volume 9, issue 2, P475-486 2017
DOI: 10.18632/aging.101171
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Shao-Ping Zhu, Jun-Yu Wang, Xian-Guo Wang, Jin-Ping Zhao

Abstract: The expression of long non-coding RNAs (lncRNAs) is dysregulated in non-small cell lung cancer (NSCLC). However, the functions and contributions of lncRNAs remain largely unknown. Here, we identified a critical role of long intergenic non-protein coding RNA 00858 (LINC00858) in NSCLC. Ectopic expression of LINC00858 in NSCLC cells promoted cell proliferation and induced cell migration and invasion. Moreover, LINC00858 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-422a …

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