Lobomycosis and squamous cell carcinoma

Nogueira, Lisiane; Rodrigues, Carlos Alberto Chirano; Santos, Mônica; Talhari, Sinésio; Talhari, Carolina

doi:10.1590/s0365-05962013000200024

Cited by 13 publications

(11 citation statements)

References 4 publications

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“…In another study reported by Nogueira et al [ 32 ], a 87-year-old man presented a 30-year history of disseminated cutaneous lesions. He also noted that a lesion on the lower right limb had ulcerated during the prior seven months.…”

Section: Discussionmentioning

confidence: 98%

DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status

Barbosa

Oliveira

Tavares

et al. 2015

J Venom Anim Toxins Incl Trop Dis

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BackgroundJorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.MethodsDNA damage was assessed in the peripheral blood by the comet assay (tail intensity).ResultsThe results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.ConclusionThese results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.

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Section: Discussionmentioning

confidence: 98%

DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status

Barbosa

Oliveira

Tavares

et al. 2015

J Venom Anim Toxins Incl Trop Dis

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“…Long-term complications of lobomycosis infection can lead to squamous cell carcinoma (Beltrame et al, 2017;Grayson & Colonje, 2020). Nogueira, 2013 reported a case of squamous cell carcinoma associated with lobomycosis based on clinical findings and histopathological features (Nogueira et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Lobomycosis post long-term corticosteroid therapy: a case report

Saputra

Sriwidyani

Paskarani

et al. 2022

RSD

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Introdução: A lobomicose é uma das infecções fúngicas mais raramente relatadas em todo o mundo. A maioria dos casos relatados de lobomicose é endêmica na América Central e do Sul, especialmente em torno da Amazônia. As áreas do corpo afetadas geralmente são as orelhas, extremidades inferiores, extremidades superiores, rosto, tórax e costas. Objetivo: apresentar a evolução da lobomicose após corticoterapia de longa duração. Metodologia: Estudo descritivo do tipo relato de caso, cujos dados foram obtidos no prontuário do paciente. Apresentação do caso: Este artigo relata uma mulher de 23 anos, que sofreu feridas que cobriam quase toda a superfície do corpo sem qualquer febre. Ao exame físico, foram encontradas múltiplas úlceras com maceração das bordas da ferida e múltiplas saliências avermelhadas nas regiões anterior e posterior do tronco. Não há aparecimento de quelóides. O paciente tinha história de pênfigo vulgar e pênfigo vegetante e estava em uso de corticoterapia por longo prazo. O exame microbiológico não revelou crescimento de fungos. O exame histopatológico do tecido com coloração de Hematoxilina-Eosina e Ácido Periódico de Schiff (PAS) confirmou o diagnóstico de lobomicose. Conclusão: Com base nos achados clínicos e laboratoriais, o paciente foi diagnosticado com Lobomicose.

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“…Cutaneous leishmaniasis is the most common condition in the differential diagnosis for lobomycosis, especially if the lobomycosis is ulcerated, which is a frequent complication. Four case-patients with lobomycosis, 1 of whom died, were reported to have squamous cell carcinomas ( 3 , 44 ). However, the acrolentiginous melanoma that resulted in the death of case-patient 2 in our report was not related to lobomycosis.…”

Section: Discussionmentioning

confidence: 99%

Lobomycosis in Soldiers, Colombia

Arenas¹,

Rodríguez-Toro²,

Ortiz-Florez³

et al. 2019

Emerg. Infect. Dis.

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Lobomycosis is a disease that is endemic to the Amazon rainforest and is caused by the still uncultured fungus Lacazia loboi. This disease occurs in loggers, farmers, miners, fishermen, and persons living near coastal rivers of this region. We report 6 soldiers in Colombia in whom lobomycosis developed after military service in the Amazon area. The patients had nodular and keloid-like lesions on the face, neck, trunk, and limbs. The duration of illness ranged from 2 years to 15 years. The initial diagnosis was leishmaniasis on the basis of clinical manifestations and direct smear results, but biopsies confirmed the final diagnosis of lobomycosis. Treatment with surgical excision, itraconazole and clofazimine was satisfactory. However, the follow-up time was short. Healthcare professionals responsible for the diagnosis and treatment of skin diseases need to be able to recognize the clinical signs of lobomycosis and differentiate them from those of cutaneous leishmaniasis.

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Lobomycosis and squamous cell carcinoma

Cited by 13 publications

References 4 publications

DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status

DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status

Lobomycosis post long-term corticosteroid therapy: a case report

Lobomycosis in Soldiers, Colombia

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