Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A

He, Qin; Yang, Shuangyan; Gu, Xiuge; Li, Mengying; Wang, Chunling; Wei, Fulan

doi:10.1038/s41419-018-0484-2

Cited by 75 publications

(76 citation statements)

References 61 publications

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“…Recently, lncRNAs have been reported to regulate bone formation and osteogenic differentiation of PDL stem cells. He et al [21] revealed that lncRNA TUG1 promoted osteogenic differentiation of PDL stem cells, and the mechanism might be related to Lin28A. Peng et al [22] suggested that lncRNA ANCR inhibited bone formation of PDL stem cells through miR-758/Notch2.…”

Section: Discussionmentioning

confidence: 99%

Knockdown of DANCR reduces osteoclastogenesis and root resorption induced by compression force via Jagged1

Zhao

Han

et al. 2019

Cell Cycle

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LncRNA DANCR has been proven to be involved in osteoblast differentiation. This study aims to investigate the role of DANCR in osteoclast formation and root resorption in periodontal ligament (PDL) cells induced by compression force (CF). Rat orthodontic tooth movement (OTM) model was established. The molecules expressions in the areas of root resorption form OTM model were measured. The number of osteoclasts was measured using Tartrate-resistant acid phosphatase (TRAP) staining. The bone resorption was detected using pit formation assay. We showed that the expression of DANCR and Jagged1 protein was increased in rat OTM model and human periodontal ligament (hPDL) cells treated with CF, and CF increased the production of Jagged1, RANKL, and IL-6 from the hPDL cells. Moreover, DANCR could positively regulate Jagged1 protein expression. Knockdown of DANCR could change the promotion effect of CF on osteoclastogenesis and bone resorption in vitro and in vivo experiments, while overexpression of Jagged1 reversed si-DANCR effect. Taken together, knockdown of DANCR reduced osteoclast formation and root resorption induced by CF via Jagged1.

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Section: Discussionmentioning

confidence: 99%

Knockdown of DANCR reduces osteoclastogenesis and root resorption induced by compression force via Jagged1

Zhao

Han

et al. 2019

Cell Cycle

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“…The knockdown of the gene inhibited the osteogenic potential of periodontal ligament stem cells. Thus, TUG1 may regulate osteoblast differentiation by regulating the expression of Lin28 20 . Liao et al proposed that lncRNAH19 serves as the mediator of BMP9 signal transduction by regulating the Notch signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Screening and functional identification of lncRNAs in antler mesenchymal and cartilage tissues using high-throughput sequencing

Chen

Jiang

et al. 2020

Sci Rep

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Long non-coding RNA (lncRNA) is a transcription product of the mammalian genome that regulates the development and growth in the body. The present study aimed to analyze the expression dynamics of lncRNA in sika antler mesenchymal and cartilage tissues by high-throughput sequencing. Bioinformatics was applied to predict differentially expressed lncRNAs and target genes and screen lncRNAs and mRNAs related to osteogenic differentiation, cell proliferation, and migration. Finally, the expression of the lncRNAs and target genes were analyzed by qRT-PCR. The results showed that compared to the cartilage tissue, the transcription levels of lncRNA and mRNA, 1212 lncRNAs and 518 mRNAs, in mesenchymal tissue were altered significantly. Thus, a complex interaction network was constructed, and the lncRNA-mRNA interaction network correlation related to osteogenic differentiation, cell proliferation, and migration was analyzed. Among these, the 26 lncRNAs and potential target genes were verified by qRT-PCR, and the results of qRT-PCR were consistent with high-throughput sequencing results. These data indicated that lncRNA promotes the differentiation of deer antler mesenchymal tissue into cartilage tissue by regulating the related osteogenic factors, cell proliferation, and migration-related genes and accelerating the process of deer antler regeneration and development.

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“…Similarly, the pattern of TUG1 functioning encompassed from interacting with proteins to binding RNAs. He et al (32), reported TUG1 facilitated osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A. Zhang et al (33) presented TUG1 was required to target EZH2 occupancy and epigenetically modulate the expression of p15, p16, p21, p27 and p57, further regulated the cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA TUG1 promotes cardiac fibroblast transformation to myofibroblasts via miR‑29c in chronic hypoxia

et al. 2018

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Cardiac fibroblast‑myofibroblast transformation (FMT) contributes to the fibrotic deterioration evoked by chronic hypoxia. Growing evidence implicates long noncoding RNAs (lncRNAs) in various types of cardiac physiological and pathological processes, especially in cardiac fibrosis. In the present study, the lncRNA Taurine Upregulated Gene 1 (TUG1), reported as a regulator of hypoxia fibrosis in the lungs, was found to also be an important regulator of cardiac FMT. Specifically, the possible role of TUG1 in cardiac FMT and fibrosis under chronic hypoxia was investigated. It was revealed that the degree of fibrosis in heart tissues collected from congenital heart surgery patients with low pulse oxygen saturation and mice housed under chronic hypoxic and atmospheric pressure conditions was negatively correlated with pulse oxygen saturation. Moreover, TUG1 expression was positively correlated with the degree of fibrosis but negatively correlated with pulse oxygen saturation. Cardiac fibroblasts showed increased myofibroblast marker, collagen I and α‑SMA expression levels as the hypoxia time increased. TUG1 knockdown ameliorated the hypoxia‑induced FMT. A bioinformatics analysis predicted that TUG1 had miR‑29c binding sites in its 3'‑UTR and miR‑29c is a key regulator of cardiac fibrosis. The present study demonstrated that TUG1, along with miR‑29c, may contribute to cardiac FMT activation and promote fibrosis in chronic hypoxia.

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Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A

Cited by 75 publications

References 61 publications

Knockdown of DANCR reduces osteoclastogenesis and root resorption induced by compression force via Jagged1

Knockdown of DANCR reduces osteoclastogenesis and root resorption induced by compression force via Jagged1

Screening and functional identification of lncRNAs in antler mesenchymal and cartilage tissues using high-throughput sequencing

Long noncoding RNA TUG1 promotes cardiac fibroblast transformation to myofibroblasts via miR‑29c in chronic hypoxia

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