Location, Location, Location: How Vascular Specialization Influences Hematopoietic Fates During Development

Heck, Adam M.; Ishida, Takashi; Hadland, Brandon

doi:10.3389/fcell.2020.602617

Cited by 11 publications

(10 citation statements)

References 207 publications

(257 reference statements)

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“…This is followed by a second wave of yolk sac hematopoiesis, termed pro-definitive or transient definitive hematopoiesis [ 2 , 7 , 13 ]. This coincides with the emergence of multipotent erythro-myeloid progenitors (EMP) from hemogenic endothelium (HE) at approximately E8–8.5 [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ]. Between E9.5–10.5, these EMPs seed the fetal liver, where they generate myeloid cells, including erythroid cells, macrophages and granulocytes, and potentially low numbers of innate immune cells [ 2 , 7 , 13 , 40 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ].…”

Section: The Concept Of a Layered Hematopoietic Systemmentioning

confidence: 83%

“…The third wave of murine hematopoiesis originates in the AGM region of the embryo proper, with immature or pro-HSCs emerging from distinct HE before maturing into definitive long-term repopulating (LT) HSCs (via type I and II pre-HSC) by around E11.5 [ 2 , 13 , 46 , 47 , 49 , 51 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ]. HSC activity has additionally been found in the murine vitelline and umbilical arteries, embryonic head, heart and placenta [ 2 , 13 , 40 , 49 , 57 , 58 , 60 , 61 , 67 , 68 , 69 ].…”

Section: The Concept Of a Layered Hematopoietic Systemmentioning

confidence: 99%

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Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging

Watt

Hua

Roberts

2022

IJMS

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The past five decades have seen significant progress in our understanding of human hematopoiesis. This has in part been due to the unprecedented development of advanced technologies, which have allowed the identification and characterization of rare subsets of human hematopoietic stem and progenitor cells and their lineage trajectories from embryonic through to adult life. Additionally, surrogate in vitro and in vivo models, although not fully recapitulating human hematopoiesis, have spurred on these scientific advances. These approaches have heightened our knowledge of hematological disorders and diseases and have led to their improved diagnosis and therapies. Here, we review human hematopoiesis at each end of the age spectrum, during embryonic and fetal development and on aging, providing exemplars of recent progress in deciphering the increasingly complex cellular and molecular hematopoietic landscapes in health and disease. This review concludes by highlighting links between chronic inflammation and metabolic and epigenetic changes associated with aging and in the development of clonal hematopoiesis.

show abstract

Section: The Concept Of a Layered Hematopoietic Systemmentioning

confidence: 83%

Section: The Concept Of a Layered Hematopoietic Systemmentioning

confidence: 99%

Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging

Watt

Hua

Roberts

2022

IJMS

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“…Niche interactions are another critical component of driving EHT 4,78 . Induction of key developmental pathways via secreted ligands is spatially organized within the AGM and influence the potency of resultant progenitors 20 .…”

Section: Discussionmentioning

confidence: 99%

De-Novo Hematopoiesis From the Fetal Lung

Yeung

Villacorta‐Martin

Lindstrom-Vautrin

et al. 2022

Preprint

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Hemogenic endothelial cells (HECs) are specialized cells that undergo endothelial to hematopoietic transition (EHT) to give rise to hematopoietic progenitors. Though not defined as a hematopoietic organ, the lung houses many resident hematopoietic cells, aids in platelet biogenesis, and is a reservoir for hematopoietic stem and progenitor cells (HSPCs), but lung HECs have never been described. Using explant cultures of murine and human fetal lungs, we demonstrate that the fetal lung is a source of HECs that have the functional capacity to undergo EHT to produce de-novo HSPCs. Flow cytometric and functional assessment of fetal lung explants showed the production of HSPCs that expressed key EHT and pre-HSPC markers. scRNA-Seq and small molecule modulation demonstrated that fetal lung EHT is reliant on canonical EHT signaling pathways. These findings suggest that functional HECs are present in the fetal lung, thus establishing this location as a potential extramedullary site of de-novo hematopoiesis.

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“…Hematopoiesis is differentially regulated during development and intimately related to niche specialized endothelial cells in its infancy. Heck et al provide a comprehensively review of the current evidence on embryonic hematopoiesis and discuss the role of specialized vascular beds in the generation and expansion of hematopoietic stem and progenitor cells (Heck et al, 2020). Studies in different model organisms including the mouse, zebrafish and chicken as well as in human cells are discussed and contribute to a complementary understanding of embryonic hematopoietic development.…”

Section: Vascular Developmental Chaperon Of Hematopoiesis: From Embry...mentioning

confidence: 99%

Editorial: The Dynamic Interface Between Vascular Blood Vessels to Blood Forming Hematopoietic Stem Cells in Health and Disease

Itkin

Duarte

Passaro

2022

Front. Cell Dev. Biol.

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Location, Location, Location: How Vascular Specialization Influences Hematopoietic Fates During Development

Cited by 11 publications

References 207 publications

Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging

Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging

De-Novo Hematopoiesis From the Fetal Lung

Editorial: The Dynamic Interface Between Vascular Blood Vessels to Blood Forming Hematopoietic Stem Cells in Health and Disease

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