2017
DOI: 10.17576/mh.2017.1202.22
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Locked-in Syndrome Following a King Cobra (Ophiophagus hannah) Envenomation

Abstract: The incidence of envenoming from king cobra, Ophiophagus hannah in human is relatively rare. Its venom acts on the postsynaptic region of the neuromuscular junction causing descending flaccid paralysis. Locked-in syndrome is a clinical state of inability to provide motor response in a conscious patient. Many reported cases of locked-in syndrome following neurotoxic snake-bite mimics brain death. We report a case of a middle aged man who presented with progressive neurological deficit following a king cobra bit… Show more

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Cited by 1 publication
(3 citation statements)
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“…Table 1 summarizes the reported cases of King Cobra envenomation in humans, with details of the clinical manifestation and the use of antivenom (if any) for treatment. All cases exhibited local envenomation effects at varying degrees of severity, most were presented with noticeable signs of aggravating inflammation (pain and intensive swelling around the bite site, which could be extending to the entire bitten limb and adjacent body structures) [ 31 , 36 ]. In severe envenomation, tissue necrosis developed requiring surgical interventions and amputation [ 37 ].…”
Section: Clinical Cases Of King Cobra Envenomationmentioning
confidence: 99%
See 2 more Smart Citations
“…Table 1 summarizes the reported cases of King Cobra envenomation in humans, with details of the clinical manifestation and the use of antivenom (if any) for treatment. All cases exhibited local envenomation effects at varying degrees of severity, most were presented with noticeable signs of aggravating inflammation (pain and intensive swelling around the bite site, which could be extending to the entire bitten limb and adjacent body structures) [ 31 , 36 ]. In severe envenomation, tissue necrosis developed requiring surgical interventions and amputation [ 37 ].…”
Section: Clinical Cases Of King Cobra Envenomationmentioning
confidence: 99%
“…, dizziness, vertigo, nausea), accompanied with signs of neuromuscular paralysis such as ptosis, limb weakness, dysphagia, dysarthria and flaccid paralysis. Paralysis of respiratory muscle results in asphyxia and generalized hypoxia, with death ensues from multiorgan failure [ 26 , 27 , 31 , 36 , 38 ].…”
Section: Clinical Cases Of King Cobra Envenomationmentioning
confidence: 99%
See 1 more Smart Citation