Localized Pemphigus Foliaceus Induced by Topical Imiquimod Treatment

Lin, Rick; Ladd, Dan J.; Powell, Doreatha Jean; Way, Bill V.

doi:10.1001/archderm.140.7.889

Cited by 48 publications

(24 citation statements)

References 6 publications

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“…6,7,12 Topical medications, such as imiquimod and nonsteroidal anti-inflammatory drugs, have been implicated in localized PF (Table 1). 4,5 In contrast, to other cases reported, our patient was younger, she denied application of any topical medications, and the lesions did not become disseminated. Despite the clinical impression of impetigo, the lack of response to appropriate antibiotic treatment and the persistence of the lesions prompted us to suspect an immunobullous disorder as the source of the secondarily impetiginized lesions.…”

Section: Clinical Casecontrasting

confidence: 87%

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Localized Pemphigus Foliaceus with Unilateral Facial Involvement

Miner

Nousari

Alonso‐Llamazares

2014

Actas Dermo-Sifiliográficas

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Pemphigus foliaceus is a superficial vesiculobullous disease that typically presents with widespread lesions. Localized presentations are less frequent, and they typically occur in middle-aged patients, following exposure to topical medications, and later on, become more disseminated. We present a case of a 19-year-old female with a localized presentation of pemphigus foliaceus unrelated to previous topical medications, that was a diagnostic and therapeutically challenging case. We also discuss the literature on localized cases, differences in presentations and responses to various treatment modalities. Pénfigo foliáceo; Localizado; Enfermedades ampollosasPénfigo foliáceo localizado con afectación facial unilateral Resumen El pénfigo foliáceo es una enfermedad vesículo-ampollosa superficial caracterizada por la aparición de lesiones generalizadas. Las presentaciones localizadas son menos frecuentes y suelen observarse en pacientes de mediana edad tras la exposición a medicamentos tópicos que posteriormente evolucionan a formas más diseminadas. Presentamos el caso de una mujer de 19 años de edad con pénfigo foliáceo localizado no asociado a medicamentos tópicos previos cuyo diagnóstico y tratamiento han supuesto un reto. También analizamos la literatura existente sobre los casos de pénfigo foliáceo localizado, las diferencias en las presentaciones clínicas y las respuestas a distintos tipos de tratamientos.

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Section: Clinical Casecontrasting

confidence: 87%

“…3 The pathogenesis of PF is not completely understood, but environmental exposure appears to be involved. 2,4,5 We present an interesting case of a young woman with a difficult-to-treat, localized form of PF that was unrelated to any known triggers. …”

Section: Introductionmentioning

confidence: 99%

Localized Pemphigus Foliaceus with Unilateral Facial Involvement

Miner

Nousari

Alonso‐Llamazares

2014

Actas Dermo-Sifiliográficas

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“…A certain number of LP cases that have developed on burns, electrocoagulation, or surgical scars, have been reported in the literature suggesting a Koebner‐like phenomenon 1 . Other authors incriminated handling of pesticides and chemicals 2 . Recently, two cases of localized contact pemphigus had been observed following the application of ketoprofene gel and imiquimod 2 …”

Section: Characteristics Of Our Patientsmentioning

confidence: 99%

Localized pemphigus: a report of three cases

et al. 2010

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“…The most common of those weird systemic side effects are influenza-like symptoms and headache. A review of the literature revealed lots of unusual adverse reactions related to the topical use of this drug, which are summarized in table 1[10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57]. …”

Section: Discussionmentioning

confidence: 99%

Acute Renal Failure Caused by Imiquimod 5% Cream in a Renal Transplant Patient: Review of the Literature on Side Effects of Imiquimod

Santos‐Juanes

Esteve²,

Mas-Vidal³

et al. 2011

Dermatology

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Imiquimod is an immunomodulator of the imidazoquinoline group which possesses antiviral and antitumour activities. Although its mechanism of action has not been entirely elucidated yet, imiquimod 5% cream has been shown to be an efficient, long-lasting and safe therapy for multiple actinic keratoses in non-immunosuppressed patients and in transplant recipients. We report the case of a 44-year-old patient with a third renal transplant who developed an acute tubular necrosis confirmed by renal biopsy after the use of imiquimod 5% cream. The result of a literature search revealed a wide variety of side effects attributable to the use of imiquimod.

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Localized Pemphigus Foliaceus Induced by Topical Imiquimod Treatment

Cited by 48 publications

References 6 publications

Localized Pemphigus Foliaceus with Unilateral Facial Involvement

Localized Pemphigus Foliaceus with Unilateral Facial Involvement

Localized pemphigus: a report of three cases

Acute Renal Failure Caused by Imiquimod 5% Cream in a Renal Transplant Patient: Review of the Literature on Side Effects of Imiquimod

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