Long non-coding RNA FAM83H-AS1 acts as a potential oncogenic driver in human ovarian cancer

Yuan, Xiaolei; Huang, Ying; Guo, Man; Hu, Xiaowei; Li, Peiling

doi:10.1186/s13048-020-00756-y

Cited by 4 publications

(1 citation statement)

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“…Moreover, studies have indicated that m6A modification of lncRNA MIR155HG promotes immune escape of hepatocellular carcinoma cells to upregulate PD-L1 expression [ 33 ]. Similarly, the methylation level of lncRNA FAM83H-AS1 was related to the gene expression of FAM83H-AS1, which was related to immune cell infiltration in OC patients [ 34 ]. These findings further inspired us to conclude that methylation modification of lncRNAs can modulate the immune microenvironment and thus modulate tumor cell biology characteristics.…”

Section: Introductionmentioning

confidence: 99%

A methylation- and immune-related lncRNA signature to predict ovarian cancer outcome and uncover mechanisms of chemoresistance

Chen,

Gao,

Lin

et al. 2023

J Ovarian Res

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Tumor-associated lncRNAs regulated by epigenetic modification switches mediate immune escape and chemoresistance in ovarian cancer (OC). However, the underlying mechanisms and concrete targets have not been systematically elucidated. Here, we discovered that methylation modifications played a significant role in regulating immune cell infiltration and sensitizing OC to chemotherapy by modulating immune-related lncRNAs (irlncRNAs), which represent tumor immune status. Through deep analysis of the TCGA database, a prognostic risk model incorporating four methylation-related lncRNAs (mrlncRNAs) and irlncRNAs was constructed. Twenty-one mrlncRNA/irlncRNA pairs were identified that were significantly related to the overall survival (OS) of OC patients. Subsequently, we selected four lncRNAs to construct a risk signature predictive of OS and indicative of OC immune infiltration, and verified the robustness of the risk signature in an internal validation set. The risk score was an independent prognostic factor for OC prognosis, which was demonstrated via multifactorial Cox regression analysis and nomogram. Moreover, risk scores were negatively related to the expression of CD274, CTLA4, ICOS, LAG3, PDCD1, and PDCD1LG2 and negatively correlated with CD8+, CD4+, and Treg tumor-infiltrating immune cells. In addition, a high-risk score was associated with a higher IC50 value for cisplatin, which was associated with a significantly worse clinical outcome. Next, a competing endogenous RNA (ceRNA) network and a signaling pathway controlling the infiltration of CD8+ T cells were explored based on the lncRNA model, which suggested a potential therapeutic target for immunotherapy. Overall, this study constructed a prognostic model by pairing mrlncRNAs and irlncRNAs and revealed the critical role of the FTO/RP5-991G20.1/hsa-miR-1976/MEIS1 signaling pathway in regulating immune function and enhancing anticancer therapy.

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Section: Introductionmentioning

confidence: 99%