Long Noncoding RNAs PTPRG Antisense RNA 1 Targets Cyclin D1 to Facilitate Cell Proliferation in Lung Adenocarcinoma

Yang, Xue; Diao, Mingqiang; Lyu, Jing; Li, Kang; He, Long; Chen, Junfeng; Li, Xiangguo

doi:10.1089/cbr.2021.0168

Cited by 10 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these 8 lncRNAs, OGFRP1 has been reported to be the oncogene in NSCLC 39 . PTPRG-AS1 was reported to increased the proliferation in LUAD 40 and reduced the radiosensitivity in NSCLC as well 41 . These previous studies confirmed that 8 lncRNAs have the potential to affect the development of LUAD and LUSC.…”

Section: Discussionmentioning

confidence: 99%

Construction and validation of a cuproptosis-related lncRNA signature for the prediction of the prognosis of LUAD and LUSC

Wang

Xiao

2023

Sci Rep

View full text Add to dashboard Cite

Lung cancer is one of the most prevalent malignant tumors worldwide, with lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) accounting for the majority of cases. Cuproptosis, tumor immune microenvironment (TIME) and long non-coding RNA (lncRNA) have been demonstrated to be associated with tumorigenesis. The objective of the present study was to develop a novel cuproptosis-related lncRNA signature to assess the association between cuproptosis and TIME in patients with LUAD or LUSC and to predict prognosis. Based on the outputs of the least absolute shrinkage and selection operator regression model, a cuproptosis-related lncRNA signature was developed. Kaplan–Meier survival curves were generated to confirm the predictive ability of the signature. Univariate and multivariate analysis was also performed to determine the association between overall survival and this signature and other clinical characteristics, and a nomogram was created. Additionally, the relationship between the signature, TIME, tumor mutation burden and m6A methylation was established. The results of the present study revealed that 8 cuproptosis-related lncRNAs were associated with the prognosis of patients with LUAD and LUSC. This novel cuproptosis-related lncRNA signature is associated with TIME and m6A methylation in LUAD and LUSC and can predict prognosis with accuracy.

show abstract

Section: Discussionmentioning

confidence: 99%

Construction and validation of a cuproptosis-related lncRNA signature for the prediction of the prognosis of LUAD and LUSC

Wang

Xiao

2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Among these 8 lncRNAs, OGFRP1 has been reported to be the oncogene in NSCLC 29,30 . PTPRG-AS1 was reported to increased the proliferation in LUAD 31 and reduced the radiosensitivity in NSCLC as well 32 . These previous studies con rmed that 8 lncRNAs have the potential to affect the development of LUAD and LUSC.…”

Section: Discussionmentioning

confidence: 99%

Construction and validation of a cuproptosis-related lncRNA signature for the prediction of the prognosis of LUAD and LUSC

Wang

Xiao

Li³

2022

Preprint

View full text Add to dashboard Cite

Lung cancer is one of the most prevalent malignant tumors worldwide, with lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) accounting for the majority of cases. Cuproptosis, tumor immune microenvironment (TIME) and long non-coding RNA (lncRNA) have been demonstrated to be associated with tumorigenesis. The objective of the present study was to develop a novel cuproptosis-related lncRNA signature to assess the association between cuproptosis and TIME in patients with LUAD or LUSC and to predict prognosis. Based on the outputs of the least absolute shrinkage and selection operator regression model, a cuproptosis-related lncRNA signature was developed. Kaplan-Meier survival curves were generated to confirm the predictive ability of the signature. Univariate and multivariate analysis was also performed to determine the association between overall survival and this signature and other clinical characteristics, and a nomogram was created. Additionally, the relationship between the signature, TIME, tumor mutation burden and m6A methylation was established. The results of the present study revealed that 8 cuproptosis-related lncRNAs were associated with the prognosis of patients with LUAD and LUSC. This novel cuproptosis-related lncRNA signature is associated with TIME and m6A methylation in LUAD and LUSC and can predict prognosis with accuracy.

show abstract

“…Direct bindings between the components of the triplet are established using the luciferase test, RNA-binding protein immunoprecipitation (RIP) assay, and RNA pull-down assay. In some works, the authors confirmed the functional significance of these interactions not only in cell cultures but also with the use of model animals, usually immunodeficient mice (e.g., [ 55 , 56 ]). Some studies also elucidated the effect of lncRNA and interactome, or in other words, the lncRNA/miRNA/mRNA axis, on the survival rate and response to chemotherapy in patients.…”

Section: Long Non-coding Rnas In Dysregulation Of Mir-124 Target Gene...mentioning

confidence: 93%

“…Other approaches exist (e.g., [ 54 ]). Then, the bioinformatically identified transcriptome correlations are confirmed experimentally by analyzing the levels of RNAs of all three types in a representative set of cancer samples and evaluation of the expected expression level relationship (e.g., [ 55 , 56 ]). Further, functional studies are applied on cell lines of this type of cancer, which, in short, include transfection of synthesized RNAs into cells, artificial suppression or overexpression of triplet components, loss and gain of function, analysis of physiological changes in cell culture (as the level of proliferation and apoptosis, migration and cell invasion).…”

Section: Long Non-coding Rnas In Dysregulation Of Mir-124 Target Gene...mentioning

confidence: 99%

“…Axes were also identified involving newer, recently discovered lncRNAs and targets, such as PTPRG-AS1 (protein tyrosine phosphatase, receptor type, G (PTPRG) Antisense RNA 1). This lncRNA is involved in two axes: PTPRG-AS1/miR-124-3p/CCND1 in lung adenocarcinoma and PTPRG-AS1/miR-124-3/LHX2 in nasopharyngeal carcinoma, which promote cell proliferation, cell cycle in vitro/in vivo, moreover, activation of LHX2 (LIM Homeobox 2) induces Notch pathway and reduces radiosensitivity [ 56 , 89 ].…”

Section: Long Non-coding Rnas In Dysregulation Of Mir-124 Target Gene...mentioning

confidence: 99%

See 1 more Smart Citation

Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs

Брага

Фридман

Burdennyy

et al. 2022

IJMS

View full text Add to dashboard Cite

A decrease in the miR-124 expression was observed in various epithelial cancers. Like a classical suppressor, miR-124 can inhibit the translation of multiple oncogenic proteins. Epigenetic mechanisms play a significant role in the regulation of miR-124 expression and involve hypermethylation of the MIR-124-1/-2/-3 genes and the effects of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) according to the model of competing endogenous RNAs (ceRNAs). More than 40 interactomes (lncRNA/miR-124/mRNA) based on competition between lncRNAs and mRNAs for miR-124 binding have been identified in various epithelial cancers. LncRNAs MALAT1, NEAT1, HOXA11-AS, and XIST are the most represented in these axes. Fourteen axes (e.g., SND1-IT1/miR-124/COL4A1) are involved in EMT and/or metastasis. Moreover, eight axes (e.g., OIP5-AS1/miR-124-5p/IDH2) are involved in key pathways, such as Wnt/b-catenin, E2F1, TGF-β, SMAD, ERK/MAPK, HIF-1α, Notch, PI3K/Akt signaling, and cancer cell stemness. Additionally, 15 axes impaired patient survival and three axes reduced chemo- or radiosensitivity. To date, 14 cases of miR-124 regulation by circRNAs have been identified. Half of them involve circHIPK3, which belongs to the exonic ecircRNAs and stimulates cell proliferation, EMT, autophagy, angiogenesis, and multidrug resistance. Thus, miR-124 and its interacting partners may be considered promising targets for cancer therapy.

show abstract

Long Noncoding RNAs PTPRG Antisense RNA 1 Targets Cyclin D1 to Facilitate Cell Proliferation in Lung Adenocarcinoma

Cited by 10 publications

References 28 publications

Construction and validation of a cuproptosis-related lncRNA signature for the prediction of the prognosis of LUAD and LUSC

Construction and validation of a cuproptosis-related lncRNA signature for the prediction of the prognosis of LUAD and LUSC

Construction and validation of a cuproptosis-related lncRNA signature for the prediction of the prognosis of LUAD and LUSC

Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs

Contact Info

Product

Resources

About