Localized and disseminated pagetoid reticulosis. Diagnostic immunophenotypical findings

Mielke, V.

doi:10.1001/archderm.125.3.402

Cited by 32 publications

(30 citation statements)

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“…However, more recent studies unequivocally establish a T-cell lineage for the atypical epidermotropic cells (4, 8, 9, 14 -17). Further subtyping reveals three different phenotypes for the large epidermotropic cells, namely a CD4-positive T-helper phenotype (4,(17)(18)(19), CD8-positive T-cytotoxic/suppressor phenotype (4 -6, 9), or a CD4/CD8 double-negative phenotype (6,8,14,20). The results of the current study are in keeping with the observations described in the literature.…”

Section: Discussionsupporting

confidence: 88%

“…The proliferation rate, as measured by staining with the monoclonal antibody Ki-67, is usually below 10% in patch and plaque lesions of MF (35). In contrast, several studies, including ours (see Table 3), demonstrated in excess of 30% Ki-67-positive cells in PR (6,8,9,36,37). Similarly, MF only rarely contains CD30 (Ki-1)-positive cells (38,39), whereas CD30 reactivity is variable in PR.…”

Section: Cd2mentioning

confidence: 51%

“…At least nine reported cases demonstrated lack of CD45RO staining (6,20,23). Conversely, at least four cases tested positive for CD45RO (18,19).…”

Section: Discussionmentioning

confidence: 95%

“…Similarly, MF only rarely contains CD30 (Ki-1)-positive cells (38,39), whereas CD30 reactivity is variable in PR. Occasional cases showed a high percentage (Ͼ50%) of CD30-positive tumor cells (6,9), but other studies that tested for CD30 in PR found no expression (8,36). In our study, three of seven cases of PR were strongly positive for CD30 (Ͼ50% of cells).…”

Section: Cd2mentioning

confidence: 93%

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Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

et al. 2000

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Pagetoid reticulosis (PR), also known as WoringerKolopp disease, is a form of cutaneous T-cell lymphoma that demonstrates striking epidermotropism on histologic examination. We present the histologic, immunologic, and molecular findings for seven patients who had PR. The patients ranged in age from 33 to 67 years. All patients presented with one or several thick plaques involving the distal extremities except for one patient, who presented with a tongue lesion.

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Section: Discussionsupporting

confidence: 88%

Section: Cd2mentioning

confidence: 51%

“…At least nine reported cases demonstrated lack of CD45RO staining (6,20,23). Conversely, at least four cases tested positive for CD45RO (18,19).…”

Section: Discussionmentioning

confidence: 95%

Section: Cd2mentioning

confidence: 93%

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Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

et al. 2000

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“…Generalized cases would currently likely be classified as aggressive epidermotropic CD8 ϩ CTCL, cutaneous gamma/delta-positive T-cell lymphoma, or tumor-stage MF. 2,25,72 Clinical features. Patients present with a solitary psoriasiform or hyperkeratotic patch or plaque, which is usually localized on the extremities, and is slowly progressive.…”

Section: Variants and Subtypes Of Mycosis Fungoidesmentioning

confidence: 99%

WHO-EORTC classification for cutaneous lymphomas

Willemze

Jaffe

Burg

et al. 2005

Blood

3,496

4,355

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T-Cell Non-Hodgkin’s Lymphomas

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Several types of T-cell non-Hodgkin's lymphomas are characterized by liver involvement, usually in the context of generalized lymphoma disease. The aggressive neoplasm, T-cell prolymphocytic leukemia, showing a proliferation of small-to medium-sized T cells, results in massive bone marrow infiltration and marrow failure but also infiltrates the lymph nodes, liver, and spleen. Hepatic infiltrates mostly involve portal tracts, causing hepatomegaly. Hepatic involvement is a common feature of T-cell large granular lymphocytic leukemia. Liver infiltration is also known for aggressive NK cell leukemia, a systemic proliferation of NK cells almost always associated with EBV infection. The liver may be densely infiltrated by large granular lymphocytes with azurophilic granules. The generalized neoplastic T-lymphocyte process, adult T-cell leukemia/lymphoma, is frequently complicated by focal t diffuse parenchymal or portal tract infiltration of the liver. Other T-cell neoplasms variably involving the liver comprise nasal-type extranodal NK/T-cell lymphoma, hepatosplenic T-cell lymphoma, mycosis fungoides, Sézary syndrome, and peripheral T-cell lymphomas. T-Cell Prolymphocytic Leukemia ICD-O Code 9834/3 T-Cell Large Granular Lymphocytic Leukemia ICD-O Code 9831/3 T-cell receptor genes are in germline configuration and, therefore cannot be employed for clonality assessment. A part of the cases reveal clonal del (6)(q21q25) and 11q deletion.

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Localized and disseminated pagetoid reticulosis. Diagnostic immunophenotypical findings

Cited by 32 publications

References 0 publications

Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

WHO-EORTC classification for cutaneous lymphomas

T-Cell Non-Hodgkin’s Lymphomas

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