Localized prostate cancer

Kapoor, Anil; Hotte, Sébastien J.

doi:10.5489/cuaj.4054

Cited by 4 publications

(7 citation statements)

References 7 publications

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“…Prostate cancer (PCa) continues to plague male health around the world, representing the most common malignant tumor among male patients, accompanied by the second highest mortality rate in male patients with malignant tumors 1–3. Studies have revealed that, in 2016, 180,890 male patients in the USA were diagnosed with PCa, and another 85,920 patients succumbed to PCa 4.…”

Section: Introductionmentioning

confidence: 99%

<p>Overexpression of shugoshin1 predicts a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial–mesenchymal transition</p>

Mu¹,

Fan²,

Liu³

et al. 2019

OTT

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The aim of the study was to investigate the role of shugoshinl (SGO1) in human prostate cancer (PCa). Materials and methods: Quantitative real-time PCR (qRT-PCR) was used to determine the expression of SGO1 in PCa tissues and cell lines. The correlation between SGO1 expression and clinicopathological characteristics of PCa patients was analyzed using Kaplan-Meier analysis. SGO1 siRNA was successfully constructed and transfected into PCa cell lines (LNCaP and PC3). The knockdown efficacy was assessed by qRT-PCR. MTT assay and Transwell assay were conducted to observe the effect of SGO1 on the proliferation and invasion of PCa cell lines. Results: SGO1-expression levels were found to be higher in the PCa tissues and cell lines. Correlation was identified between the expression of SGO1 and preoperative prostate-specific antigen (P=0.017), lymph-node metastasis (P=0.044), and Gleason score (P=0.041). Patients with higher SGO1 expression displayed more advanced clinicopathological characteristics in addition to a shorter biochemical recurrence-free survival time. Additionally, SGO1 knockdown resulted in the inhibition of PCa cell proliferation, migration, and invasion. Conclusion: Taken together, the findings of the current study present evidence suggesting that SGO1 could inhibit the growth and invasion of PCa cells, highlighting its potential as a novel therapeutic target for the treatment of PCa.

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Section: Introductionmentioning

confidence: 99%

<p>Overexpression of shugoshin1 predicts a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial–mesenchymal transition</p>

Mu¹,

Fan²,

Liu³

et al. 2019

OTT

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“…PCa is the leading cause of noncutaneous malignancy in US men and the second leading cause of cancer mortality in men . In 2016, it is estimated that 180 890 men will be diagnosed with PCa, and 26 120 will die of PCa .…”

Section: Discussionmentioning

confidence: 99%

“…Prostate cancer (PCa) represents the second most common cancer in males, with 128 cases per 100 000 men . An estimated 1.1 million new PCa cases and 307 000 PCa deaths occurred every year .…”

Section: Introductionmentioning

confidence: 99%

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The relationship between homeobox B7 expression and the clinical characteristics of patient with prostate cancer

Song

Liao

Cui

2018

J of Cellular Biochemistry

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Background The prognosis of patients with prostate cancer (PCa) remains poor. Methods GSE16560, GSE32448, GSE79957, GSE17951, and TCGA‐PRAD were reanalyzed to evaluate the expression of homeobox B7 (HOXB7) between PCa tissues and normal prostate tissues and to characterize the correlation between the expression of HOXB7 and the clinicopathological features of patients with PCa. Gene set enrichment analysis was conducted to investigate the mechanisms. Results HOXB7 was upregulated in PCa tissues (P = 0.0005). Both the univariate and multivariate analyses demonstrated that the expression of HOXB7 was correlated with the Gleason score and TNM staging of patients with PCa. The Gleason score and TNM staging were higher in the HOXB7 high expression group. The overall survival (hazard ratio [HR] = 0.632; 95% confidence interval [CI]: 0.4773‐0.8369; P = 0.0014) and progression‐free survival (HR = 0.544; 95% CI: 0.3157‐0.9373; P = 0.0283) favored patients with PCa in HOXB7 low expression group over those in HOXB7 high expression group. PCa samples in HOXB7 low expression group were enriched in gene sets associated with the epithelial mesenchymal transition, apical junction, angiogenesis, ultraviolet response, and hypoxia. Conclusions HOXB7 might be an independent prognostic factor of patients with PCa.

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“…Prostate cancer (PCa) is the second most commonly diagnosed cancer and the fifth leading cause of cancer death in men [1,2]. An estimated 1.1 million new PCa cases and 307 thousand PCa deaths occurred in 2012 worldwide [3].…”

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confidence: 99%

Clinical relevance of semaphorin-3F in patients with prostate cancer

2019

CIM

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Purpose: To identify prognosis predictors for patients with prostate cancer (PCa). Methods: Four independent PCa microarray datasets (GSE32448, GSE16560, GSE79957 and GSE17951) were reanalyzed to characterize the expression of semaphorin-3F (SEMA3F) gene between PCa patients and normal prostate tissues and the correlation between SEMA3F expression and the age, tumor/nodes/metastasis (TNM) staging, Gleason Grade Group, prostate-specific antigen level and overall survival of PCa patients. Gene set enrichment analysis was applied to investigate the potential relevant mechanisms regarding the expression of SEMA3F and the proliferation of PCa cells. Results: The level of SEMA3F was significantly higher in normal prostate tissues compared with that in PCa cells (P

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Localized prostate cancer

Abstract: N/A

Cited by 4 publications

References 7 publications

<p>Overexpression of shugoshin1 predicts a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial–mesenchymal transition</p>

<p>Overexpression of shugoshin1 predicts a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial–mesenchymal transition</p>

The relationship between homeobox B7 expression and the clinical characteristics of patient with prostate cancer

Clinical relevance of semaphorin-3F in patients with prostate cancer

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Localized prostate cancer

Abstract: N/A

Cited by 4 publications

References 7 publications

<p>Overexpression of shugoshin1 predicts a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial&ndash;mesenchymal transition</p>

<p>Overexpression of shugoshin1 predicts a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial&ndash;mesenchymal transition</p>

The relationship between homeobox B7 expression and the clinical characteristics of patient with prostate cancer

Clinical relevance of semaphorin-3F in patients with prostate cancer

Contact Info

Product

Resources

About

<p>Overexpression of shugoshin1 predicts a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial–mesenchymal transition</p>

<p>Overexpression of shugoshin1 predicts a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial–mesenchymal transition</p>