2016
DOI: 10.1016/j.jtho.2016.05.014
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Abstract: This retrospective registry study suggested that LSD is an alternative to SND for selected patients with c-stage I or II NSCLC. Future prospective studies are warranted to determine whether LSD is applicable and provides clinical benefit for the general population of patients with c-stage I or II NSCLC.

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Cited by 84 publications
(67 citation statements)
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“…Some retrospective studies have demonstrated SLND is an alternative to LND for selected clinical-stage I-II patients and has the potential to become a standard procedure in surgical treatment for NSCLC (11,33,34,36,37). Meanwhile, Izbicki (10) and Graham (38) argued that LND should be routinely operated for resectable NSCLC.…”
Section: Discussionmentioning
confidence: 99%
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“…Some retrospective studies have demonstrated SLND is an alternative to LND for selected clinical-stage I-II patients and has the potential to become a standard procedure in surgical treatment for NSCLC (11,33,34,36,37). Meanwhile, Izbicki (10) and Graham (38) argued that LND should be routinely operated for resectable NSCLC.…”
Section: Discussionmentioning
confidence: 99%
“…Meanwhile, Izbicki (10) and Graham (38) argued that LND should be routinely operated for resectable NSCLC. On one hand, whether LND would increase postoperative morbidity associated with complications is not clear (10,36) and the influence on outcome such as overall survival and diseasefree survival remains controversial (5,8,17,33,34). On the other hand, the reported benefit that SLND can shorten the entire medical period along with its validity, reliability and applicability are still not very clear.…”
Section: Discussionmentioning
confidence: 99%
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“…LSLND did not have a negative prognostic impact and instead was associated with a favorable survival. This suggested that LSLND could be an alternative to SLND for selected patients with c-stage I or II NSCLC (14). In a retrospective study with c-stage IA lung cancer from the database of the diagnosed cases of NSCLC identified as a result of CT screening in the I-ELCAP cohort, the frequency of N2 metastases increased with increasing tumor size.…”
Section: Editorialmentioning
confidence: 99%
“…However, a recent study suggests that the systematic mediastinal lymphadenectomy could be replaced by lobe-specific nodal dissection (LSD) for selected patients of clinical stage I or II NSCLC. For example, the inferior mediastinal nodes were not necessary to be dissected for upper lobe NSCLC patients because no obvious benefit was observed for the 5-year OS but side effects and risks may increase by this procedure (10). Therefore, the recommendation of minimal 16 nodal dissections may not be appropriate for these selected patients.…”
mentioning
confidence: 99%