2015
DOI: 10.1111/acel.12427
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: SummaryAging constitutes the key risk factor for age‐related diseases such as cancer and cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are complex phenotypes influenced by both environmental and genetic factors. The fact that genetic contribution to lifespan strongly increases with greater age provides basis for research on which “protective genes” are carried by long‐lived individuals. Studies have consistently revealed FOXO (Forkhead box O) transcription factors as importa… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

5
398
1

Year Published

2016
2016
2023
2023

Publication Types

Select...
8
2

Relationship

0
10

Authors

Journals

citations
Cited by 530 publications
(404 citation statements)
references
References 176 publications
5
398
1
Order By: Relevance
“…FoxO proteins have been shown to upregulate cell cycle inhibitors (Martins et al, 2015). In mice lacking one copy of the insulin receptor in all tissues, beta cell proliferation is reduced compared with that in wild-type mice, but deletion of one copy of Foxo1 partially rescues beta cell division (Nakae et al, 2002).…”
Section: Regulation Of Metabolism By Foxo1mentioning
confidence: 99%
“…FoxO proteins have been shown to upregulate cell cycle inhibitors (Martins et al, 2015). In mice lacking one copy of the insulin receptor in all tissues, beta cell proliferation is reduced compared with that in wild-type mice, but deletion of one copy of Foxo1 partially rescues beta cell division (Nakae et al, 2002).…”
Section: Regulation Of Metabolism By Foxo1mentioning
confidence: 99%
“…This indirect effect of hyperinsulinemia on carcinogenesis is mediated by the action of insulin (Ungefroren et al, 2015), which is known to signal through the PI3K-AKT axis and its downstream transcription network (Dormond et al, 2007;Wang et al, 2012;Gerber et al, 1998). Insulin triggers an intracellular pathway mediated by PI3K-AKT, allowing phosphorylation of FOXO factors which leads to its nuclear exclusion and, thereby suppression of FOXO-dependent transcription of target genes (Martins et al, 2016). In addition, AKT-dependent phosphorylation is also required as a prerequisite for ubiquitin-mediated degradation of FOXO3 (Ponugoti et al, 2012).…”
Section: Insulin Signallingmentioning
confidence: 99%
“…FOXO proteins are family of transcription factors that have important functions in development, aging, and longevity (Kahn, 2015; Martins, Lithgow, & Link, 2016). FOXO1, FOXO3, and FOXO4 are ubiquitously expressed, whereas FOXO6 expression is mainly detected in the brain (Eijkelenboom & Burgering, 2013).…”
Section: Introductionmentioning
confidence: 99%