Long-Term Additive Prognostic Value of Thallium-201 Myocardial Perfusion Imaging Over Clinical and Exercise Stress Test in Low to Intermediate Risk Patients

Vanzetto, Gérald; Ormezzano, Olivier; Fagret, Daniel; Comet, M.; Denis, B; Machecourt, J

doi:10.1161/01.cir.100.14.1521

Cited by 171 publications

(84 citation statements)

References 26 publications

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“…The abnormalities were predominantly observed at rest, indicating persistent myocardial injury. It has to be stressed that perfusion defects revealed by SPECT strongly affect the prognosis in non-autoimmune populations [16,17]. We found only two studies that assessed myocardial perfusion in PAPS patients.…”

Section: Discussionmentioning

confidence: 89%

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Myocardial Ischaemia, Coronary Atherosclerosis and Pulmonary Pressure Elevation in Antiphospholipid Syndrome Patients

Padjas¹,

Płazak²,

Celińska-Löwenhoff³

et al. 2016

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 89%

“…The presence of atherosclerotic plaques and myocardial perfusion defects in a SPECT study are strong predictors of death [16,17,24,25]. The mechanism of these abnormalities, in which microthrombosis might play a major role, should direct our attention to thrombosis prevention.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Ischaemia, Coronary Atherosclerosis and Pulmonary Pressure Elevation in Antiphospholipid Syndrome Patients

Padjas¹,

Płazak²,

Celińska-Löwenhoff³

et al. 2016

Adv Clin Exp Med

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“…(70,71) Fixed and reversible stress perfusion defects predict hard events; still, patients with extensive stress-induced defects are the ones at higher risk. (57)(58)(59)(60)62,63,65,(71)(72)(73) Perfusion defects are not the only determinants of risk. When MPI is performed with 201-Tl, abnormally increased tracer uptake of the FIGURE 1: Stress-rest MPI studies showing severe apical, apical-anterior, midanterior, mid-anteroseptal and basal-anteroseptal segments, stress induced ischemia (Short axis, vertical long axis and horizontal long axis views.…”

Section: Discussionmentioning

confidence: 99%

Value of nuclear cardiology for the diagnosis and risk stratification of coronary artery disease

Libhaber

Vangu

2017

SAHJ

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Value of nuclear cardiology for the diagnosis and risk stratifi cation of coronary artery disease 106 INTRODUCTIONNuclear cardiology has undergone an outstanding growth during the last 25 years.With technical improvements and new radiopharmaceuticals, higher sensitivity and specifi city of myocardial perfusion imaging (MPI) scans has been achieved for detection and evaluation of ischemic heart disease.MPI is performed with the administration of radiopharmaceuticals which are taken up by the myocardial cells. Different radiotracers can be used, such as: 99m Tc- Sestamibi, 99m Tc-Tetrofosmin, etc.The investigation is performed at rest and stress, providing semiquantitative information on areas of myocardial infarction and ischemia.Beller et al. showed in the "anginal cascade"(1) that, with increasing stress time and myocardial oxygen demand, ischemic ST depression and anginal symptoms appear after fl ow heterogeneity, regional myocardial dysfunction, signifi cant perfusion defects and global left ventricular dysfunction. This accounts for the increased sensitivity, specifi city and accuracy of MPI over symptoms and stress ECG in the diagnosis and follow-up of coronary artery disease.It has developed into one of the most contributory fi elds in clinical decision making for the detection and risk stratifi cation in patients with suspected and known coronary artery disease. USE OF MYOCARDIAL PERFUSION SCINTIGRAPHY IN THE CLINICAL SETTINGMyocardial perfusion SPECT (single photon emission computed tomography) is a widely utilized noninvasive imaging modality for the diagnosis and management of ischemic heart disease. This modality allows a three-dimensional assessment and quantitation of the myocardium and functional assessment through ECG-gating of the perfusion images. Vol. 5, No. 3, 2008 There are several indications for the use of myocardial perfusion SPECT, whether it is for a patient who is not known to have coronary artery disease and the aim is confi rm or rule out the diagnosis, or in the patient with known ischemic heart disease, whether symptomatic or not, for risk-stratifi cation (Table 1). Indications for myocardial perfusion scintigraphy If the patient does not have diagnosis of CADTo exclude or diagnose CAD in patients with suspected CAD As a screening test in those with intermediate or high risk of CAD, e.g. familial hyperlipidemia, type II diabetes mellitus, family history of CAD, and those with atypical symptoms of ischemic heart disease (IHD). In patients with high pretest likelihood for CAD, MPI is mainly useful for risk stratifi cation purposes.In patients with non-diagnostic electrocardiography (ECG), at rest or post-stress. While there are many causes for an abnormal baseline ECG (Table 2), STRESS-ECG is frequently not conclusive. (range 17 to 100).Patients who are at risk of developing peri or postoperative cardiovascular events, i.e. peripheral vascular disease, aortic aneurysm, and the elderly.Acute chest pain -diagnosis of CAD.LBBB can induce perfusion defect in the basal ante...

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“…While thallium-201, formerly widely used in myocardial scintigraphy [44], has practically disappeared from the radionuclide toolbox; it is almost completely replaced by technetium-99m perfusion agents. Indium-111 continues to be utilized almost exclusively for the labelling of the somatostatin analogue octreotide (Octreoscan©) [45].…”

Section: Gamma Emitters and Spect Imagingmentioning

confidence: 99%

Basic Premises to Molecular Imaging and Radionuclide Therapy – Part 1

Mansi¹,

Kitson²,

Cuccurullo³

et al. 2014

J Diagn Imaging Ther

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This manuscript is a complementary article to an accompanying paper, published in a forthcoming issue, which will give an overview on the central role of chelation in labelling radiocompounds; either for imaging and/or for radionuclide therapy. In order to facilitate a better understanding of the importance of Chelator-Based Imaging & Therapy, we will briefly discuss in this publication -which is partially intended as an introduction to the second paper -which contains the major basic principles of molecular imaging and radionuclide therapy. Although these issues are of interest in the general field of Nuclear Medicine; since the chelation process involves the labelling with radiometals; we aim to highlight examples of this category in this paper which concern this class of nuclides in this particular issue.

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Long-Term Additive Prognostic Value of Thallium-201 Myocardial Perfusion Imaging Over Clinical and Exercise Stress Test in Low to Intermediate Risk Patients

Abstract: The incremental predictive value of SPECT is maintained over 6 years and is particularly relevant after positive, strongly positive, and nondiagnostic ETT.

Cited by 171 publications

References 26 publications

Myocardial Ischaemia, Coronary Atherosclerosis and Pulmonary Pressure Elevation in Antiphospholipid Syndrome Patients

Myocardial Ischaemia, Coronary Atherosclerosis and Pulmonary Pressure Elevation in Antiphospholipid Syndrome Patients

Value of nuclear cardiology for the diagnosis and risk stratification of coronary artery disease

Basic Premises to Molecular Imaging and Radionuclide Therapy – Part 1

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