Local Therapy of Oral Leukoplakia with Vitamin A

Mulay, D N

doi:10.1001/archderm.1958.01560110083012

Cited by 25 publications

(2 citation statements)

References 6 publications

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“…Over 60 years have passed since the first attempts of using vitamin A and its derivatives in OL treatment were introduced [ 4 ]. Since then knowledge about these conjunctions has broadened, enabling the application of them in treatment of many other diseases.…”

Section: Discussionmentioning

confidence: 99%

Estimation of oral leukoplakia treatment records in the research of the Department of Maxillofacial and Oral Surgery, Medical University of Gdansk

Starzyńska¹,

Pawłowska²,

Renkielska³

et al. 2015

pdia

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IntroductionOral leukoplakia (OL) is the most common potentially malignant lesion of the oral cavity.AimThe purpose of the study was clinical and epidemiological analysis of patients with OL diagnosed and treated in the Department of Maxillofacial and Oral Surgery, Medical University of Gdansk, comparison of effectiveness of treatment methods, defining whether van der Waal level of OL influences treatment effectiveness, correlation between localization of OL and treatment effectiveness, and defining the optimal OL therapeutic method.Material and methodsAmong 55 911 patients diagnosed and treated in the Department in the years 1999–2009, 204 people with OL were selected (104 women, 100 men, average age: 58.1 years). Treatment and observation period of 6 months was completed by 178 (87.25%) patients. Seventy-four patients were treated with cream containing 0.05% tretinoin. Sixty-three patients underwent cryosurgery, and 41 surgery. Control visits were made in week 2, 4, 6 and 8 and 6 months after completed treatment.ResultsThree hundred and twenty lesions of OL were diagnosed. According to van der Waal classification, the largest group of patients was classified into stage I and II. The percentage of totally cured patients was 90.07%. There were no statistic differences in effectiveness between surgical and cryosurgical treatment.ConclusionsEvaluation of OL treatment methods depends on localization of the lesions and its stage of progression. The effectiveness of treatment with locally applied tretinoin is smaller in comparison to surgery and cryosurgery. It allows to reduce the number and size of OL lesions, what makes it possible to reduce the number of ablative procedures.

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Section: Discussionmentioning

confidence: 99%

Estimation of oral leukoplakia treatment records in the research of the Department of Maxillofacial and Oral Surgery, Medical University of Gdansk

Starzyńska¹,

Pawłowska²,

Renkielska³

et al. 2015

pdia

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“…Some early studies found that vitamin A has a signifcant antikeratosis efect, and it has been proven to have a good efect on vulvar leukoplakia and senile keratosis. Since oral leukoplakia is also a disorder of keratinization, in 1958, Mulay and Urbach [30] conducted a clinical trial in which they applied vitamin A tablets topically to 10 patients with typical OLK. Te results showed signifcant remission in 70% of patients, thus indicating the therapeutic potential of vitamin A in OLK patients.…”

Section: Current Status Of Retinoids In the Treatment Of Olkmentioning

confidence: 99%

Retinoid Treatment for Oral Leukoplakia: Current Evidence and Future Development

Hu,

Wang,

et al. 2024

Journal of Clinical Pharmacy and Therapeutics

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Oral leukoplakia (OLK) is one of the most common oral potentially malignant disorders (OPMDs). Preventing malignant transformation is the main purpose of OLK treatment. The treatment approaches of OLK include surgery, chemotherapy, and other therapies, such as photodynamic therapy and CO2 laser. The application of genomic variation-based chemotherapy in OLK deserves further exploration. As chemopreventive drugs, drug resistance and disease recurrence have limited their use in OLK. In this review, we concentrate on the retinoid treatment for OLK, summarizing the current status of retinoids in the treatment of OLK, the mechanism of retinoid action, and the mechanisms of resistance to retinoid therapy, and we highlight the strategies to improve retinoid efficacy in the treatment of OLK, such as the combination of retinoids and epigenetic regulators or metabolism-blocking agents, new synthetic retinoids, and new drug delivery systems of retinoids, providing new methods for the successful clinical application of retinoids in the treatment of OLK.

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