Local delivery natural products to treat periodontitis: a systematic review and meta-analysis

Sousa, Emerson Tavares de; Araújo, Jaiza Samara Macena de; Pires, Andressa Cavalcanti; Santos, Elis Janaína Lira dos

doi:10.1007/s00784-021-03774-2

Cited by 6 publications

(4 citation statements)

References 58 publications

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“…Naturally-occurring agents have been used to control the microbial challenge and host response preventing bone destruction [ 81 ]. Natural products used subgingivally are effective in PPD reduction and CAL gain as well as in eliminating the periodontal inflammation significantly compared to scaling and root planing alone or with placebo [ 82 ]. Novel herbal-based gels such as 15% natural chitosan can be used in the management of intrabony defects as an effective product for periodontal regeneration [ 83 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Effectiveness of Herbal Oral Care Products in Periodontitis Patients: A Systematic Review

Chatzopoulos

Karakostas

Kavakloglou

et al. 2022

IJERPH

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Background: The use of herbal products in oral cavity has shown an increased popularity and potential benefits due to their additional anti-inflammatory and antioxidant properties as well as the lack of side effects related to their use. Objective: To assess the clinical effectiveness of herbal dental products (mouthwash, dentifrice, gel) when compared to conventional products or placebo in periodontitis patients. Material and methods: A systematic review with 22 studies was carried out using MEDLINE/Pubmed, EMBASE and Web of Science databases in addition to hand searches. Randomized and non-randomized clinical trials that evaluated the effect of any herbal dental product and compared it with conventional products or placebo in periodontitis patients and published up to March 2022, were screened. Results: Herbal products used as adjuncts to scaling and root planing (SRP) or supragingival debridement (SPD) led to superior clinical outcomes than placebo or no adjuncts (8 studies). In conjunction with SRP, these products showed comparable outcomes with chlorhexidine (6 studies) or better (4 studies). When used as adjuncts to SPD, herbal oral care products demonstrated comparable outcomes with chlorhexidine and conventional products (4 studies). Conclusions: Within the limitations of this systematic review, herbal oral care products may play a key role in the management of periodontal disease. Further well-designed studies are needed to establish their efficacy.

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Section: Discussionmentioning

confidence: 99%

Clinical Effectiveness of Herbal Oral Care Products in Periodontitis Patients: A Systematic Review

Chatzopoulos

Karakostas

Kavakloglou

et al. 2022

IJERPH

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“…Periodontitis is a chronic, multifaceted inflammatory disease that represents a public health problem because it is predicted to increase in the future [17]. It is manifesting, as seen in Figure 1, gingival inflammation, clinical attachment loss, the radiographic-assessed resorption of alveolar bone, the development of periodontal pockets, gingival bleeding on probing, teeth mobility, and, in advanced stages, premature teeth loss and depression [32][33][34][35]. Periodontitis results from a disruption of the oral microbiome balance, as these diverse communities usually coexist in equilibrium.…”

Section: Periodontitis and Its Pathogenesismentioning

confidence: 99%

Exploring the Efficacy of Novel Therapeutic Strategies for Periodontitis: A Literature Review

Radu,

Arbănaşi

et al. 2024

Life

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Periodontitis, a prevalent oral condition, is facing difficulties in therapeutic approaches, sometimes leading to failure. This literature review was conducted to investigate the diversity of other therapeutic approaches and their potential contributions to the successful management of the disease. This research scrutinized the alterations in microbial diversity and imbalances in crucial microbial species, which contribute significantly to the pathogenesis of periodontitis. Within the limitations of this study, we highlight the importance of understanding the treatment plan’s role in periodontitis disease, opening the way for further research and innovative treatment plans to mitigate the impact of periodontitis on oral health. This will aid both healthcare professionals and patients in preventing and effectively treating periodontitis, ultimately improving oral health outcomes and overall systemic health and well-being.

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“…The most relevant flaw of SRP is the absence of a long-term effect due to an eventual bacterial recolonization after the therapy [9]. Accordingly, adjunctive treatments have been introduced in addition to SRP, e.g., the use of antibiotics, the photodynamic therapy, the administration of antioxidants, natural compounds [10], supplements (e.g., melatonin) [11], and, in recent years, probiotic therapy [12]. Particularly, this last approach is gaining attention in the scientific community because of the absence of the side effects commonly related to antibiotics intake [13].…”

Section: Introductionmentioning

confidence: 99%

Paraprobiotics in Non-Surgical Periodontal Therapy: Clinical and Microbiological Aspects in a 6-Month Follow-Up Domiciliary Protocol for Oral Hygiene

et al. 2022

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Periodontal disease represents a progressive destruction of tooth-supporting tissues. Recently, paraprobiotics are regarded as an adjunctive therapy to the non-surgical Scaling-and-Root-Planing (SRP). The aim of this study is to evaluate the efficacy of two new formulations of paraprobiotics, a toothpaste and a mouthwash, respectively, for the domiciliary hygiene. A total of 40 patients were randomly assigned to the following domiciliary treatments: Group 1 (SRP + Curasept Intensive Treatment 0.2% chlorhexidine) (control) and Group 2 (SRP + Biorepair Peribioma toothpaste + Biorepair Peribioma Mousse mouthwash) (trial). At baseline (T0) and after 3 and 6 months (T1–T2), periodontal clinical (Bleeding on Probing, Probing Pocket Depth, Clinical Attachment Loss, Bleeding Score, Sulcus Bleeding Index, Plaque Index, Approximal Plaque Index, Adherent Gingiva, Gingival Recession, and Pathological Sites) and microbiological parameters (Pathological Bacteria, Saprophytic Bacteria, Enlarged Red Complex, Red Complex, Orange Complex, and counts of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythensys, Treponema denticola, Prevotella intermedia, and Fusobacterium nucleatum). The use of the experimental products resulted in a significant reduction of most of the clinical indices assessed, which occurred at a major degree with respect to the conventional chlorhexidine considered as control. Additionally, after 6 months of use, the abovementioned products significantly decreased the percentage of pathological bacteria and the counts of those bacteria constituting the “Red Complex”, more related to the periodontal disease. Accordingly, the paraprobiotics-based products tested in this study seem to represent a valid support to SRP with a benefit on both clinical indices and on specific periodontopathogens.

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Local delivery natural products to treat periodontitis: a systematic review and meta-analysis

Cited by 6 publications

References 58 publications

Clinical Effectiveness of Herbal Oral Care Products in Periodontitis Patients: A Systematic Review

Clinical Effectiveness of Herbal Oral Care Products in Periodontitis Patients: A Systematic Review

Exploring the Efficacy of Novel Therapeutic Strategies for Periodontitis: A Literature Review

Paraprobiotics in Non-Surgical Periodontal Therapy: Clinical and Microbiological Aspects in a 6-Month Follow-Up Domiciliary Protocol for Oral Hygiene

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