Long-term air pollution exposure and serum lipids and blood sugar: A longitudinal cohort study from the electricity generating authority of Thailand study

Paoin, Kanawat; Ueda, Kayo; Vathesatogkit, Prin; Ingviya, Thammasin; Buya, Suhaimee; Phosri, Arthit; Seposo, Xerxes; Thongmung, Nisakron; Yingchoncharoen, Teerapat; Honda, Akira; Takano, Hirohisa; Sritara, Piyamitr

doi:10.1016/j.atmosenv.2021.118515

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…After controlling the influence of gas pollutants, it was found that the influence of inhalable particulate matter becomes stronger, indicating that inhalable particulate matter was the main influencing factor [31]. Many studies were consistent with the research results of this study [32,33]. Toxicological studies had shown that inhalable particles may cause inflammatory response and oxidative stress response and induce hepatocyte lipid degeneration [34,35].…”

Section: Discussionsupporting

confidence: 83%

Associations of environmental factors with total cholesterol level of middle-aged and elderly people in China

Pei

et al. 2022

BMC Public Health

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Background Dyslipidemia is a key factor causing cardio cerebrovascular diseases, and the total cholesterol (TC) is an important lipid indicator among them. Studies have shown that environmental factors have a strong association with TC levels. Previous studies only focused on the seasonal variation of TC level and the short-term effects of some environmental factors on TC level over time, and few studies explored the geographical distribution of TC level and quantified the impact of environmental factors in space. Methods Based on blood test data which was from China Health and Retirement Longitudinal Study (Charls) database, this study selected the TC level test data of middle-aged and elderly people in China in 2011 and 2015, and collected data from 665 meteorological stations and 1496 air pollutant monitoring stations in China. After pretreatment, the spatial distribution map of TC level was prepared and the regional statistics were made. GeoDetector and geographically weighted regression (GWR) were used to measure the relationship between environmental factors and TC level. Results The TC level of middle-aged and elderly in China was higher in females than in males, and higher in urban areas than in rural areas, showing a clustered distribution. The high values were mainly in South China, Southwest China and North China. Temperature, humidity, PM10 and PM2.5 were significant environmental factors affecting TC level of middle-aged and elderly people. The impact of pollutants was more severe in northern China, and TC level in southern China was mainly affected by meteorological factors. Conclusions There were gender and urban-rural differences in TC levels among the middle-aged and elderly population in China, showing aggregation in geographical distribution. Meteorological factors and air pollutants may be very important control factors, and their influencing mechanism needs further study.

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Section: Discussionsupporting

confidence: 83%

Associations of environmental factors with total cholesterol level of middle-aged and elderly people in China

Pei

et al. 2022

BMC Public Health

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“…One week and one month after the end of exposure, the body weight gain (BWG) of these mice were increased by 1.05, 1.07, 1.09-fold and 1.12, 1.16, 1.23-fold respectively [16]. Data from the 2014 US National Health Interview Survey showed that exposure to high levels of occupational noise for 15 years or longer increased the risk of obesity by 46% [17]. In contrast, noise exposure was also reported to suppress the BWG.…”

Section: Introductionmentioning

confidence: 99%

PPARα suppresses low-intensity-noise-induced body weight gain in mice: the aggravation of fatty liver is covered up

Liu

Yan

Luo

et al. 2023

Preprint

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Background As the second risky environmental pollution, noise imposes threats to human health. Exposure to high-intensity noise causes hearing impairment, psychotic disorders, endocrine modifications. However, the relationship among low-intensity noise, obesity and lipid-regulating nuclear factor PPARα is not yet clear.Methods In this study, wild-type (WT) and Pparα-null (KO) mice on a high-fat diet (HFD) were exposed to 75 dB noise for 12 weeks to explore the effect of low-intensity noise on obesity development and the role of PPARα. 3T3-L1 cells were treated with dexamethasone (DEX) to verify the down-stream effect of hypothalamic-pituitary-adrenal (HPA) axis activation on the adipose tissues.Results The average body weight gain (BWG) of WT mice on HFD exposed to noise was inhibited by 34.6%, which was not observed in KO mice. The mass and adipocyte size of adipose tissues accounted for the above difference of BWG tendency. In WT mice on HFD, the adrenocorticotropic hormone level was increased by the noise challenge. The aggravation of fatty liver by noise exposure occurred in both mouse lines, and the transport of hepatic redundant lipid to adipose tissues were similar. The lipid metabolism in adipose tissue driven by HPA axis accorded with the BWG inhibition, validated in 3T3-L1 adipogenic stem cell model.Conclusion Chronic exposure to low-intensity noise aggravated fatty liver in both WT and KO mice. BWG inhibition was observed only in WT mice, which covered up the aggravation of fatty liver by noise exposure. Lipid metabolism in adipose tissues driven by HPA axis activation contributed to the disassociation of BWG and fatty liver development in WT mice.

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Associations between residential greenness and air pollution and the incident metabolic syndrome in a Thai worker cohort

Paoin,

Pharino,

Vathesatogkit

et al. 2023

Int J Biometeorol

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Long-term air pollution exposure and serum lipids and blood sugar: A longitudinal cohort study from the electricity generating authority of Thailand study

Cited by 6 publications

References 46 publications

Associations of environmental factors with total cholesterol level of middle-aged and elderly people in China

Associations of environmental factors with total cholesterol level of middle-aged and elderly people in China

PPARα suppresses low-intensity-noise-induced body weight gain in mice: the aggravation of fatty liver is covered up

Associations between residential greenness and air pollution and the incident metabolic syndrome in a Thai worker cohort

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