Localized cutaneous reactions to granulocyte colony-stimulating factor

Granulomatous Dermatitis with Enlarged Histiocytes: A Characteristic Pattern of Granulocyte Colony-Stimulating Factor

“…They include local reactions at the site of injection, specific cutaneous disorders and nonspecific maculopapular eruptions. Localized reactions at the site of injection are characterized by urticarial wheals with edema although lichenoid reactions have also been described [8,9,10]. Development of neutrophilic dermatoses such as Sweet’s syndrome [11,12,13], pyoderma gangrenosum [14, 15], neutrophilic eccrine hidradenitis [16], leukocytoclastic vasculitis [17,18,19] and folliculitis [20] have occasionally been reported.…”

Erythema exsudativum multiforme induced by granulocyte colony-stimulating factor in an allogeneic peripheral blood stem cell donor

“…They have included pyoderma gangrenosum, folliculitis and vasculitis, in addition to local reactions at the site of injection. [6][7][8] However, the association between G-CSF and cutaneous reactions is usually difficult to assess in patients because those who receive G-CSF are likely to have complex illnesses and to take other medications. [8][9][10] However, if such reactions are observed in a healthy individual receiving G-CSF, such as a PBSC donor, they are most likely due to G-CSF and could be evaluated as its adverse effects.…”

Lichenoid Cutaneous Drug Reaction at Injection Sites of Granulocyte Colony-Stimulating Factor (Filgrastim)

“…Subcutaneous nodules infiltrated by leukaemic blast cells at the site of injection in a 54-year-old woman with acute myelomonocytic leukaemia have been described [11]. Samlaska and Noyes [12]presented a patient with erythematous oedematous plaques at three injection sites with pruritus. The clinical presentation was very similar to our case; however, the pathology was different: biopsy specimens were remarkable for focal acanthosis, focal parakeratosis, vacuolar alteration, spongiosis and intra-epidermal micro-abscesses composed of eosinophils.…”

“…The clinical presentation was very similar to our case; however, the pathology was different: biopsy specimens were remarkable for focal acanthosis, focal parakeratosis, vacuolar alteration, spongiosis and intra-epidermal micro-abscesses composed of eosinophils. The involved sites slowly resolved with local care and application of triamcinolone cream, while the patient continued to receive G-CSF without complications over the following 2 months [12]. …”