Long non-coding RNA CCAT2 drives the growth of laryngeal squamous cell carcinoma via regulating YAP activity

Zang, Yanzi; Li, Jing; Wan, Baoluo; Tai, Yu‐Tzu; Liu, Hongjian; Li, Qian; Ji, Yuzi

doi:10.1007/s13577-021-00606-z

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…A recent study by Zang et al investigated the mechanisms by which CCAT2 promotes cellular proliferation and showed that it directly binds to YAP protein and inhibits its phosphorylation, which further promotes YAP nuclear translocation and activation of YAP's downstream oncogenic targets CTGF, CYR62, and AMOTL2 [132].…”

Section: Ccat2 Enhancer Activity and Interactions With Rbpsmentioning

confidence: 99%

The Roles of the Colon Cancer Associated Transcript 2 (CCAT2) Long Non-Coding RNA in Cancer: A Comprehensive Characterization of the Tumorigenic and Molecular Functions

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Drula

Nuțu

et al. 2021

IJMS

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Colon cancer-associated transcript 2 (CCAT2) is an intensively studied lncRNA with important regulatory roles in cancer. As such, cumulative studies indicate that CCAT2 displays a high functional versatility due to its direct interaction with multiple RNA binding proteins, transcription factors, and other species of non-coding RNA, especially microRNA. The definitory mechanisms of CCAT2 are its role as a regulator of the TCF7L2 transcription factor, enhancer of MYC expression, and activator of the WNT/β-catenin pathway, as well as a role in promoting and maintaining chromosome instability through the BOP1–AURKB pathway. Additionally, we highlight how the encompassing rs6983267 SNP has been shown to confer CCAT2 with allele-specific functional and structural particularities, such as the allelic-specific reprogramming of glutamine metabolism. Additionally, we emphasize CCAT2’s role as a competitive endogenous RNA (ceRNA) for multiple tumor suppressor miRNAs, such as miR-4496, miR-493, miR-424, miR-216b, miR-23b, miR-34a, miR-145, miR-200b, and miR-143 and the pro-tumorigenic role of the altered regulatory axis. Additionally, due to its upregulation in tumor tissues, wide distribution across cancer types, and presence in serum samples, we outline CCAT2’s potential as a biomarker and disease indicator and its implications for the development of resistance against current cancer therapy regiments and metastasis.

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Section: Ccat2 Enhancer Activity and Interactions With Rbpsmentioning

confidence: 99%