Locomotor damage and brain oxidative stress induced by lead exposure are attenuated by gallic acid treatment

Reckziegel, Patrícia; Dias, Verônica Tironi; Benvegnú, Dalila Moter; Boufleur, Nardeli; Barcelos, Raquel Cristine Silva; Segat, Hecson Jesser; Pase, Camila Simonetti; Santos, Carlos Honorato Schuch; Flores, Érico M.M.; Bürger, Marilise Escobar

doi:10.1016/j.toxlet.2011.03.006

Cited by 62 publications

(42 citation statements)

References 79 publications

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“…(14). Especially, tea is an important source of GA and contains up to 4.5 g/kg of fresh weight (15). GA has multiple biological activities such as antibacterial, antiviral, anti-inflammatory, antioxidant, antitumor (16), and reduces heart infarction incidence and oxidative liver damage (17).…”

Section: Introductionmentioning

confidence: 99%

“…GA has multiple biological activities such as antibacterial, antiviral, anti-inflammatory, antioxidant, antitumor (16), and reduces heart infarction incidence and oxidative liver damage (17). This polyphenol is even more effective than ascorbic acid to prevent lipid peroxidation (15). Also, it was reported that GA shows antihyperglycemic and antihyperlipidemic activities (18).…”

Section: Introductionmentioning

confidence: 99%

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Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

Abdel-Moneim

El‐Twab

Ashour

et al. 2016

IJB

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The goal of diabetes treatment is primarily to save life and alleviate symptoms and secondary to prevent long-term diabetic complications resulting from hyperglycemia. Thus, our present investigation was designed to evaluate the hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin (NA/STZ)-induced diabetic rats. Experimental type 2 diabetes was induced by a single intraperitoneal (i.p.) injection of STZ (65 mg/kg b.wt.), after 15 min of i.p. injection of NA (120 mg/kg b.wt.). Gallic acid and p-coumaric acid were orally administered to diabetic rats at a dose of 20, 40 mg/kg b.wt./day, respectively, for 6 weeks. Body weight, serum glucose, protein profile, liver function enzymes and kidney function indicators was assayed. Treatment with either gallic acid or p-coumaric acid significantly ameliorated the elevated levels of glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and uric acid. Both compounds were also found to restore total protein, albumin, and globulin as well as body weight of diabetic rats to near normal values. It can conclude that both gallic acid and p-coumaric acid have potent hypoglycemic and hepato-renal protective effects in diabetic rats. Therefore, our results suggest promising hypoglycemic agents that can attenuate the progression of diabetic hepatopathy and nephropathy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

Abdel-Moneim

El‐Twab

Ashour

et al. 2016

IJB

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“…1). Especially, tea is an important source of GA and contains up to 4.5 g/kg of fresh weight (Reckziegel et al 2011).…”

Section: Introductionmentioning

confidence: 99%

“…It received much attention because of its potent ability to scavenge ROS, such as superoxide anions, hydrogen peroxide, hydroxyl radicals and hypochlorous acid (Mansouri et al 2013). This polyphenol is even more effective than ascorbic acid to prevent lipid peroxidation (Reckziegel et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats

et al. 2014

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There is little information about the hepatoprotective effects of gallic acid against ischemiareperfusion (I/R) damage. Animals were subjected to I/R. Gallic acid at doses of 50 and 100 mg/kg body weight (bw) were injected as a single dose prior to ischemia. Liver tissue homogenates were used for the measurement of malondialdehyde (MDA), catalase (CAT) and glutathione peroxidase (GPx) levels. At the same time alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were assayed in serum samples and compared statistically. While the ALT, AST, LDH activities and MDA levels were significantly increased, CAT and GPx activities significantly decreased in only I/Rinduced control rats compared to normal control rats (P \ 0.05). Treatment with gallic acid at a dose of 100 mg/kg bw significantly decreased the ALT, AST, LDH activities and MDA levels, and markedly increased activities of CAT and GPx in tissue homogenates compared to I/R-induced rats with no treatment group (P \ 0.05). In oxidative stress generated by hepatic ischemia-reperfusion, gallic acid contributes partially an alteration in the delicate balance between the scavenging capacity of antioxidant defense systems and free radicals in favour of the antioxidant defense systems in the body.

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“…Results of many studies performed on numerous experimental models, on various experimental animals (rats, rabbits, calf), have confirmed the hypertensive effect of small doses of lead and explained various mechanisms of this action. These mechanisms result from lead action on the central and peripheral nervous system (Hoffer et al, 1987;Nehru & Sidhu 2001;Silbergeld 1992;Reckziegel et al, 2011), the vessel wall (Ding et al, 1998;Dursun et al, 2005), the reninangiotensin system (Rodriguez-Iturbe et al, 2005;Sharifi et al, 2004), the kallikrein system (Carmignani et al, 1999), metabolic processes (Skoczynska et al, 1993;Skoczynska et al, 2004), the generation of free radicals (Stohs & Bagchi 1995;Vaziri et al 2001;Vaziri & Sica 2004), and intracellular signalling pathways (Carmignani et al, 2000), leading to an increase in the vascular tone, and the peripheral vascular resistance (Fig. 1).…”

Section: The Dependence Of Circulatory System Changes On Body Lead Bumentioning

confidence: 99%

Low-Level Exposure to Lead as a Cardiovascular Risk Factor

Skoczyńska¹,

Skoczyńska²

2012

Cardiovascular Risk Factors

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Locomotor damage and brain oxidative stress induced by lead exposure are attenuated by gallic acid treatment

Cited by 62 publications

References 79 publications

Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats

Low-Level Exposure to Lead as a Cardiovascular Risk Factor

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