Localized Argyria

Buckley, William R.

doi:10.1001/archderm.1963.01590230039005

Cited by 49 publications

(17 citation statements)

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“…Medical case histories indicate that dermal exposure to silver or silver compounds for extended periods of time can lead to local skin discoloration similar in nature to the generalized pigmentation seen after repeated oral exposure. However, the amount of silver and the duration of time required to produce this effect cannot be established with the existing information (Buckley 1963;McMahon and Bergfeld 1983). Moreover, adverse effects such as argyria have not been associated with the use of silver sulphadiazine as a bactericidal agent (Fox et al 1969).…”

Section: Systemic Effectsmentioning

confidence: 99%

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A randomized controlled evaluation of absorption of silver with the use of silver alginate (Algidex) patches in very low birth weight (VLBW) infants with central lines

et al. 2009

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Section: Systemic Effectsmentioning

confidence: 99%

“…For example, silver thiosulfate penetrated the intact skin of a photochemical worker via the eccrine sweat glands and deposited in the dermis, leading to the development of localized argyria within 6 months of exposure (Buckley 1963). Silver compounds also are absorbed through the damaged skin of humans.…”

Section: Dermal Exposurementioning

confidence: 99%

A randomized controlled evaluation of absorption of silver with the use of silver alginate (Algidex) patches in very low birth weight (VLBW) infants with central lines

et al. 2009

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“…6 The most common route of exposure to silver thiosulfate in an occupational setting is through dermal contact. In a study done by Buckley,7 it was shown that silver thiosulfate penetrated the skin through the sweat glands and deposited in the dermis of a photochemical worker, which led to the development of localized argyria within 6 months of exposure. Argyria is the local or generalized impregnation of the mucous membranes, skin, and eyes with silver.…”

Section: Toxicity and Environmental Significancementioning

confidence: 99%

Comparison of Discharge Silver Concentrations from Electrolytic Plating and Metallic Replacement Silver Recovery Units

Harper

Siegel

2003

Journal of the Air & Waste Management Association

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Silver-based photographic X-ray film is made of solid crystals of silver chloride or silver bromide suspended in a gelatin and then coated on a film. During the X-ray developing process, the image is processed and the nonimage areas containing solid silver chloride or silver bromide crystals are removed in a solution called the fixer. There may be local environmental regulations that regulate the amount of silver discharged from a facility. To meet these regulations, many facilities have added silver recovery units to their processes. Two different types of recovery processes are in use in a large hospital and three clinics under study. All of the units were claimed by their respective manufacturers to be able to recover silver down to concentrations of 5 mg/L. This concentration would ensure that the building that houses each unit would meet the local county limit of 0.5 mg/L silver for total building silver discharge. The hypothesis for this research is that one system, newer and more expensive, consisting of so-called electrolytic plating units (EPUs) (which are followed by so-called metallic replacement units [MRUs] as a backup), will have better silver recovery than MRUs alone.A total of six units were sampled, three EPUs (in combination with MRUs) and three MRUs. The units were sampled once or twice a day for 10 days for a total of 17 samples from each. The samples then were analyzed by inductively coupled plasma spectroscopy, and an analysis of variance was performed on the results. The range for the electrolytic plating unit/metallic replacement unit combinations was 0.20 -99.9 mg/L (mean of 35.15 mg/L; median of 33.8 mg/L). The range for the MRUs alone was 7.2-1112 mg/L (mean of 565.5 mg/L; median of 720 mg/ L). Many individual results exceeded 5 mg/L, such that extensive dilution would be required to ensure the building effluent did not exceed 0.5 mg/L. It is suggested that the metallic replacement units be changed to EPUs (with metallic replacement backup units) because they had better silver recovery. Also, the EPU combinations need to be sampled regularly to ensure that their silver concentrations are at acceptable levels. INTRODUCTIONSilver is a valuable metal that is used in many applications, including batteries, dental material, jewelry, electrical components, and photographic film. Photographic materials accounted for 45% of the U.S. consumption of silver in 1986. 1 Silver-based photographic materials such as X-ray film are made of solid crystals of silver chloride or silver bromide that are suspended in gelatin and coated on a film for support. 2 For X-ray film, after the image is processed, the remaining image on the film is metallic silver, while the nonimage areas containing solid silver chloride or silver bromide crystals are removed as a soluble silver-thiosulfate complex in a solution called the fixer. It is assumed that approximately 60 -66% of the silver on the film is washed away into the photographic fixer, which can then be processed to recover the silver.For many businesse...

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“…Fat-soluble chemicals may pass this barrier once it is damaged or may pass through the appendageal sebaceous glands. Entrance through sweat ducts is minimal although silver can enter thus to cause argyria (Buckley, 1963).…”

Section: Epidermal Defencementioning

confidence: 99%

Industrial dermatitis

Hodgson

1966

Postgraduate Medical Journal

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Localized Argyria

Cited by 49 publications

References 0 publications

A randomized controlled evaluation of absorption of silver with the use of silver alginate (Algidex) patches in very low birth weight (VLBW) infants with central lines

A randomized controlled evaluation of absorption of silver with the use of silver alginate (Algidex) patches in very low birth weight (VLBW) infants with central lines

Comparison of Discharge Silver Concentrations from Electrolytic Plating and Metallic Replacement Silver Recovery Units

Industrial dermatitis

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