2005
DOI: 10.1161/01.hyp.0000175814.18550.c0
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Abstract: Abstract-CYP11B2 is the enzyme responsible for aldosterone synthesis mainly in the adrenal gland. In this study, we hypothesized that CYP11B2 gene, protein, and aldosterone are produced locally in kidney and regulated by low salt intake, angiotensin II type 1 (AT 1 ) receptor and insulin-deficient diabetes hyperglycemia. We used real-time RT-PCR, immunohistochemistry staining, and microdialysis techniques to monitor changes in renal CYP11B2 mRNA and protein and aldosterone production in normal, adrenalectomize… Show more

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Cited by 107 publications
(104 citation statements)
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“…15,16 Recent studies indicated that the CYP11B2 gene and protein, locally presented in kidney, were regulated by low salt intake and angiotensin II type 1 receptor. 44 These findings suggested an epistatic interaction in these 2 or more candidate genes in RAAS.…”
Section: Discussionmentioning
confidence: 96%
“…15,16 Recent studies indicated that the CYP11B2 gene and protein, locally presented in kidney, were regulated by low salt intake and angiotensin II type 1 receptor. 44 These findings suggested an epistatic interaction in these 2 or more candidate genes in RAAS.…”
Section: Discussionmentioning
confidence: 96%
“…This discrepancy might be due to limitations in the sensitivity of our aldosterone assay. Alternatively, stimulation of regional (renally synthesized) rather than systemic (adrenally synthesized) aldosterone may play an important role in renal injury (32). Interestingly, similar treatment with FAD286 (4 mg·kg Ϫ1 ·day Ϫ1 for 4 wk) decreased angiotensin II-stimulated levels of plasma aldosterone but not baseline levels in UNx rats (16).…”
Section: Discussionmentioning
confidence: 97%
“…Previous studies on adrenalectomized rats and rabbits indicated that a high-K + diet increases renal Na + and K + channel activities independent from aldosterone. 19,[21][22][23] However, because adrenalectomies in rodents are often incomplete and the existence of local aldosterone producing systems in kidney and other organs have been suggested, 25 these previous studies could not exclude that minute amounts of remaining aldosterone production could have contributed to the observed activation of Na + and K + channels in the ASDN. In AS 2/2 mice, any aldosterone production is prevented because 39 This is in line with transport and renal clearance studies on adrenalectomized laboratory animals, which suggested that aldosterone is not absolutely necessary, but plays at least a permissive role and is important to achieve maximal K + secretion.…”
Section: Discussionmentioning
confidence: 98%
“…24 Moreover, local aldosterone producing systems may exist in many organs including the kidney. 25 Hence, we used mice with targeted inactivation of the aldosterone synthase (AS) 26 to analyze in detail the cellular and molecular mechanisms involved in the regulation of K + homeostasis under conditions of complete aldosterone deficiency. Figure 1).…”
mentioning
confidence: 99%