Long non-coding RNA XLOC_008466 acts as an oncogenic molecular in cervical cancer tumorigenesis

Guo, Fang; Chen, Yunzhi; Li, Liu; Chen, Cong; Jen, Jin; Yang, Ju Hye; Chen, Jingjing; Chen, Xinyan; Guo, Min; Chen, Yumei

doi:10.1016/j.biopha.2017.11.143

Cited by 14 publications

(7 citation statements)

References 26 publications

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“…Regarding to miR-216b, it is implicated to hamper tumors and its under-expression may relate to cancer biology [ 39 ]. Of importance, knocking down lncRNA XLOC_008466 is witnessed to retard proliferation, invasion and migration, as well as drive apoptosis through enhancing miR-216b in CC [ 40 ]. Announced in an innovative research, miR-216b expression is reduced and forced expression of miR-216b achieves to destruct cell viability, migration, invasion whereas aggravate apoptosis in EC [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer

Zhang

Zhao

et al. 2022

Nanoscale Res Lett

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Objective LINC01354 has been defined as a tumor driver in several cancers. Nevertheless, whether LINC01354 involves in endometrial cancer (EC) has been little navigated. Thus, the mechanism of LINC01354 was explored in the disease. Methods Measurements of LINC01354, microRNA (miR)-216b and kirsten rat sarcoma viral oncogene (KRAS) levels in EC tissues and cells were performed. LINC01354 low expression and miR-216b overexpression vectors were introduced into EC cells (lshikawa), thereby their effects on cell viability, apoptosis, migration and invasion were manifested. Rescue experiments were also carried out by down-regulating LINC01354 and miR-216b spontaneously. Tumorigenesis in vivo was also assessed. The relationships of LINC01354/miR-216b/KRAS were analyzed. Results Increased LINC01354 and KRAS and reduced miR-216b levels were measured in EC. Silencing LINC01354 or overexpressing miR-216b retarded EC cellular development. LINC01354 counteracted with miR-216b to target KRAS. Suppression of miR-216b antagonized silenced LINC01354-induced impacts on EC cell development. LINC01354/miR-216b/KRAS axis enhanced tumorigenesis in mice with EC. Conclusion It is testified that silencing LINC01354 inhibits KRAS by up-regulating miR-216b, thereby discouraging cell malignant phenotype in EC.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer

Zhang

Zhao

et al. 2022

Nanoscale Res Lett

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“…Several important lncRNAs have been identified in CC, such as SNHG20 and XLOC_008466. 18,19 Thus, it is still critical to reveal the correlation between lncRNA and CC progression in depth.…”

Section: Introductionmentioning

confidence: 99%

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

Liu

Wen

2020

CMAR

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“…e overexpression of lncRNA-XLOC_006390 has been shown to be associated with several human cancers, and lncRNA-XLOC_00630 was proven to have oncogenic role in cancer tumorigenesis [14,17]. Further, it was previously shown that overexpression of lncRNA-XLOC_006390 marks the pathological advancement of human cancer and is linked with the disease metastasis [18]. Supporting the same, the results of our present study showed that the expression of lncRNA-XLOC_006390 increases with the progression of colorectal cancer and promotes the cancer metastasis which highlights the potency of lncRNA-XLOC_006390 to serve in the disease prognosis and therapeutic formulations.…”

Section: Discussionmentioning

confidence: 99%

Long Noncoding XLOC_006390 Regulates the Proliferation and Metastasis of Human Colorectal Cancer via miR-296/ONECUT2 Axis

Qiao

Huang

et al. 2022

Journal of Oncology

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Long noncoding RNA (LncRNA) XLOC_006390 has been shown to be dysregulated in cancer tissues and regulates cancer growth and development. Nonetheless, the molecular role of lncRNA-XLOC_006390 in colorectal cancer via modulation of miR-296/ONECUT2 axis is still unclear. Against this backdrop, the current study was designed to explore the role of lncRNA-XLOC_006390 in colorectal cancer proliferation and metastasis. The results revealed significant ( P < 0.05 ) overexpression of lncRNA-XLOC_006390 in colorectal cancer tissues and cell lines, and the transcript levels increased with the advancement of the disease. Moreover, its high expression was shown to be associated with poor patient survival. Silencing of lncRNA-XLOC_006390 in colorectal cancer cells significantly ( P < 0.05 ) suppressed their viability via onset of apoptosis and restricted cancer cell migration and invasion. In vivo tumor growth was significantly ( P < 0.05 ) inhibited under lncRNA-XLOC_006390 repression. LncRNA-XLOC_006390 was shown to sponge the expression of miR-296-3p which in turn acted via post-transcriptional suppression of ONECUT 2 transcription factor to regulate the growth of colorectal cancer. Taken together, the results revealed the oncogenic role of lncRNA-XLOC_006390 in colorectal cancer via modulation of miR-296/ONECUT2 axis. The results also point towards its prognostic and therapeutic potential in the treatment of colorectal cancer.

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Long non-coding RNA XLOC_008466 acts as an oncogenic molecular in cervical cancer tumorigenesis

Cited by 14 publications

References 26 publications

RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer

RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

Long Noncoding XLOC_006390 Regulates the Proliferation and Metastasis of Human Colorectal Cancer via miR-296/ONECUT2 Axis

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