Local lymph node activation in rats after dermal application of the sensitizers 2,4-dinitrochlorobenzene and trimellitic anhydride

Contact allergic response to dinitrochlorobenzene (DNCB) in rats: Insight from sensitization phase

“…In line with data from local lymph node assays in mice (Hope et al 1994b) and rats (Arts et al 1996), an increase in DLN cell numbers and ex vivo proliferation, the immunological correlates of hapten's contact-sensitizing potential, was noted in rats sensitized with DNCB. Higher DLN cellularity in sensitized, as compared to non-sensitized rats might be a consequence of cell migration to lymph nodes and/or cell proliferation.…”

Contact allergic response to dinitrochlorobenzene (DNCB) in rats: Insight from sensitization phase

“…In line with data from local lymph node assays in mice (Hope et al 1994b) and rats (Arts et al 1996), an increase in DLN cell numbers and ex vivo proliferation, the immunological correlates of hapten's contact-sensitizing potential, was noted in rats sensitized with DNCB. Higher DLN cellularity in sensitized, as compared to non-sensitized rats might be a consequence of cell migration to lymph nodes and/or cell proliferation.…”

Propolis suppresses atopic dermatitis through targeting the MKK4 pathway

“…To investigate the effects of propolis on regulating hypertrophy of immune organs in DNCB‐induced AD mice, we measured the size and weights of the spleen and four types of lymph nodes. AD influences immune system organs due to elevated systemic immune responses 33,34 . Induction of AD led to an increase in the size and weight of the spleen (Figure S2A,B).…”

D-galactose Intake Alleviates Atopic Dermatitis in Mice by Modulating Intestinal Microbiota

“…To investigate whether D-galactose decreases systemic immune response in mice, we measured the size and weights of the spleen and axillary lymph nodes ( 24 ). Repetitive application of DNCB increased the size and weight of spleen and axillary lymph nodes in DNCB-treated mice, which was completely restored by DXM treatment ( Figures 2A–D ).…”

Contact allergic response to dinitrochlorobenzene (DNCB) in rats: Insight from sensitization phase

“…In line with data from local lymph node assays in mice (Hope et al 1994b) and rats (Arts et al 1996), an increase in DLN cell numbers and ex vivo proliferation, the immunological correlates of hapten's contact-sensitizing potential, was noted in rats sensitized with DNCB. Higher DLN cellularity in sensitized, as compared to non-sensitized rats might be a consequence of cell migration to lymph nodes and/or cell proliferation.…”

Propolis suppresses atopic dermatitis through targeting the MKK4 pathway

“…To investigate the effects of propolis on regulating hypertrophy of immune organs in DNCB‐induced AD mice, we measured the size and weights of the spleen and four types of lymph nodes. AD influences immune system organs due to elevated systemic immune responses 33,34 . Induction of AD led to an increase in the size and weight of the spleen (Figure S2A,B).…”

D-galactose Intake Alleviates Atopic Dermatitis in Mice by Modulating Intestinal Microbiota

“…To investigate whether D-galactose decreases systemic immune response in mice, we measured the size and weights of the spleen and axillary lymph nodes ( 24 ). Repetitive application of DNCB increased the size and weight of spleen and axillary lymph nodes in DNCB-treated mice, which was completely restored by DXM treatment ( Figures 2A–D ).…”

Contact allergic response to dinitrochlorobenzene (DNCB) in rats: Insight from sensitization phase

“…In line with data from local lymph node assays in mice (Hope et al 1994b) and rats (Arts et al 1996), an increase in DLN cell numbers and ex vivo proliferation, the immunological correlates of hapten's contact-sensitizing potential, was noted in rats sensitized with DNCB. Higher DLN cellularity in sensitized, as compared to non-sensitized rats might be a consequence of cell migration to lymph nodes and/or cell proliferation.…”

Propolis suppresses atopic dermatitis through targeting the MKK4 pathway

“…To investigate the effects of propolis on regulating hypertrophy of immune organs in DNCB‐induced AD mice, we measured the size and weights of the spleen and four types of lymph nodes. AD influences immune system organs due to elevated systemic immune responses 33,34 . Induction of AD led to an increase in the size and weight of the spleen (Figure S2A,B).…”

D-galactose Intake Alleviates Atopic Dermatitis in Mice by Modulating Intestinal Microbiota

“…To investigate whether D-galactose decreases systemic immune response in mice, we measured the size and weights of the spleen and axillary lymph nodes ( 24 ). Repetitive application of DNCB increased the size and weight of spleen and axillary lymph nodes in DNCB-treated mice, which was completely restored by DXM treatment ( Figures 2A–D ).…”