Local treatment of the dental caries using nanomaterials

Ahmadian, Elham; Shahi, Shahriar; Yazdani, Javad; Dizaj, Solmaz Maleki; Sharifi, Simin

doi:10.1016/j.biopha.2018.09.026

Cited by 53 publications

(38 citation statements)

References 44 publications

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“…Research has shown that fluoride has limited ability to remineralize dentin when the residual crystals of the lesion are insufficient [33]. CPP-ACP, which has been consider to promote remineralization of the carious lesions by maintaining a supersaturated state of enamel mineral, plays a key role in the biomineralization of dentin [15,34]. It has also been suggested that CPP-ACP has a multifactorial anticariogenic mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…Topographical images of the surface were performed in the tapping mode using a silicon nitride scanning probe in admosphere, in which the probe periodically touches the sample surface, producing higher quality images [15]. Each dentine disk was observed in 4 different sites and obtained three-dimensional images of the dentin surface.…”

Section: Surface Roughness Testmentioning

confidence: 99%

“…It had also been reported that several other materials could remineralize dentin, including casein phosphopeptideamorphous calcium phosphate (CPP-ACP) and fluoride compounds [1,15,16]. CPP-ACP enhances remineralization by stabilizing calcium phosphate so that high concentrations of calcium ions and phosphate ions exist in the solution.…”

Section: Introductionmentioning

confidence: 99%

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Remineralising effect of 45S5 bioactive glass on artificial caries in dentine

Mei

et al. 2020

BMC Oral Health

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Background: This study investigated the remineralisation effect of bioactive glass on artificial dentine caries. Methods: Dentine disks with artificial caries were treated with bioactive glass (group BAG), casein phosphopeptideamorphous calcium phosphate (CPP-ACP) (group CPP-ACP), sodium fluoride glycerol (group F) or deionized water (group W). All disks were subjected to pH cycling for 28 days subsequently. The topography, microhardness and remineralisation depth of the dentine carious lesion were assessed by atomic force microscopy (AFM), microhardness testing and confocal laser scanning microscope (CLSM), respectively. Results: AFM images indicated mineral depositions on the surface of the carious lesion in group BAG. The changes of Vickers hardness number (ΔVHN, mean ± SD) after pH cycling were 9.67 ± 3.60, 6.06 ± 3.83, 5.00 ± 2.19 and − 1.90 ± 2.09 (p < 0.001) in group BAG, group CPP-ACP, group F and group W, respectively. The remineralisation depth (mean ± SD) of the carious lesion in group BAG, group CPP-ACP, group F and group W were 165 ± 11 μm, 111 ± 11 μm, 75 ± 6 μm and 0 μm (p < 0.001), respectively. Conclusion: Bioactive glass possessed a promising remineralisation effect on artificial dentine caries and could be a therapeutic choice for caries management.

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Section: Discussionmentioning

confidence: 99%

Section: Surface Roughness Testmentioning

confidence: 99%

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Remineralising effect of 45S5 bioactive glass on artificial caries in dentine

Mei

et al. 2020

BMC Oral Health

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“…Plaque is a form of biofilm created by bacteria such as Streptococcus mutans , Streptococcus sobrinus [ 2 ] and Lactobacilli [ 3 ]. These cariogenic bacteria produce acid (formic-, acetic- and propionic acid) as a by-product during the metabolic process of fermentable carbohydrates, which leads to incipient caries or white spot lesions on tooth enamel [ 4 ], resulting in damaging the enamel, leading to formation of nanoscale pores [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Key Functional Motifs of Native Amelogenin Protein for Dental Enamel Remineralisation

Dissanayake

Ekambaram

et al. 2020

Molecules

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Dental caries or tooth decay is a preventable and multifactorial disease that affects billions of people globally and is a particular concern in younger populations. This decay arises from acid demineralisation of tooth enamel resulting in mineral loss from the subsurface. The remineralisation of early enamel carious lesions could prevent the cavitation of teeth. The enamel protein amelogenin constitutes 90% of the total enamel matrix protein in teeth and plays a key role in the biomineralisation of tooth enamel. The physiological importance of amelogenin has led to the investigation of the possible development of amelogenin-derived biomimetics against dental caries. We herein review the literature on amelogenin, its primary and secondary structure, comparison to related species, and its’ in vivo processing to bioactive peptide fragments. The key structural motifs of amelogenin that enable enamel remineralisation are discussed. The presence of several motifs in the amelogenin structure (such as polyproline, N- and C-terminal domains and C-terminal orientation) were shown to play a critical role in the formation of particle shape during remineralization. Understanding the function/structure relationships of amelogenin can aid in the rational design of synthetic polypeptides for biomineralisation, halting enamel loss and leading to improved therapies for tooth decay.

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“…The most common anticaries agents (liquids and varnishes) are well accepted by patients, although their retention on the dental surface is poor, leading to limited efficacy [28]. As such, nanometric materials such as nanoparticles with different compositions have been increasingly studied for use as carriers, improving not only their mechanical properties but also modified to achieve the desired size, morphology, and applicability [29,30].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial effect of anacardic acid–loaded zein nanoparticles loaded on Streptococcus mutans biofilms

et al. 2020

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Bacterial biofilms play a key role in the pathogenesis of major oral diseases. Nanoparticles open new paths for drug delivery in complex structures such as biofilms. This study evaluated the antimicrobial effect of zein nanoparticles containing anacardic acid (AA) extracted from cashew shells of Anacardium occidentale on in vitro Streptococcus mutans biofilm formation and mature biofilms. The minimum inhibitory concentration (MIC), minimum bacterial concentration (MBC), and antibiofilm assays were performed. Streptococcus mutans UA159 biofilms were formed on saliva-coated hydroxyapatite disk for 5 days. To evaluate the preventive effect on biofilm formation, before contact with the inoculum, the disks were immersed once for 2 min in (1) hydroethanolic solution; (2) blank zein nanoparticles; (3) zein nanoparticles containing AA; and (4) 0.12% chlorhexidine gluconate. To determine the effect against mature biofilms, the disks containing 5-day preformed biofilms were further treated using the same procedure. The bacterial viability and dry weight were determined for both assays and used to compare the groups using ANOVA followed by Tukey's test (p < 0.05). Both MIC and MBC for AA-loaded zein nanoparticles were 0.36 μg/mL. Groups 3 and 4 were very effective in inhibiting S. mutans biofilm formation, as no colony-forming units were detected. In contrast, for mature biofilms, no difference in bacterial viability (p = 0.28) or dry weight (p = 0.09) was found between the treatments. Therefore, the AA-based nanoformulation presented very high inhibitory and bactericidal activities against planktonic S. mutans, and the results indicate a strong antiplaque effect. However, the formulation showed no antimicrobial effect on the established biofilm.

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Local treatment of the dental caries using nanomaterials

Cited by 53 publications

References 44 publications

Remineralising effect of 45S5 bioactive glass on artificial caries in dentine

Remineralising effect of 45S5 bioactive glass on artificial caries in dentine

Identification of Key Functional Motifs of Native Amelogenin Protein for Dental Enamel Remineralisation

Antimicrobial effect of anacardic acid–loaded zein nanoparticles loaded on Streptococcus mutans biofilms

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