Archives of Otolaryngology - Head and Neck Surgery
 1990
DOI: 10.1001/archotol.1990.01870120053008
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Localized Antigen Challenge of the Nasal Mucosa

Brian K. Flowers
1
,
David Proud2,
Anne Kagey‐Sobotka3
et al.
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Cited by 7 publications

(2 citation statements)
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“…Additionally, one cannot challenge one nostril and monitor responses on the opposite side to evaluate neuronal contributions to the nasal response, such as the nasonasal reflex. To overcome these limitations, we modified an existing localized challenge technique (7) and used it to study the kinetics of histamine release and physiological changes during the early allergic reaction. The results clarify the role of histamine in the early allergic reaction and provide a framework for the evaluation of other mediators.…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Additionally, one cannot challenge one nostril and monitor responses on the opposite side to evaluate neuronal contributions to the nasal response, such as the nasonasal reflex. To overcome these limitations, we modified an existing localized challenge technique (7) and used it to study the kinetics of histamine release and physiological changes during the early allergic reaction. The results clarify the role of histamine in the early allergic reaction and provide a framework for the evaluation of other mediators.…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…It is attractive to sample tracheobronchial and nasal mucosal surface liquids because their composition reflects the airway condition in health and disease. A simple and therefore attractive technique is to use absorbing paper discs [1][2][3][4]. However, this technique has not been extensively validated.…”
Section: Introductionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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