Local Immunity in Mumps Meningitis

Mumps meningitis: Specific and non-specific antibody responses in the central nervous system

“…and children (Vandvik et al 1978) with mumps meningitis. Reduced serum/ CSF ratios of mumps antibody titers, consistent with an intrathecal mumps antibody production, were demonstrated in several patients in these as well as in a third study (Morishima et al 1980).…”

Analysis of serum th1/th2 cytokine levels in patients with acute mumps infection

“…The previous studies demonstrated that CD8+cytotoxic T lymphocytes (CTL) play an important role in CSF of mumps meningitis. [ 12 20 ] Taking these reports into consideration, a higher level of IFN-γ in this study may indicate that IFN-γ is mainly produced by CD8+CTL in serum of mumps infection. On the other hand, levels of IL-2, a Th1 cytokine, elevated.…”

“…Th1 cells promote cell-mediated immune response and produce gamma IFN-γ, IL-2, and tumor necrosis factor-β, whereas Th2 cells promote humoral immunity and produce IL-4, IL-5, IL-6, IL-10, and IL-13. [ 19 20 ] T-cells that produce cytokine pattern distinct from the well-defined Th-1/Th-2 sets have been described as Th-0 and Th-17, etc. [ 19 21 ]…”

Mononuclear cell subpopulations in CSF and blood of children with bacterial meningitis

“…In addition, previous studies demonstrated that CD8þ T cells play an important role in the CSF-mediated response to mumps meningitis. 19,20 Taking these reports into consideration, the role of monocytes/macrophages in BM is more important compared with that in viral meningitis, and T cells in the CSF of viral meningitis patients are activated more markedly than those of BM patients.…”