Local Calcium Release in Dendritic Spines Required for Long-Term Synaptic Depression

Miyata, Mariko; Finch, Elizabeth A.; Khiroug, Leonard; Hashimoto, Kouichi; Hayasaka, Shizu; Oda, Sen-ichi; Inouye, Minoru; Takagishi, Yoshiko; Augustine, George J; Kano, Masanobu

doi:10.1016/s0896-6273(00)00099-4

Cited by 225 publications

(255 citation statements)

References 73 publications

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“…Fiala et al (1996) modelled how the metabotropic glutamate receptor (mGluR) system may create the spectrum of delays during cerebellar adaptively timed learning. Subsequent experiments confirmed a role for calcium signalling and mGluR in cerebellar adaptive timing (Finch & Augustine 1998;Takechi et al 1998;Ichise et al 2000;Miyata et al 2000). This model simulates both normal adaptively timed conditioning data and premature responding when cerebellar cortex is lesioned (Perrett et al 1993).…”

Section: Spectral Timing In Cerebellum and Hippocampus: Timed Actionmentioning

confidence: 80%

Cortical and Subcortical Predictive Dynamics and Learning during Perception, Cognition, Emotion, and Action

Grossberg¹

2011

Predictions in the Brain

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An intimate link exists between the predictive and learning processes in the brain. Perceptual / cognitive and spatial/motor processes use complementary predictive mechanisms to learn, recognize, attend and plan about objects in the world, determine their current value, and act upon them. Recent neural models clarify these mechanisms and how they interact in cortical and subcortical brain regions. The present paper reviews and synthesizes data and models of these processes, and outlines a unified theory of predictive brain processing.

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Section: Spectral Timing In Cerebellum and Hippocampus: Timed Actionmentioning

confidence: 80%

Cortical and Subcortical Predictive Dynamics and Learning during Perception, Cognition, Emotion, and Action

Grossberg¹

2011

Predictions in the Brain

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“…Purkinje cells require the synergistic action of mGluRs and a rise in IP 3 to release Ca 2ϩ from intracellular stores with voltage-sensitive Ca 2ϩ channels for the induction of LTD (39)(40)(41). In the absence of mGluR1 or of IP 3 receptors, LTD is not observed in Purkinje cells and motor coordination is abnormal (42)(43)(44). Blocking mGluRs, presumably a major source of IP 3 , does not block LTD in cartwheel cells.…”

Section: Discussionmentioning

confidence: 98%

Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus

Fujino

Oertel

2002

Proc. Natl. Acad. Sci. U.S.A.

116

133

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The dorsal cochlear nucleus integrates acoustic with multimodal sensory inputs from widespread areas of the brain. Multimodal inputs are brought to spiny dendrites of fusiform and cartwheel cells in the molecular layer by parallel fibers through synapses that are subject to long-term potentiation and long-term depression. Acoustic cues are brought to smooth dendrites of fusiform cells in the deep layer by auditory nerve fibers through synapses that do not show plasticity. Plasticity requires Ca 2؉ -induced Ca 2؉ release; its sensitivity to antagonists of N-methyl-D-aspartate and metabotropic glutamate receptors differs in fusiform and cartwheel cells.A uditory nerve fibers bring acoustic information to the cochlear nucleus and feed it into several parallel pathways that ascend through the brainstem. Pathways through the dorsal cochlear nucleus (DCN) are thought to detect spectral cues for localizing sounds monaurally (1). Those through the ventral cochlear nucleus (VCN) encode spectral and temporal characteristics that allow sounds to be localized in the horizontal plane, through binaural circuits, and recognized.The DCN resembles the cerebellum, cartwheel cells being homologues of cerebellar Purkinje cells (2). Fusiform cells project to the inferior colliculus. Granule cells in the vicinity of the cochlear nuclei are innervated by diverse regions of the brain, including the dorsal column nuclei (1), vestibular periphery (3), and auditory nuclei (4, 5). Their unmyelinated axons, parallel fibers, contact spiny dendrites of fusiform and cartwheel cells. Myelinated auditory nerve fibers contact smooth basal dendrites of fusiform cells. The DCN resembles the electrosensory lobes in fishes even more closely (6, 7).In cerebellar circuits, the gain of one of two converging systems of inputs varies as a function of activity. Long-term depression (LTD) at parallel fiber synapses in cerebellar Purkinje cells evoked by coincident excitation through parallel fiber and climbing fiber synapses plays a role in coordination and motor learning (8). Long-term potentiation (LTP) and LTD at parallel fiber synapses are evoked in electric fishes by convergent excitation by parallel fibers and sensory afferents to compensate for an animal's own signals in localizing external sources (9). We show that principal cells of the DCN combine multimodal inputs through parallel fibers whose strength is modulated by activity with invariant acoustic input through auditory nerve fibers. MethodsCoronal slices (200 m) containing the DCN were prepared from ICR mice (Harlan-Sprague-Dawley) between 18 and 20 days old with an oscillating tissue slicer (VT1000S, Leica Microsystems, Nussloch, Germany). Slices were held in a 300-l chamber that was superfused at 3-5 ml͞min with oxygenated saline at Ϸ33°C. Experiments were done in accordance with the protocols and guidelines of the Animal Care and Use Committee at the University of Wisconsin, Madison.Whole-cell patch-clamp recordings were generally made with 3-to 5-M⍀ pipettes filled with a K-gluconate-base...

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“…Further confirmation and extension of these findings came from studies showing that a perturbation of the mGluR1-activated signaling cascade at virtually every level [e.g., G-protein G␣q (Offermanns et al, 1997), phospholipase C␤ (Kano et al, 1998), and IP 3 (Matsumoto et al, 1996;Miyata et al, 2000)] results in impaired LTD and disturbed cerebellar motor control. IP 3 causes Ca 2ϩ release from intracellular stores (Mikoshiba et al, 1994;Finch and Augustine, 1998;Takechi et al, 1998), and synaptically induced dendritic Ca 2ϩ signaling has been known for a long time to be a critical step in LTD induction (Sakurai, 1990;Konnerth et al, 1992).…”

Section: Introductionmentioning

confidence: 90%

Calbindin in Cerebellar Purkinje Cells Is a Critical Determinant of the Precision of Motor Coordination

et al. 2003

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Local Calcium Release in Dendritic Spines Required for Long-Term Synaptic Depression

Cited by 225 publications

References 73 publications

Cortical and Subcortical Predictive Dynamics and Learning during Perception, Cognition, Emotion, and Action

Cortical and Subcortical Predictive Dynamics and Learning during Perception, Cognition, Emotion, and Action

Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus

Calbindin in Cerebellar Purkinje Cells Is a Critical Determinant of the Precision of Motor Coordination

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