2017
DOI: 10.18632/aging.101171
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Abstract: The expression of long non-coding RNAs (lncRNAs) is dysregulated in non-small cell lung cancer (NSCLC). However, the functions and contributions of lncRNAs remain largely unknown. Here, we identified a critical role of long intergenic non-protein coding RNA 00858 (LINC00858) in NSCLC. Ectopic expression of LINC00858 in NSCLC cells promoted cell proliferation and induced cell migration and invasion. Moreover, LINC00858 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-422a … Show more

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Cited by 46 publications
(33 citation statements)
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References 36 publications
(40 reference statements)
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“…6,[22][23][24][25] As we have mentioned that LOC100129148 promotes nasopharyngeal carcinoma progression by targeting miR-539-5p, 9 lncRNA EWSAT1 promotes nasopharyngeal cancer development by targeting miR-326/-330-5p 10 and LncRNA 00858 acts as an ceRNA of miR-422a in non-samll cell lung cancer. 11 In this study, we notified that the expression level of microRNA-26a was negatively correlated with the expression level of DLX6-AS1 in RCC tissue samples. This result suggested that DLX6-AS1 may work as a ceRNA to sponge miR-26a in RCC cells.…”
Section: Discussionmentioning
confidence: 83%
See 1 more Smart Citation
“…6,[22][23][24][25] As we have mentioned that LOC100129148 promotes nasopharyngeal carcinoma progression by targeting miR-539-5p, 9 lncRNA EWSAT1 promotes nasopharyngeal cancer development by targeting miR-326/-330-5p 10 and LncRNA 00858 acts as an ceRNA of miR-422a in non-samll cell lung cancer. 11 In this study, we notified that the expression level of microRNA-26a was negatively correlated with the expression level of DLX6-AS1 in RCC tissue samples. This result suggested that DLX6-AS1 may work as a ceRNA to sponge miR-26a in RCC cells.…”
Section: Discussionmentioning
confidence: 83%
“…5 It has been wildly investigated that lncRNAs modulate many types of tumor progression. [6][7][8] For example, lncRNA LOC100129148 and EWSAT1 have been reported to act as oncogenic role in nasopharyngeal carcinoma, 9,10 lncRNA 00858 functions as a competing endogenous RNA for miR-422a to facilitate the cell growth in non-small cell lung cancer 11 and Increased expression of long-noncoding RNA ZFAS1 is associated with epithelial-mesenchymal transition of gastric cancer. 12 It also has been reported that high DLX6-AS1 expression levels were significantly associated with both histological differentiation and TNM stage of lung cancer.…”
Section: Introductionmentioning
confidence: 99%
“…LncRNA LINC00858 (LINC00858), a newly identified lncRNA, is locates in 10q23.1. Recently, the dysregulation of LINC00858 has been reported in two tumours, including osteosarcoma and lung cancer [19,20]. In addition, in these two tumours, LINC00858 played a positive regulator.…”
Section: Introductionmentioning
confidence: 98%
“…Increased LINC00858 expression was reported in non-small cell lung cancer, and its upregulation significantly enhanced non-small cell lung cancer cell proliferation, migration and invasion. Upregulated LINC00858 expression was identified to be closely linked to the progression of non-small cell lung cancer (21). Another study indicated that the expression level of LINC00858 in lung adenocarcinoma was 5.23 times that in normal lung tissues (22).…”
Section: Discussionmentioning
confidence: 99%