Loading Auristatin PE onto boron nitride nanotubes and their effects on the apoptosis of Hep G2 cells

Li, Wei; Xie, Xi; Wu, Tiantian; Lin, Hong; Luo, Lijie; Yang, Huan; Li, Jianbao; Yu, Xin; Lin, Xiaoding; Chen, Yongjun

doi:10.1016/j.colsurfb.2019.05.047

Cited by 7 publications

(9 citation statements)

References 43 publications

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“…CNTs and BNNTs were extensively explored for biological purposes, including their potential application to hydrophobic drug carrier carriers [14][15][16]. Due to their available hydrophobic inner space, ability to disperse in aqueous solution in the presence or absence or dispersants, and large aspect ratio, both CNTs and BNNTs can either be endocytosed or directly penetrate cell membranes, allowing targeted delivery of hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

Purification of Boron Nitride Nanotubes Enhances Biological Application Properties

Lee

Kim

Ahn

et al. 2020

IJMS

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Commercially available boron nitride nanotubes (BNNTs) and their purified form (pBNNTs) were dispersed in aqueous solutions with various dispersants, and their cytotoxicity and drug encapsulation capacity were monitored. Our data suggest that pBNNTs showed an average increase in dispersibility of 37.3% in aqueous solution in the presence of 10 different dispersants. In addition, 100 μg of pBNNTs induced an average decrease in cytotoxicity of 27.4% compared to same amount of BNNTs in normal cell lines. The same amount of pBNNTs can encapsulate 10.4-fold more drug (camptothecin) compared to BNNTs. These data suggest that the purification of BNNTs improves several of their properties, which can be applied to biological experiments and are thus essential in the biological application of BNNTs.

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Section: Introductionmentioning

confidence: 99%

Purification of Boron Nitride Nanotubes Enhances Biological Application Properties

Lee

Kim

Ahn

et al. 2020

IJMS

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“…[ 63 ] Through morphological controls and surface modifications, BN nanomaterials could be used as an effective carrier of doxorubicin and realized much enhanced intracellular drug delivery to LNCap prostate cancer cells, [ 35 ] or load Auristatin PE to trigger the mitochondrial‐mediated apoptosis of Hep G2 cells. [ 64 ] Surface chemical modifications of BN nanomaterials could further enhance the specific targeting performances by ligand‐receptor recognitions and promote the therapeutic efficacy. [ 43 , 65 ] Recent advances suggested that hollow BN nanospheres could slowly and endurably release water‐soluble B compounds, which were found to efficiently inhibit LNCap prostate cancer cell growth.…”

Section: Resultsmentioning

confidence: 99%

Biodegradable and Peroxidase‐Mimetic Boron Oxynitride Nanozyme for Breast Cancer Therapy

et al. 2021

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Nanomaterials having enzyme‐like activities are recognized as potentially important self‐therapeutic nanomedicines. Herein, a peroxidase‐like artificial enzyme is developed based on novel biodegradable boron oxynitride (BON) nanostructures for highly efficient and multi‐mode breast cancer therapies. The BON nanozyme catalytically generates cytotoxic hydroxyl radicals, which induce apoptosis of 4T1 cancer cells and significantly reduce the cell viability by 82% in 48 h. In vivo experiment reveals a high potency of the BON nanozyme for breast tumor growth inhibitions by 97% after 14‐day treatment compared with the control, which are 10 times or 1.3 times more effective than the inert or B‐releasing boron nitride (BN) nanospheres, respectively. This work highlights the BON nanozyme and its functional integrations within the BN nanomedicine platform for high‐potency breast cancer therapies.

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“…Li et al [28] Solid-state reaction PE-loaded BNNTs 0-100 µg•mL The results indicated that the biodegradation amount of the scaffolds was slower with the incorporation of BNNTs. The SEM and fluorescence microscopy images showed that the BNNTs positively impacted cell adhesion and proliferation.…”

Section: Study Selectionmentioning

confidence: 99%

“…The most dominant cell types used in the included articles were human embryonic kidney cells (HEK293, HEK293T) [24,25,74,81,154], human neuroblastoma cells (SH-SY5Y) [30,64,68,73,76,79,82,155], mouse embryonic fibroblasts (NIH/3T3) [70], human dermal fibroblasts (HDF) [31,36,48,51,55], lung fibroblasts (MRC-5) [65,156], dental pulp fibroblasts [34,41,62], lung epithelium cells (A549) [37,55,74], macrophage cells (RAW 264.7) [49,74], human liver epithelium (HeP G2) [27,28,37], human peripheral blood (NB4) [37], glioblastoma cells (malignant U87 [30,37,156], T98 [80,156]), mammary gland adenocarcinoma cells (MCF-7) [156], N9 murine microglia cells [50], osteoblasts [54,66,75,77], osteoblast precursor cell line derived from mouse musculus calvaria (M3CT3) [47]<...…”

Section: Cell Sourcesmentioning

confidence: 99%

“…In this regard, BNNTs have been investigated as potential material to target cancer cells. For instance, Li et al [28] demonstrated the Auristatin-PEcoated BNNTs as a drug delivery system to act against the liver cancer cells. The outcomes stated that the PE-BNNTs killed tumour cells and showed promise for treating liver Similarly, Kodali et al [45] reported acute toxicity both in vitro and in vivo using commercial-grade BNNTs, which are composed of∼50-60% BNNTs and∼40-50% impurities of boron and hexagonal boron nitride.…”

Section: Boron Neutron Capture Therapy (Bnct)mentioning

confidence: 99%

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In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review

Kakarla

Kong

2022

Nanomaterials

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Boron nitride nanotubes (BNNTs) are an exciting class of nanomaterials due to their unique chemical and physical characteristics. In recent decades, BNNTs have gained huge attention in research and development for various applications, including as nano-fillers for composites, semiconductor devices, hydrogen storage, and as an emerging material in biomedical and tissue engineering applications. However, the toxicity of BNNTs is not clear, and the biocompatibility is not proven yet. In this review, the role of BNNTs in biocompatibility studies is assessed in terms of their characteristics: cell viability, proliferation, therapeutic outcomes, and genotoxicity, which are vital elements for their prospective use in biomedical applications. A systematic review was conducted utilising the databases Scopus and Web of Science (WOS) (2008–2022). Additional findings were discovered manually by snowballing the reference lists of appropriate reviews. Only English-language articles were included. Finally, the significant analysis and discussion of the chosen articles are presented.

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Loading Auristatin PE onto boron nitride nanotubes and their effects on the apoptosis of Hep G2 cells

Cited by 7 publications

References 43 publications

Purification of Boron Nitride Nanotubes Enhances Biological Application Properties

Purification of Boron Nitride Nanotubes Enhances Biological Application Properties

Biodegradable and Peroxidase‐Mimetic Boron Oxynitride Nanozyme for Breast Cancer Therapy

In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review

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