Localized and disseminated pagetoid reticulosis. Diagnostic immunophenotypical findings

Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

“…However, more recent studies unequivocally establish a T-cell lineage for the atypical epidermotropic cells (4, 8, 9, 14 -17). Further subtyping reveals three different phenotypes for the large epidermotropic cells, namely a CD4-positive T-helper phenotype (4,(17)(18)(19), CD8-positive T-cytotoxic/suppressor phenotype (4 -6, 9), or a CD4/CD8 double-negative phenotype (6,8,14,20). The results of the current study are in keeping with the observations described in the literature.…”

“…The proliferation rate, as measured by staining with the monoclonal antibody Ki-67, is usually below 10% in patch and plaque lesions of MF (35). In contrast, several studies, including ours (see Table 3), demonstrated in excess of 30% Ki-67-positive cells in PR (6,8,9,36,37). Similarly, MF only rarely contains CD30 (Ki-1)-positive cells (38,39), whereas CD30 reactivity is variable in PR.…”

“…At least nine reported cases demonstrated lack of CD45RO staining (6,20,23). Conversely, at least four cases tested positive for CD45RO (18,19).…”

Classification and clinical features in 88 cases of equine cutaneous lymphoma

“…Pagetoid reticulosis is another CTCL variant observed in human beings and dogs and is characterized by a high degree of epitheliotropism in which neoplastic cells are predominately confined to the epidermis. 9 However, in CTCL cases evaluated in the current study, the numbers of neoplastic T cells present within the epidermis were relatively low (limited to nests and small aggregates) and did not exhibit the marked epitheliotropism characteristic of pagetoid reticulosis. Although cases diagnosed as CTCL in this study were exclusively associated with the epidermis, a nonepitheliotropic subtype cannot be ruled out based on a limited sample size.…”

Pagetoid reticulosis with CD30 positivity and cytotoxic/suppressor cells

“…CD30 immunoreactivity has been previously reported in PR, but only a few cases showed a predominance of these cells 5,6,8 Table 1. lists the reported cases of PR with marked CD30 immunoreactivity.…”