Long noncoding RNA PVT1 inhibits renal cancer cell apoptosis by up-regulating Mcl-1

Wu, Qingzhong; Yang, Fan; Yang, Zhenxing; Fang, Zhen; Fu, Wan-Lei; Chen, Wei; Liu, Xiaobing; Zhao, Jiang; Wang, Qingqing; Hu, Xiaoyan; Li, Longkun

doi:10.18632/oncotarget.21706

Cited by 26 publications

(42 citation statements)

References 30 publications

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“…It has been validated that lncRNA AK001796 could act as an effective treatment target and underlying prognostic factor for esophageal squamous cell carcinoma (ESCC) (Liu et al, 2018a). Interestingly, Wu et al also revealed that overexpressed lncRNA PVT1 was related to tumorigenesis and poor prognosis in cancers (Wu et al, 2017). In addition, FSCN1 was expressed at a high level in ESCC (Shang et al, 2018), and overexpression of FSCN1 led to poor prognosis in ESCC (Akanuma et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Retracted: Down‐regulation of long noncoding RNA PVT1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via microRNA‐145‐mediated inhibition of FSCN1

Shen

Liu

et al. 2019

Molecular Oncology

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Accumulating evidence has established that long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) is a tumor regulator in many cancers. Here, we aimed to investigate the possible function of lncRNA PVT1 in esophageal carcinoma (EC) via targeting of microRNA‐145 (miR‐145). Initially, microarray‐based gene expression profiling of EC was employed to identify differentially expressed genes. Moreover, the expression of lncRNA PVT1 was examined and the cell line presenting with the highest level of lncRNA PVT1 expression was selected for subsequent experiments. We then proceeded to examine interaction among lncRNA PVT1, FSCN1, and miR‐145. The effect of lncRNA PVT1 on viability, migration, invasion, apoptosis, and tumorigenesis of transfected cells was examined with gain‐of‐function and loss‐of‐function experiments. We observed that lncRNA PVT1 was robustly induced in EC. lncRNA PVT1 could bind to miR‐145 and regulate its expression, and FSCN1 is a target gene of miR‐145. Overexpression of miR‐145 or silencing of lncRNA PVT1 was revealed to suppress cell viability, migration, and invasion abilities, while also stimulating cell apoptosis. Furthermore, our in vivo results showed that overexpression of miR‐145 or silencing of lncRNA PVT1 resulted in decreased tumor growth in nude mice. In conclusion, our research reveals that down‐regulation of lncRNA PVT1 could potentially promote expression of miR‐145 to repress cell migration and invasion, and promote cell apoptosis through the inhibition of FSCN1. This highlights the potential of lncRNA PVT1 as a therapeutic target for EC treatment.

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Section: Discussionmentioning

confidence: 99%

Retracted: Down‐regulation of long noncoding RNA PVT1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via microRNA‐145‐mediated inhibition of FSCN1

Shen

Liu

et al. 2019

Molecular Oncology

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“…LncRNA UCA1 was reported to function as an oncogene in RCC through directly interacting with miR‐495 . Wu and colleagues indicated that lncRNA PVT1 knockdown promoted apoptosis, inhibited proliferation of RCC cells through enhancing Mcl‐1 mRNA stability . In the present study, we demonstrated that NBAT1 was significantly decreased in RCC cell lines.…”

Section: Discussionsupporting

confidence: 59%

LncRNA NBAT1 suppresses cell proliferation and migration via miR‐346/GSK‐3β axis in renal carcinoma

Xue

Wang

et al. 2019

IUBMB Life

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Long non-coding RNA (LncRNA) neuroblastoma associated transcript 1 (NBAT1) was demonstrated to be significantly downregulated in renal carcinoma (RCC) cells. However, the function and mechanism of NBAT1 in RCC is poorly understood. The expression of NBAT1 and glycogen synthase kinase-3β (GSK-3β)-mediated Wnt/βcatenin-related proteins were measured by quantitative real-time PCR (qRT-PCR) and western blotting in RCC cell lines. Cell viability, migration, and invasion were estimated by CCK-8 and Transwell assay. The association of miR-346 with GSK-3β expression was verified using luciferase assay. NBAT1 was significantly downregulated in RCC cells, and inhibited RCC cell proliferation, migration, and invasion. Furthermore, NBAT1 negatively regulated miR-346 expression. In addition, miR-346 overexpression and the knockdown of GSK-3β, a direct target of miR-346 could overturn the inhibitory effect of NBAT1 on Wnt/β-catenin signaling and cell proliferation, migration, and invasion. NBAT1 functioned as an endogenous sponge by competing for miR-346 binding to GSK-3β and therefore alleviated RCC cells.

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“…Plasmacytoma variant translocation 1 (PVT1) is transcribed from a locus adjacent to the MYC locus on human chromosome 8q24 [72]. The PVT1 is known to be up-regulated in some human tumors, such as HCC, ovarian cancer, malignant pleural mesothelioma, non-small cell lung cancer and renal cancer [122][123][124][125][126].…”

Section: Pvt1mentioning

confidence: 99%

LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

Kim

Park

Lee

2020

IJMS

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Long non-coding RNAs (lncRNAs) are emerging as important contributors to the biological processes underlying the pathophysiology of various human diseases, including hepatocellular carcinoma (HCC). However, the involvement of these molecules in chronic liver diseases, such as nonalcoholic fatty liver disease (NAFLD) and viral hepatitis, has only recently been considered in scientific research. While extensive studies on the pathogenesis of the development of HCC from hepatic fibrosis have been conducted, their regulatory molecular mechanisms are still only partially understood. The underlying mechanisms related to lncRNAs leading to HCC from chronic liver diseases and cirrhosis have not yet been entirely elucidated. Therefore, elucidating the functional roles of lncRNAs in chronic liver disease and HCC can contribute to a better understanding of the molecular mechanisms, and may help in developing novel diagnostic biomarkers and therapeutic targets for HCC, as well as in preventing the progression of chronic liver disease to HCC. Here, we comprehensively review and briefly summarize some lncRNAs that participate in both hepatic fibrosis and HCC.

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Long noncoding RNA PVT1 inhibits renal cancer cell apoptosis by up-regulating Mcl-1

Cited by 26 publications

References 30 publications

Retracted: Down‐regulation of long noncoding RNA PVT1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via microRNA‐145‐mediated inhibition of FSCN1

Retracted: Down‐regulation of long noncoding RNA PVT1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via microRNA‐145‐mediated inhibition of FSCN1

LncRNA NBAT1 suppresses cell proliferation and migration via miR‐346/GSK‐3β axis in renal carcinoma

LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

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