“…Table 1 provides a summary of patients' profiles, cancer types, lesion characteristics, histology and immunopathology [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31]. …”
Background: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Objective: To review the literature on radiation therapy (RT)-associated BP. Methods: A review of the English language literature on patients who developed BP during and up to 10 years post RT was performed. Results: 29 patients were reported. 25 (86.2%) were women, 84% of whom had received RT for breast cancer. Three patients were male (10.3%). Gender was not mentioned in 1 (3.4%). 72% developed BP post RT; 28% developed BP while undergoing RT. BP was initially localized to irradiated sites in 25 patients and to non-irradiated sites in 2 patients. Two patients presented with generalized disease. Disease control was reported in 12 patients, partial remission in 7 and complete remission in 5. Conclusion: The clinical profile, response to therapy and clinical outcome may indicate that RT-associated BP may be a specific subset of BP with a relatively benign course.
“…Table 1 provides a summary of patients' profiles, cancer types, lesion characteristics, histology and immunopathology [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31]. …”
Background: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Objective: To review the literature on radiation therapy (RT)-associated BP. Methods: A review of the English language literature on patients who developed BP during and up to 10 years post RT was performed. Results: 29 patients were reported. 25 (86.2%) were women, 84% of whom had received RT for breast cancer. Three patients were male (10.3%). Gender was not mentioned in 1 (3.4%). 72% developed BP post RT; 28% developed BP while undergoing RT. BP was initially localized to irradiated sites in 25 patients and to non-irradiated sites in 2 patients. Two patients presented with generalized disease. Disease control was reported in 12 patients, partial remission in 7 and complete remission in 5. Conclusion: The clinical profile, response to therapy and clinical outcome may indicate that RT-associated BP may be a specific subset of BP with a relatively benign course.
“…A variety of dermatosis have been described in the radiation site like lichen planus, bullous pemphigoid, pemphigus, SJS, chronic graft-versus-host disease (GVHD), comedones, etc. [6667686970717273]…”
Section: Discussion and Review Of Literaturementioning
“Wolf's isotopic response” refers to the occurrence of a new dermatosis at the site of previously healed dermatosis. A number of factors including viral, neural, vascular, and immunologic factors have been implicated in the causation of this peculiar response but none has been proven conclusively. Here, we report a case where lichen planus developed at the site of dermatofibrosarcoma protruberans that had been previously treated with surgery and radiotherapy. We also put forth a hypothesis on the genesis of isotopic response considering the above mentioned factors.
“…There are numerous case reports on ABD and breast cancer including predominantly BP [20,[81][82][83][84][85] and PV [86,87] with well-documented BP-lesion induction with radiotherapy.…”
Section: Malignancies Associated With Abdmentioning
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