Long-term (37 years) clinical outcome of older women with early operable primary breast cancer managed in a dedicated clinic

Abstract

In the recent decade, while surgery became the predominant treatment, a significant proportion of patients had non-operative therapies, selection of which was based on multidisciplinary assessment in the clinic. This management approach appears to produce excellent clinical outcome, which is significantly better than that in earlier period.

Biology of primary breast cancer in older women treated by surgery: with correlation with long-term clinical outcome and comparison with their younger counterparts

“…In all, 813 patients underwent primary surgery (with optimal adjuvant therapy as per unit policy at the time (Syed et al , 2011a). After excluding 238 tumour samples that were checked and confirmed to have insufficient materials, a total of 575 good quality formalin-fixed paraffin-embedded surgical specimens were available for TMA construction.…”

“…We have recently reported on the conventional pathological features and their correlation with long-term clinical outcome in older women with early operable primary breast cancer, regardless of primary therapy (Syed et al , 2011a). …”

“…Comparison was also made with their younger counterparts (Abd El-Rehim et al , 2005; Aleskandarany et al , 2011). The focus of this study was on biomarkers analysed using tissue microarrays (TMAs) and partitional clustering analysis, rather than conventional pathological features as reported (Syed et al , 2011a). …”

Management of Operable Primary Breast Cancer in Older Women

“…This may not necessarily include participation of the patient and their family at the time of discussion. Thus it evolves the concept of a specialized clinic developed solely for older women with primary operable breast cancer [84]. This design involves meeting of members of the relevant disciplines (e.g., clinicians and specialist nurses), the patient and their family, in a dedicated clinic, available at every stage of the disease process, including diagnosis, treatment decision and follow-up.…”

El cáncer como problema de salud pública en el Perú

“…Este porcentaje puede llegar a ser mayor en algunas neoplasias. Por ejemplo, en el cáncer de cérvix en estadios iniciales, el porcentaje de curación se aproxima al 100%, y en el cáncer de mama temprano, es mayor al 95% (3) . Estos dos cánceres son las más frecuentes en nuestro medio en el sexo femenino, contribuyendo con más del 50% de la incidencia total de cáncer en ambos sexos.…”