Local Anesthetic Systemic Toxicity

Wadlund, Diana L.

doi:10.1016/j.aorn.2017.08.015

Cited by 36 publications

(31 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Early signs and symptoms of LAST include a metallic taste, tinnitus, perioral paresthesia, lightheadedness, dizziness, and confusion . Symptoms can appear within 30 seconds to several hours after the anesthesia professional injects the local anesthetic; typically, symptoms appear within minutes . For short procedures (eg, less than 30 minutes), personnel may not identify LAST until the patient is in the PACU; the onset of symptoms will vary from patient to patient.…”

Section: Local Anesthetic Systemic Toxicity (Last)mentioning

confidence: 99%

“…Early signs and symptoms of LAST include a metallic taste, tinnitus, 30 perioral paresthesia, lightheadedness, dizziness, 31 and confusion. 32 Symptoms can appear within 30 seconds to several hours after the anesthesia professional injects the local anesthetic; typically, symptoms appear within minutes.…”

Section: Signs and Symptomsmentioning

confidence: 99%

“…32 Symptoms can appear within 30 seconds to several hours after the anesthesia professional injects the local anesthetic; typically, symptoms appear within minutes. 30,31 For short procedures (eg, less than 30 minutes), personnel may not identify LAST until the patient is in the PACU; the onset of symptoms will vary from patient to patient. At the author's facility, the provider administering the medication considers the patient's size and calculates the maximum dose of local anesthetic that is safe for that patient; each medication has a different permissible maximum weight-based dose.…”

Section: Signs and Symptomsmentioning

confidence: 99%

See 2 more Smart Citations

Regional Anesthesia: An Overview

Pincus¹

2019

AORN Journal

View full text Add to dashboard Cite

Advances in anesthesia techniques and guidance imaging have made regional anesthetics effective both for pain management and as a primary anesthesia modality for patients undergoing operative and other invasive procedures. Patients can receive regional anesthesia in most areas of the body, including the upper and lower extremities and torso. It is critical that perioperative nurses are familiar with regional anesthetic options and understand them well enough to support their patients in the preoperative, intraoperative, and postoperative phases of surgical care. They also should be familiar with the signs and symptoms of local anesthetic systemic toxicity and be prepared to help treat this condition as soon as indicated. Nurses play a pivotal role in ensuring patients are properly educated about regional anesthetics and remain safe throughout all phases of perioperative care.

show abstract

Section: Local Anesthetic Systemic Toxicity (Last)mentioning

confidence: 99%

Section: Signs and Symptomsmentioning

confidence: 99%

Section: Signs and Symptomsmentioning

confidence: 99%

See 1 more Smart Citation

Regional Anesthesia: An Overview

Pincus¹

2019

AORN Journal

View full text Add to dashboard Cite

show abstract

“…U hemijskoj strukturi lokalnih anestetika postoje hemijske komponente: aromatični prsten, središnji lanac i terminalni amini (Slika 1). Aromatični prsten određuje rastvorljivost lokalnih anestetika u lipidima 3 . Na osnovu hemijske strukture lokalni anestetici mogu biti amidi (lidokain, mepivakain, bupivakain, levobupivakain, ropivakain, artikain) i estri (kokain, prokain, tetrakain, benzokain).…”

Section: Lokalni Anesteticiunclassified

“…Sistemska toksičnost lokalnih anestetika (LAST) predstavlja životno ugrožavajuću komplikaciju 5 . Lokalni anestetici ometaju funkciju svih organa u koje se prenose impulsi, blokiranjem sprovođenja impulsa kroz aksone u perifernom nervnom sistemu 3 . Povećanjem koncentracije lokalnih anestetika ispoljava se njihov efekat i na centralni nervni sistem, blokadom kortikalnih inhibitornih puteva.…”

Section: Toksičnost Lokalnih Anestetikaunclassified

Surgical wound infiltration by local anesthetic: Wound infiltration

Slavković¹,

Kostić²,

Milošević³

et al. 2019

Serb J Anest Inten Therapy

View full text Add to dashboard Cite

SažetakSa razvojem ambulantne hirurgije, povećao se broj hirurških zahvata koji se izvode u uslovima lokalne infiltrativne anestezije. Infiltrativna anestezija se koristi samostalno za obezbeđivanje anestezije kod manjih hirurških procedura ili kao infiltrativna analgezija duž većih operativnih incizija u kombinaciji sa analgeticima, kod operacija u opštoj anesteziji, u sklopu multimodalnog analgetskog pristupa. Jednostruka infiltracija rane, u formi bloka na kraju hirurškog zahvata u opštoj ili regionalnoj anesteziji obezbeđuje kvalitetnu analgeziju u vremenski ograničenom intervalu, te je u cilju produženog delovanja lokalnih anestetika uvedena tehnika kontinuirane infiltrativne analgezije. Infiltrativna lokalna anestezija u kontinuiranom modalitetu smanjuje upotrebu opioidnih i neopioidnih analgetika, produžava trajanje analgezije (uglavom do 72 h) i omogućava mobilizaciju bolesnika. Pozitivan efekat infiltrativne anestezije opisan je kod operacija preponskih kila, dojke, u kardiotorakalnoj, ortopedskoj i ginekološkoj hirurgiji. U abdominalnoj hirurgiji kompleksna inervacija trbušnog zida i intraabdominalnih organa zahteva primenu kombinovanja infiltrativne anestezije sa drugim modalitetima analgezije. Infiltrativna lokalna anestezija je bezbedna tehnika jer ne dovodi do infekcije hirurške rane i ne utiče na pojavu infekcije mesta hirurškog reza. Kako bi lokalna infiltrativna anestezija u potpunosti ispunila i opravdala očekivanja, neophodno je savladati relativno jednostavnu tehniku njene primene i svrsishodno je primenjivati. AbstractA large number of surgical interventions are performed ambulatory under local infiltrative anesthesia. Local anesthetic wound infiltration provides anesthesia for minor surgical procedures and perioperatively improves analgesia after surgery in general anesthesia as part of a multimodal analgesic approach. The effect of a single block wound infiltration at the end of a surgical procedure in general or regional anesthesia provides additional analgesia for several hours. Infiltrative local anesthesia performed in a continuous modality reduces the use of analgesics, prolongs duration of analgesia and enhances the patient's mobilization. Benefits of local infiltrative anesthesia are described in inguinal hernioplasty, breast surgery, sternotomy, orthopedic, and gynecological surgery. However, in abdominal surgery, continuous infiltrative local anesthesia is combined with other analgesic modalities respecting complex innervation of the abdominal wall and intra-abdominal organs,. Wound infiltration is a safe technique without the risk of surgical wound infection. There is a lack of data about cost-benefit ratio when wound infiltration is used. In order for local infiltrative anesthesia to fully meet the expectations it is necessary to have mastery of the relatively simple technique, and the knowledge of when it is suitable to appply.

show abstract

Opioid Use and the Perioperative Patient

Johnson¹,

Patel²

2019

AORN Journal

View full text Add to dashboard Cite

Local Anesthetic Systemic Toxicity

Cited by 36 publications

References 11 publications

Regional Anesthesia: An Overview

Regional Anesthesia: An Overview

Surgical wound infiltration by local anesthetic: Wound infiltration

Opioid Use and the Perioperative Patient

Contact Info

Product

Resources

About