Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons

Integrated Three-Electrode Dual-Mode Detection Chip for Place Cell Analysis: Dopamine Facilitates the Role of Place Cells in Encoding Spatial Locations of Novel Environments and Rewards

“…The hippocampus is crucial for exploring novel environments, and such novelty triggers an increase in dopamine levels in the hippocampus, leading to memory consolidation . Exposure to new environments increases the firing rate of dopamine neurons . Our findings corroborate these perspectives.…”

“…36 Exposure to new environments increases the firing rate of dopamine neurons. 37 Our findings corroborate these perspectives.…”

Electrical stimulation of the ventral tegmental area restores consciousness from sevoflurane-, dexmedetomidine-, and fentanyl-induced unconsciousness in rats

“…The locus coeruleus and VTA have extensive reciprocal projections [ 30 – 32 ]. Chemogenetic inhibition of locus coeruleus neurons attenuates phasic VTA firing [ 33 ], and chemical lesions of the locus coeruleus attenuate release of dopamine in the nucleus accumbens [ 34 ]. Similarly, both intravenous dexmedetomidine and local injections of dexmedetomidine into the locus coeruleus in rats have been shown to decrease dopamine levels in the nucleus accumbens in a dose-dependent manner [ 35 , 36 ].…”