2020
DOI: 10.1111/hel.12721
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Abstract: Background Penicillin‐allergic children who are infected with Helicobacter pylori constitute a relatively common subgroup. We aimed to study the short‐term and long‐term effects of bismuth quadruple therapy on gut microbiota in penicillin‐allergic children. Methods We prospectively recruited treatment‐naive children with H pylori infection and H pylori‐negative asymptomatic children as healthy controls. Patients received 14‐day bismuth quadruple therapy consisting of omeprazole, clarithromycin, metronidazole, … Show more

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Cited by 23 publications
(30 citation statements)
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References 62 publications
(61 reference statements)
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“…The short-term changes in gut microbiota after these therapies have been reported in nine studies using culture-independent approaches. 54 , 101 , 112 , 119–124 All of these studies showed significant perturbations in the diversity and composition of gut microbiota immediately after H. pylori eradication. Long‐term changes (over six months) were reported in seven studies, although most had low numbers of cases.…”
Section: Helicobacter Pylori and Colonic Microbiotamentioning
confidence: 96%
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“…The short-term changes in gut microbiota after these therapies have been reported in nine studies using culture-independent approaches. 54 , 101 , 112 , 119–124 All of these studies showed significant perturbations in the diversity and composition of gut microbiota immediately after H. pylori eradication. Long‐term changes (over six months) were reported in seven studies, although most had low numbers of cases.…”
Section: Helicobacter Pylori and Colonic Microbiotamentioning
confidence: 96%
“…Compared to studies investigating the effect of H. pylori on human gastric microbiota, relatively few studies have addressed the influence of H. pylori on colonic microbiota (summarized in Table 3, Figure 1(b)). 47,54,[98][99][100][101][102][103][104][105][106][107][108][109][110][111][112] Most studies have focused on the consequences of H. pylori eradication therapy. [98][99][100][101] Earlier studies using culturebased approaches [98][99][100] or fluorescent in situ hybridization 99 suggested different compositions of gut microbiota among H. pylori-infected and uninfected individuals.…”
Section: Helicobacter Pylori and Colonic Microbiota In Humansmentioning
confidence: 99%
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“…The increased antibiotic resistance in H. pylori will further reduce patients' quality of life and increase the cost-effectiveness of antibiotic-based therapy [ 8 ]. In addition, prolonged eradication therapy for H. pylori infection also leads to dysbiosis of the intestinal microbiota and increases the expression of resistance genes, which may further induce various diseases [ 12 , 15 , 16 , 29 ]. However, with the emergence of WMT and fecal suspension capsules, the safety and convenience of WMT have been significantly improved [ 23 , 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have shown that H. pylori infection causes gastrointestinal microbiota disorder, and this change is reversible after H. pylori eradication [ 12 14 ]. In addition, antibiotic-based treatments for H. pylori eradication have been shown to cause gut microbiota dysbiosis and lead to the increase of erm (B) gene (a gene encoding erythromycin-resistant methylase), which would compromise the efficacy of eradiation therapy regimens including a macrolide [ 12 , 15 , 16 ]. Therefore, it may be possible to reverse the colonization of H. pylori by restoring the gastrointestinal microbiota.…”
Section: Introductionmentioning
confidence: 99%