Long noncoding RNA lncKdm2b: A critical player in the maintenance of group 3 innate lymphoid cells

Guo, Can; Zhang, Weici; Gershwin, M. Eric

doi:10.1038/cmi.2017.55

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…lncRNAs have been demonstrated to be indispensable during the development of immune cells and in the regulation of the immune response. [8][9][10] Here, we review the known functional lncRNAs on a case-by-case basis to clarify their functions and the mechanisms through which they are involved in the metabolic regulation of inflammatory responses and immune disorders. lncRNAs in metabolic regulation during viral infection The immune system could hardly function without the proper regulation of metabolism for cytokine production, phagocytosis, and pathogen elimination.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNAs in the metabolic control of inflammation and immune disorders

Cao

2018

Cell Mol Immunol

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The metabolic control of immune cell development and function has been shown to be critical for the maintenance of immune homeostasis and is also involved in the pathogenesis of immune disorders. Pathogenic infections or cancers may induce metabolic reprogramming through different pathways to meet the energy and metabolite demands for pathogen propagation or cancer progression. In addition, some deregulated metabolites could trigger or regulate immune responses, thus causing chronic inflammation or immune disorders, such as viral infection, cancer and obesity. Therefore, the methods through which metabolism is regulated and the role of metabolic regulation in inflammation and immunity attract much attention. Epigenetic regulation of inflammation and immunity is an emerging field. Long noncoding RNAs (lncRNAs) have been well documented to play crucial roles in many biological processes through diverse mechanisms, including immune regulation and metabolic alternation. Here, we review the functions and mechanisms of lncRNAs in the metabolic regulation of inflammatory immune disorders, aiming to deepen our understanding of the epigenetic regulation of inflammation and immunity.

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Section: Introductionmentioning

confidence: 99%

Long noncoding RNAs in the metabolic control of inflammation and immune disorders

Cao

2018

Cell Mol Immunol

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“…In a similar fashion to recent studies in ILC1, noncoding elements of the genome have recently emerged as critical players in the regulation of ILC3 differentiation, function, and maintenance. In particular, recent evidence revealed that the lncRNA LncKdm2b is an essential regulator of ILC3 proliferation and functions 91,92 . Indeed, this lncRNA is highly expressed by ILC3 and disruption of its expression causes the decreased recruitment of the NURF chromatin‐remodeling complex in a Satb1‐dependent manner to key genes regulating ILC3 proliferation such as Zfp292 (encodes zinc finger protein 292) 92 .…”

Section: Heterogeneity and Chromatin Remodeling In Mature Ilcmentioning

confidence: 99%

Ontogeny and heterogeneity of innate lymphoid cells and the noncoding genome

Michieletto

Henao‐Mejia

2021

Immunological Reviews

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Since their discovery a decade ago, it has become evident that innate lymphoid cells (ILCs) play critical roles in protective immune responses against intracellular and extracellular pathogens but are also central regulators of epithelial barrier integrity and tissue homeostasis. ILCs populate almost every tissue in mammalian organisms; therefore, not surprisingly, dysregulation of their functions contributes to the development and progression of multiple inflammatory and metabolic diseases. Our knowledge of the transcriptional programs governing the development, differentiation, and functions of the different groups of ILCs has increased dramatically in the last ten years. However, with the advent of new technologies, an unprecedented level of heterogeneity, plasticity, and developmental complexity has started to be revealed. In this review, we highlight recent advances in our understanding of ILC development and their biological functions. In particular, we aim to emphasize how our increasing knowledge of the chromatin landscape and the noncoding genome of these innate lymphocytes is allowing us to better understand their development and functions in different contexts during homeostasis and inflammation. Moreover, we propose that the design of more refined genetic tools to study tissue‐specific ILCs and their functions can be accomplished by leveraging our understanding of how specific noncoding elements of the genome regulate gene expression in ILCs.

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“…Moreover, there are several studies suggesting that circRNAs, lncRNAs and miRNAs are epigenetic regulators with prognostic and therapeutic effects in digestive system tumors [9][10][11]. LncRNAs are defined as nonprotein-coding RNAs with lengths exceeding 200 nucleotides [12,13]. Recent studies on formation and functional mechanisms of lncRNAs have shown that lncRNAs play a key role in regulating chromatin dynamics, gene expression and maintaining biological processes [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

LncRNA HULC as a potential predictor of prognosis and clinicopathological features in patients with digestive system tumors: a meta-analysis

Wang

et al. 2022

Aging

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Objective: This meta-analysis aimed to evaluate the correlation between lncRNA HULC, prognosis and clinicopathological characteristics in patients with digestive system tumors. Methods: The relevant literatures were collected through PubMed, Web of Science and Embase up to February 2021. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to assess the prognostic value of HULC in patients with digestive system tumors. The clinicopathological characteristics of HULC in patients were estimated by odds ratios (ORs). Results: A total of 14 studies involving 1312 patients were included. The up-regulated expression level of HULC was associated with poorer overall survival (OS) in patients with digestive system tumors (HR = 1.83, 95% CI: 1.05-3.19, P = 0.033). Subgroup analysis showed that cancer type (pancreatic cancer or gastric cancer), residence region (China, Japan or Korea), and specimen (serum) significantly associated between HULC and OS. In addition, high HULC expression significantly increased the risk of high TNM stage (OR = 2.51, 95%CI: 1.36-4.62, P < 0.05), poor differentiation (OR = 1.38, 95%CI: 1.02-1.87, P < 0.05) and lymphatic node metastasis (LNM, OR = 4.93, 95% CI: 3.47-6.99, P < 0.05). Conclusions: High expression level of HULC is related to OS, TNM stage, differentiation and LNM. Therefore, HULC can be used as a new potential predictor for prognosis and clinicopathological features of patients with digestive system tumors.

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Long noncoding RNA lncKdm2b: A critical player in the maintenance of group 3 innate lymphoid cells

Cited by 6 publications

References 15 publications

Long noncoding RNAs in the metabolic control of inflammation and immune disorders

Long noncoding RNAs in the metabolic control of inflammation and immune disorders

Ontogeny and heterogeneity of innate lymphoid cells and the noncoding genome

LncRNA HULC as a potential predictor of prognosis and clinicopathological features in patients with digestive system tumors: a meta-analysis

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