimal hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

“…In this process, the increased proliferation and migration of VSMCs are undoubtedly required and potent for vascular repair (Beamish et al, 2010). However, the excessive proliferation of VSMCs can aggravate vascular injury, which was reported to occur in restenosis after angioplasty (Reimers et al, 1997). Therefore, it is important to find strategies to prevent the excessive proliferation or induce the apoptosis of VSMCs to a certain extent that does not compromise the normal cellular expansion.…”

Section: Introductionmentioning

confidence: 99%

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Low-frequency ultrasound induces apoptosis of rat aortic smooth muscle cells (A7r5) via the intrinsic apoptotic pathway

et al. 2014

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ABSTRACT. Ultrasound, a non-invasive therapy method, is a potential tool for medical applications, but its biological effects on vascular smooth muscle cells (VSMCs) have not been characterized. The aim of this study was to explore the effect and possible apoptotic mechanism of VSMCs that were induced by low-frequency ultrasound (LFU). Cell viability and apoptosis of A7r5 cells were evaluated after treating A7r5 cells with a continuous 45-kHz 1.0-W/cm 2 ultrasound (exposure time of 0, 10, 20, 30, and 35 s) by MTT assay and flow cytometry. At the optimum ultrasound exposure condition (30 s), gene chip analysis was performed, and the apoptotic signaling pathway was confirmed by reverse transcription-polymerase chain reaction and Western blot. As measured by flow cytometry, LFU significantly induced A7r5 cell apoptosis. Comparing the ultrasound group with the control group, the protein expression of caspase-9 and caspase-3 was increased by 50 and 57%, respectively; the caspase-3 mRNA level was increased by 37.5%. These findings indicate that an intrinsic pathway plays a major role in apoptosis that is induced by LFU and that LFU can induce A7r5 cell apoptosis via caspase-9-and caspase-3-dependent pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low-frequency ultrasound induces apoptosis of rat aortic smooth muscle cells (A7r5) via the intrinsic apoptotic pathway

et al. 2014

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“…21,28 Thus, in-stent restenosis is an important clinical problem. Restenosis after stent implantation is mainly caused by neointimal proliferation through the stent struts.…”

Section: Discussionmentioning

confidence: 99%

Nocturnal Oxygen Desaturation as a Predictive Risk Factor for Coronary Restenosis After Coronary Intervention Serial Quantitative Coronary Angiography Study

Hayashi

Urushibata

Imamura

et al. 2005

Circ J

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Background Sleep-disordered breathing may affect coronary artery disease, so patients treated by percutaneous transluminal coronary angioplasty were studied to investigate the relationship between nocturnal oxygen desaturation (NOD) and the loss index. Methods and ResultsThe nocturnal oxygen desaturation index (ODI) was determined by means of a pulse oximeter in 35 patients with coronary artery disease treated by stent placement. The patients were divided into 3 groups according to ODI: <5 events/h (group N, n=6), between 5 and 14 events/h (group A, n=19), and ≥15 events/h (group B, n=10). The relationship between the ODI and loss index was examined in each group. The loss index, 0.27±0.23 in group N, 0.30±0.27 in group A, and 0.70±0.32 in group B, differed significantly between groups N and B (p=0.007). In all patients, the loss index showed a significant positive correlation with the ODI (R=0.585, p=0.002). Conclusions These findings suggest that NOD may be an important contributor to coronary restenosis in patients treated with stent placement. (Circ J 2005; 69: 1320 -1326

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“…Studies have shown that focal in-body restenosis (type Ic [7]) constitutes a more benign pattern of in-stent restenosis, which can be effectively treated using conventional angioplasty (7)(8)(9). Conversely, other types of restenosis that are more frequently associated with procedural issues (eg, geographic miss, in the case of type Ib restenosis) or with aggressive neointimal proliferation may benefit from repeat SES implantation.…”

Section: Treatment Of In-ses Restenosismentioning

confidence: 99%

Symptomatic failure after sirolimus-eluting stent implantation: A rare but challenging condition

Fineschi¹,

Gori²,

Pierli³

et al. 2007

Canadian Journal of Cardiology

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Long-Term Clinical Follow-Up After Successful Repeat Percutaneous Intervention for Stent Restenosis

Abstract: In-stent balloon angioplasty for stent restenosis in native vessels seems to be an effective method in terms of a low long-term clinical event rate.

Cited by 167 publications

References 30 publications

Low-frequency ultrasound induces apoptosis of rat aortic smooth muscle cells (A7r5) via the intrinsic apoptotic pathway

Low-frequency ultrasound induces apoptosis of rat aortic smooth muscle cells (A7r5) via the intrinsic apoptotic pathway

Nocturnal Oxygen Desaturation as a Predictive Risk Factor for Coronary Restenosis After Coronary Intervention Serial Quantitative Coronary Angiography Study

Symptomatic failure after sirolimus-eluting stent implantation: A rare but challenging condition

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