2016
DOI: 10.1016/j.celrep.2015.12.042
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Abstract: Calorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum corticosterone and HSP70 expression in rodents. However, less is known regarding the effects of CR on these factors in humans. Serum cortisol and molecular chaperones and autophagic proteins were measured in the skeletal muscle of subjects on CR diets for 3-15 years and in control volunteers. Serum cortisol was higher in the CR group than in age-matched sedentary and endurance athlete groups (15.6 ± 4.6 ng/dl versus 12… Show more

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Cited by 126 publications
(85 citation statements)
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“…FOXO activation resulted in up-regulation of several anti-aging genes, including the antioxidant enzyme SOD2, the DNA repair transcript DDB1, and the autophagy genes beclin-1 and LC3 (Mercken et al, 2013). Consistent with some of these gene expression changes, beclin-1 and LC3 protein levels were significantly higher in the skeletal muscle of the CR volunteers (Yang et al, 2016). Moreover, key stress-induced cytosolic chaperones transcript and protein levels, such as HSP70 and GRP78, were significantly higher in the CR skeletal muscle (Yang et al, 2016).…”
Section: Insights From Observational Studies Of Severe Calorie Restrisupporting
confidence: 57%
See 1 more Smart Citation
“…FOXO activation resulted in up-regulation of several anti-aging genes, including the antioxidant enzyme SOD2, the DNA repair transcript DDB1, and the autophagy genes beclin-1 and LC3 (Mercken et al, 2013). Consistent with some of these gene expression changes, beclin-1 and LC3 protein levels were significantly higher in the skeletal muscle of the CR volunteers (Yang et al, 2016). Moreover, key stress-induced cytosolic chaperones transcript and protein levels, such as HSP70 and GRP78, were significantly higher in the CR skeletal muscle (Yang et al, 2016).…”
Section: Insights From Observational Studies Of Severe Calorie Restrisupporting
confidence: 57%
“…Consistent with some of these gene expression changes, beclin-1 and LC3 protein levels were significantly higher in the skeletal muscle of the CR volunteers (Yang et al, 2016). Moreover, key stress-induced cytosolic chaperones transcript and protein levels, such as HSP70 and GRP78, were significantly higher in the CR skeletal muscle (Yang et al, 2016). These data strongly suggest that CR in humans is associated with an increase in key molecular chaperones and autophagic mediators involved in cellular protein quality control and removal of dysfunctional proteins and organelles.…”
Section: Insights From Observational Studies Of Severe Calorie Restrisupporting
confidence: 57%
“…It is common knowledge that a balanced dietary regimen coupled with regular exercise preserves organismal fitness and can postpone several, if not all, of the manifestations of ageing. Accumulating evidence suggests that various beneficial effects of a healthy lifestyle depend (at least in part) on the activation of autophagy 240 . It will therefore be interesting to see whether CRMs or other pharmacological activators of autophagy can be used to extend lifespan (TABLE 2).…”
Section: Autophagy As a Therapeutic Targetmentioning
confidence: 99%
“…To this end, we recruited and studied 12 middle‐aged (61.7 ± 8.4 years), weight‐stable very lean (BMI = 19.1 ± 1.3 kg/m 2 ) members of the Calorie Restriction Society who have been practicing ~30% CR with adequate nutrition (at least 100% of RDI for each nutrient) for an average of 10.1 years (Most, Tosti, Redman & Fontana, 2017; Yang et al., 2016) and a control group of 12 nonobese (BMI = 27.4 ± 2.5 kg/m 2 ) age‐matched sedentary controls eating a typical Western diet (WD‐o; Figure 2a). Furthermore, we compared the CR and WD‐o groups with younger (24.3 ± 2.0 years, range 21–27 years) nonobese (BMI = 25.7 ± 0.9 kg/m 2 ) humans (WD‐y).…”
Section: Introductionmentioning
confidence: 99%