Localized Cutaneous Mastocytosis following Radioiodine Ablation Therapy: A Case Report and Review of Literature

Wangia, Michael; Tepedino, Kelly; Ramos‐Caro, Francisco A.; Russo, Jacqueline J; Glavin, Frederick L.

doi:10.4172/2155-9619.1000133

Cited by 1 publication

(2 citation statements)

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“…5 Interestingly, there are rare reports in the literature of localized CM after systemic adjuvant radioiodine ablation therapy for papillary thyroid carcinoma and SM after long-term treatment of polycythemia vera with radioactive phosphorus. 10,11 Studies have demonstrated that human mast cells show increased histamine, tryptase, and inflammatory cytokine expression, with degranulation, after ionizing radiation. 5 These mast cell mediators serve an integral role in downstream fibroblast inflammatory responses, leading to commonly recognized cutaneous radiation reactions.…”

Section: Discussionmentioning

confidence: 99%

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Radiotherapy-Associated Cutaneous Mastocytosis in a Patient With Breast Carcinoma. Case Report and Review of the Literature

Murphy

Valentini

Shaughnessy

2023

The American Journal of Dermatopathology

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Mast cell skin disease is rarely described after external beam radiation therapy in patients with breast carcinoma, with only 7 previous reports in the literature. Skin changes typically occur within (but are not limited to) the radiation field. We present a 64-year-old woman with postradiotherapy cutaneous mastocytosis on the left breast and adjacent chest wall. The clinical and laboratory findings in all reported patients, including the current case, are reviewed. No clear mechanism has been presented to explain disease pathogenesis; although, mast cell accumulation secondary to local mediators produced in response to radiation damage and/or koebnerization phenomenon have been proposed. Cutaneous/systemic mastocytosis is not widely recognized and may be underdiagnosed in the setting of postradiation for breast cancer. It is important for clinicians and pathologists to be aware of this diagnosis for patients presenting with rashes after radiotherapy.

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