Localised Ewing sarcoma/PNET of bone—prognostic factors and international data comparison

Jenkin, R. D. T.; Al-Fawaz, I.; Alshabanah, Mohamed; Allam, Ayman; Ayas, Mouhab; Khafaga, Yasser; Memon, Muhammad Ali; Rifai, Samira; Schultz, Henrik; Younge, Derek

doi:10.1002/mpo.10212

Cited by 29 publications

(26 citation statements)

References 23 publications

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“…These characteristics include age, primary tumor location and size, the presence or absence of metastases, the serum lactate dehydrogenase level, and the response to therapy (Bacci et al 2000;Catterill et al 2000;Obata et al 2007;Rodriguez-Galindo et al 2003;Sluga et al 2001). Although chemotherapeutic regimens and treatment strategies based on prognostic factors have been advanced, previous reports from developing countries indicate that similar results were not obtained in non-western population (Cardenas-Cardos et al 1999;Jenkin et al 2002;Villarroel et al 1997) Thus, previously reported prognostic factors may not have the same inXuence on clinical outcome in patients belonging to populations with a low incidence, even if developed countries.…”

Section: Introductionmentioning

confidence: 95%

Prediction of response and prognostic factors for Ewing family of tumors in a low incidence population

Yonemori

Yamaguchi

Kaneko

et al. 2007

J Cancer Res Clin Oncol

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Section: Introductionmentioning

confidence: 95%

Prediction of response and prognostic factors for Ewing family of tumors in a low incidence population

Yonemori

Yamaguchi

Kaneko

et al. 2007

J Cancer Res Clin Oncol

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“…Improvements in diagnosis and chemotherapy treatment of PNET have led to a prolonged survival [1]. This emphases the importance of facilitating operative reconstruction and enabling normal growth in these children post therapy.…”

Section: Discussionmentioning

confidence: 97%

The novel use of small intestinal submucosal matrix for chest wall reconstruction following Ewing’s tumour resection

Murphy

Corbally

2007

Pediatr Surg Int

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Chest wall reconstruction following major tumour resection remains a challenging problem in the paediatric population due to the need for growth and development following the repair. Synthetic non-biodegradable grafts and materials have led to asymmetrical growth and significant functional and cosmetic compromise. The ideal graft material should be biological non-immunogenic which enables natural healing and facilitates further growth. Ewing's sarcoma is an uncommon primitive neuroectodermal tumour which rarely occurs in the ribs. However, recent improvements in management have produced a significantly improved survival; increasing the importance of chest wall reconstruction. We prospectively assessed the utilisation of Surgisis (an acellular collagen matrix) as a replacement graft in two children undergoing primary chest wall reconstruction following tumour resection. Surgisis is derived from porcine small intestinal submucosa (SIS) that serves as a template for tissue reconstruction and remodeling. The graft was well tolerated; there was no herniation and it allowed normal symmetrical chest movement and growth to occur. The properties of SIS allows natural collagen growth and compares favourably with marlex mesh and other forms of chest wall reconstruction. We believe its unique properties allow it to act as a suitable framework for chest wall reconstruction allowing chest wall growth and development.

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“…Prognosis of ET remains poor, with 5-year relapse-free survival of 55 to 65% in patients with localised disease and not exceeding 25% in primary metastatic disease. Survival at 5 years after relapse is less than 20% (Cotterill et al, 2000;Paulussen et al, 2001;Jenkin et al, 2002).…”

mentioning

confidence: 97%

“…In ET, prognostic factors include age, primary site, and tumour volume, the presence of metastases at diagnosis detected by conventional methods and histological response to induction chemotherapy (Cotterill et al, 2000;Paulussen et al, 2001;Jenkin et al, 2002). Bone marrow micrometastases and circulating tumour cells detected by RT -PCR were also recently reported as prognostic factors (Schleiermacher et al, 2003).…”

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confidence: 99%

Incidence and prognostic value of tumour cells detected by RT–PCR in peripheral blood stem cell collections from patients with Ewing tumour

et al. 2006

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To retrospectively evaluate the incidence of tumour cell contamination of peripheral blood stem cell (PBSC) collections and to correlate these data with the clinical outcome after high-dose chemotherapy (HDCT) with stem cell rescue in patients with a highrisk Ewing tumour. Peripheral blood stem cell collections obtained from 171 patients were analysed. Tumour contamination was assessed by reverse transcriptase -polymerase chain reaction (RT -PCR). The files of 88 patients who underwent HDCT followed by PBSC reinfusion were reviewed in detail, and their outcome compared to the PBSC RT -PCR results. Seven of 88 PBSC collections (8%) contained tumour cells as detected by RT -PCR. Peripheral blood stem cells were collected after a median of five cycles of chemotherapy. No clinical factor predictive of tumour cell contamination of PBSC harvest could be identified. Event-free survival (EFS) and overall survival (OS) of the whole study population were 45.3 % and 51.8 % at 3 years from the date of the graft, respectively. Forty-five patients relapsed with a median time of 15 months after graft, only four of whom had tumour cell contamination of the PBSC harvest. Tumour cell contamination of PBSC collection is rare and does not seem to be associated with a significantly poorer EFS or OS in this high-risk population.

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Localised Ewing sarcoma/PNET of bone—prognostic factors and international data comparison

Cited by 29 publications

References 23 publications

Prediction of response and prognostic factors for Ewing family of tumors in a low incidence population

Prediction of response and prognostic factors for Ewing family of tumors in a low incidence population

The novel use of small intestinal submucosal matrix for chest wall reconstruction following Ewing’s tumour resection

Incidence and prognostic value of tumour cells detected by RT–PCR in peripheral blood stem cell collections from patients with Ewing tumour

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