2016
DOI: 10.1016/j.tranon.2016.09.005
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Abstract: Recent studies have shown that long noncoding RNAs (lncRNAs) play pivotal roles in the initiation and progression of cancer, including esophageal squamous cell carcinoma (ESCC). The lncRNA HOX transcript antisense RNA (HOTAIR) was reported to be dysregulated and correlated with the progression of ESCC. However, the biological role and the underlying mechanism of HOTAIR in the development of ESCC remain unclear. Herein, we found that HOTAIR was aberrantly upregulated in ESCC cells and that HOTAIR depletion inhi… Show more

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Cited by 64 publications
(51 citation statements)
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“…The lncRNA‐miRNA‐mRNA regulatory network and the ceRNA mechanisms have been extensively confirmed in many reports, in which lncRNA competitively sponges miRNAs at post‐transcriptional level, thus leading to derepression of miRNA target genes . Based on the previous researches, we speculated that LINC00511 may also participate in the regulatory network of TSCC progression and own potential interactions with related miRNA.…”
Section: Discussionmentioning
confidence: 65%
“…The lncRNA‐miRNA‐mRNA regulatory network and the ceRNA mechanisms have been extensively confirmed in many reports, in which lncRNA competitively sponges miRNAs at post‐transcriptional level, thus leading to derepression of miRNA target genes . Based on the previous researches, we speculated that LINC00511 may also participate in the regulatory network of TSCC progression and own potential interactions with related miRNA.…”
Section: Discussionmentioning
confidence: 65%
“…LncRNA HOTAIR resides at the HOXC locus and has been reported to be upregulated in many types of cancers [24][25][26][27][28][29]. For instance, Xia et al reported that HOTAIR can promote metastasis in renal cell carcinoma by upregulating the histone demethylase JMJD3 [30].…”
Section: Discussionmentioning
confidence: 99%
“…Compared with the conventional clinical tumor markers, the combined assessment of the expression of the lncRNAs ADAMTS9‐AS1 and AP000696.2 was a better predictor of ESCC prognosis . The lncRNA HOTAIR has been reported to regulate the ESCC cell cycle . Mechanistically, the lncRNA HOTTIP promotes ESCC transfer and EMT progression .…”
Section: Discussionmentioning
confidence: 99%
“…22 The lncRNA HOTAIR has been reported to regulate the ESCC cell cycle. 23 Mechanistically, the lncRNA HOTTIP promotes ESCC transfer and EMT progression. 24 LncRNA SPRY4-IT1 promotes ESCC cell survival by activating the expression of zinc finger 703 and related proteins.…”
Section: Discussionmentioning
confidence: 99%