Long Non-Coding RNAs Involved in Gynecological Cancer

Zhao, Mingjun; Qiu, Yiran; Yang, Baohong; Lee, Sun; Hei, Kaiwen; Du, Xue; Li, Yongmei

doi:10.1097/igc.0000000000000212

Cited by 36 publications

(21 citation statements)

References 46 publications

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“…It should be noted that this study was limited by its retrospective nature; however, a large number of cases were examined along with long term survival data. Many studies have shown that lncRNA acts as an unfavorable prognostic factor in various human cancers [17,18,29]; thus, the clinical and prognostic significance of HOXA11as were identified in this study. Moreover, only serous type histology was investigated to overcome the heterogeneity of the study population.…”

Section: Discussionmentioning

confidence: 94%

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Long Non-coding RNA HOXA11 Antisense Promotes Cell Proliferation and Invasion and Predicts Patient Prognosis in Serous Ovarian Cancer

Yim

Kim

et al. 2017

Cancer Res Treat

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PurposeThe biological function of long non-coding RNAs (lncRNAs) is only partially understood; therefore, in this study, we investigated the expression of the novel HOXA11 antisense (HOXA11as) lncRNA and its oncogenic role in serous ovarian cancer (SOC).Materials and MethodsHOXA11as expression was examined in 129 SOC tissue samples by real time reverse transcription polymerase chain reaction. Clinicopathological factors and patient survival were compared between the high (n=27) and low HOXA11as expression group (n=102). To investigate the role of HOXA11as in cell proliferation, invasion, and migration, HOXA11as expression in ovarian cancer cells was knocked down using RNA interference.ResultsHOXA11as expression in cancer tissue was 77-fold higher than that of noncancerous tissue (p < 0.05). Higher HOXA11as expression was significantly correlated with histological grade (p=0.017) and preoperative cancer antigen 125 (p=0.048). HOXA11as overexpression in SOC cells led to increased cell proliferation, invasion, and migration. Moreover, HOXA11as was associated with the expression of genes involved in cell invasion, migration, and epithelial-mesenchymal transition (EMT), including vascular endothelial growth factor, matrix metalloproteinase 9 (MMP-9), B-catenin, E-cadherin, Snail, Twist, and vimentin. Multivariate analysis revealed that HOXA11as was a prognostic factor of progressive disease and mortality (hazard ratio [HR], 1.730; p=0.043 and HR, 2.170; p=0.033, respectively). Progression-free and overall survival were significantly shorter in patients with high HOXA11as expression.ConclusionThese findings highlight the clinical significance of HOXA11as to predicting the prognosis of SOC patients and suggest its potential in promoting tumor aggressiveness via regulation of vascular endothelial growth factor (VEGF), MMP-9, and EMT-related mechanisms.

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Section: Discussionmentioning

confidence: 94%

“…Several lncRNAs have been identified in gynecological cancer, including HOTAIR , MALAT-1 , H19 , and LSINCT5 [17]. One of the most popular oncogenic lncRNA studied is HOX transcript antisense intergenic RNA ( HOTAIR ), which our group recently identified as playing a role in cell proliferation and invasion in cervical cancer cell lines [18].…”

Section: Discussionmentioning

confidence: 99%

Long Non-coding RNA HOXA11 Antisense Promotes Cell Proliferation and Invasion and Predicts Patient Prognosis in Serous Ovarian Cancer

Yim

Kim

et al. 2017

Cancer Res Treat

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“…Interestingly, its expression is induced by carboplatin, thus raising the sensitivity of ovarian cancer cells to this drug [121]. More studies are needed to elucidate its role in modulating sensitivity to cisplatin and its modes of regulation, which could lead to new ways of predicting and/or modulating the clinical response to this drug [122]. …”

Section: Lncrnas With a Role In Ovarian Cancermentioning

confidence: 99%

Dysregulated expression of long noncoding RNAs in gynecologic cancers

et al. 2017

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Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed to play a crucial role in several different biological processes, has made the regulation of gene expression more complex. Although the function of lncRNAs is still rather elusive, their broad involvement in the initiation and progression of various cancers is clear. They are also involved in the pathogenesis of cancers of the female reproductive system. LncRNAs play a critical physiological role in apoptosis, metastasis, invasion, migration and cell proliferation in these cancers. Different expression profiles of lncRNAs have been observed in various types of tumors compared with normal tissues and between malignant and benign tumors. These differential expression patterns may lead to the promotion or suppression of cancer development and tumorigenesis. In the current review, we present the lncRNAs that show a differential expression between cancerous and normal tissues in ovarian, cervical and endometrial cancers, and highlight the associations between lncRNAs and some of the molecular pathways involved in these cancers.

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“…Ovarian cancer is a common gynecological malignant tumor, as well as one of the most lethal gynecological malignancies in the world . Despite improvements in surgery, radiotherapy and neoadjuvant chemotherapy as the main methods to treat ovarian cancer, the 5‐year survival rate of patients is still only 30% . The lack of biomarkers for early detection and diagnosis is the major cause of the low survival rate.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA LINC00152 promotes cell proliferation through competitively binding endogenous miR‐125b with MCL‐1 by regulating mitochondrial apoptosis pathways in ovarian cancer

et al. 2018

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Recently, an increasing number of studies have focused on the key function of long noncoding RNAs (lncRNAs) in biological activity. Abnormal lncRNA expression was found to relate to the development and pathogenesis of multiple cancers. LncRNA LINC00152 served as an oncogene in multiple cancers; however, its role in ovarian cancer remains unknown. In our research study, LINC00152 was upregulated in ovarian cancer tissues and cell lines. An increasing LINC00152 level was positively correlated with the histological grade, clinical stage, and poor prognosis of ovarian cancer patients. In addition, knockdown of LINC00152 reduced cell growth, induced cell apoptosis, and suppressed tumor growth. Moreover, we revealed that LINC00152 and Myeloid cell leukemia‐1 (MCL‐1) were targeted by miR‐125b and had the same miR‐125b combining site. The miR‐125b level was negatively correlated with the expression of LINC00152, while MCL‐1 was positively related to the LINC00152 level. MiR‐125b could affect LINC00152 levels as evaluated by qRT‐PCR. Finally, we affirmed that LINC00152 mediated cell proliferation by affecting MCL‐1 expression and MCL‐1‐mediated mitochondrial apoptosis pathways and by working as a competitive endogenous RNA (ceRNA) of miR‐125b. In summary, based on ceRNA theory, the combined research on miR‐125b and MCL‐1, and taking LINC00152 as a new study point, we provide new insight into the molecular mechanism of reversing cell proliferation in ovarian cancer.

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Long Non-Coding RNAs Involved in Gynecological Cancer

Cited by 36 publications

References 46 publications

Long Non-coding RNA HOXA11 Antisense Promotes Cell Proliferation and Invasion and Predicts Patient Prognosis in Serous Ovarian Cancer

Long Non-coding RNA HOXA11 Antisense Promotes Cell Proliferation and Invasion and Predicts Patient Prognosis in Serous Ovarian Cancer

Dysregulated expression of long noncoding RNAs in gynecologic cancers

Long noncoding RNA LINC00152 promotes cell proliferation through competitively binding endogenous miR‐125b with MCL‐1 by regulating mitochondrial apoptosis pathways in ovarian cancer

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